Lack of Association Between rs17568 Polymorphism in OX40 Gene and Myocardial Infarction, Southern of Iran

Abstract

Tumor necrosis factor (TNF) is one of the inflammatory cytokines which has an important role in inflammation and migration of other inflammatory cells to the atherosclerotic plaques. OX40 is a member of the TNF super family receptor protein. OX40 and OX40 ligand are co-stimulators for T-cells and can increase inflammatory response in atherosclerotic plaques. The aim of this study was to determine the association of rs17568 polymorphism in OX40 gene with premature myocardial infarction. This case control study was done on 100 patients with premature acute myocardial infarction (AMI) and a similar number of sex, age and some other cardiovascular risk factor matched healthy people. The OX40 rs17568 polymorphism was genotyped, using PCR-RFLP method. A-allele frequency of rs17568 SNP was lower non-significantly in Premature AMI, compared to healthy subjects (49% vs. 51%). The analysis of rs17568 (A/G) polymorphism showed an odds ratio of 1.127 (95% CI: 0.635-1.999; P= 0.686) for the GG genotype and 5.761 (95% CI: 1.200-27.655; P= 0.029) for the AG genotype, compared to the AA genotype. The results of this study indicate that the rs17568 SNP of OX40 gene is not associated with premature AMI in the evaluated population.

Risk factors of premature coronary artery disease in Iran: A systematic review and meta‐analysis

“…A total population of 763 individuals (aged 43.6 ± 5.77 years, mean ± SD) was included in the meta‐analysis. The definition of dyslipidaemia in various studies was as follows: Total cholesterol > 250mg/dL, LDL > 160 mg/dL or on lipid‐lowering therapy According to NCEP guidelines Total cholesterol ≥ 200 mg/dL or HDL < 40 mg/dL Total cholesterol > 200mg/dL, LDL > 130 mg/dL or triglycerides > 200 mg/dL and One study mentioned no description for dyslipidaemia …”

“…Descriptive characteristics of studies Total cholesterol ≥ 200 mg/dL or HDL < 40 mg/dL 28 • Total cholesterol > 200mg/dL, LDL > 130 mg/dL or triglycerides > 200 mg/dL 25 and • One study mentioned no description for dyslipidaemia 32. …”

Lack of association of tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms (rs3850641 and rs17568) with coronary heart disease and stroke: A systematic review and meta-analysis

“…Eight publications were excluded because there were no data for rs3850641 or rs17568 polymorphisms, were unavailable to raw data, or were about other polymorphisms. Finally, a total of 11 publications ( 20 - 30 ) were included. For TNFSF4 rs3850641 polymorphism, a total of nine publications with 11 case-control studies comprising 3,865 cases and 6,344 controls were included, whereas three publications with three case-control studies comprising 785 cases and 698 controls were included for rs17568 polymorphism.…”

“…Among these findings, TNFSF4 was newly found to be related with the risk of cardiovascular and cerebrovascular diseases ( 1 - 7 ). Several studies have showed the relationship between TNFSF4 polymorphisms and the risk of CHD and stroke, but contradictory findings were observed ( 21 - 30 ). Among all polymorphisms under investigation, rs3850641 gained more attention than others.…”