A Case of Systemic Sclerosis with Sarcoidosis

Suga, Hiraku; Asano, Yoshihide; Tamaki, Zenshiro; Yamamoto, Mizuho; Sugaya, Makoto; Shimizu, Jun; Sato, Shinichi

doi:10.2340/00015555-1155

Cited by 6 publications

(4 citation statements)

References 8 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While rare, the coexistence of sarcoidosis with SSc has been reported in the published work, and we found nine cases of cutaneous lesion of sarcoidosis described in detail (Table ). Together with our two cases (cases 1 and 3), a review of these cases revealed a predominance of females (100%), with a median age of 53 years . ACA was detected in six patients (6/11; 55%) and anti‐topoisomerase I antibody was observed in three.…”

Section: Discussionsupporting

confidence: 64%

See 1 more Smart Citation

Clinical characteristics of sarcoidosis patients with systemic sclerosis‐specific autoantibody: Possible involvement of thymus and activation‐regulated chemokine and a review of the published works

Ueda‐Hayakawa

Nguyen

Kishimoto

et al. 2019

The Journal of Dermatology

View full text Add to dashboard Cite

Sarcoidosis and systemic sclerosis (SSc) are both multisystem disorders of unknown etiology. Some cases having both sarcoidosis and SSc have been reported previously. The present study was to investigate clinical features in sarcoidosis patients who possessed SSc‐specific autoantibody. The pathophysiology of each disease, including shared pathways leading to the development of both conditions, is reviewed in addition to previous reports of patients with concomitant SSc and sarcoidosis. SSc‐specific autoantibodies including anticentromere antibody (ACA), anti‐topoisomerase I antibody, anti‐RNA polymerase III antibody and anti‐U1RNP antibody were examined in sarcoidosis patients. Complete medical histories, clinical examinations and laboratory tests were conducted for all patients. For reviewing previously published reports, all cases were retrieved through a PubMed search. ACA was most frequently observed in sarcoidosis patients. Plaques and papules were the most frequent as the cutaneous sarcoidosis lesions. Soluble interleukin‐2 receptor was elevated in most of the cases (6/8, 75%), and thymus and activation‐regulated chemokine (TARC) was elevated in all cases (6/6, 100%). Together with our two cases (cases 1 and 3), a review of previously reported cases of sarcoidosis patients concomitant with SSc showed high frequency of ACA and plaques as cutaneous lesions. We suppose that TARC may play some roles in the production of SSc‐specific autoantibodies and development of concomitance with SSc in sarcoidosis, although the mechanisms remain unknown.

show abstract

Section: Discussionsupporting

confidence: 64%

“…Together with our two cases (cases 1 and 3), a review of these cases revealed a predominance of females (100%), with a median age of 53 years. 2,11,13,15,[28][29][30][31][32][33][34] ACA was detected in six patients (6/11; 55%) and anti-topoisomerase I antibody was observed in three. Only one patient had anti-RNA polymerase III antibody.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of sarcoidosis patients with systemic sclerosis‐specific autoantibody: Possible involvement of thymus and activation‐regulated chemokine and a review of the published works

Ueda‐Hayakawa

Nguyen

Kishimoto

et al. 2019

The Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…The relationship between SSc and sarcoidosis is not fully understood. Therefore, we reviewed the English‐language published work and found 29 cases that included both diseases concurrently . The characteristics of the 30 cases, including our case, are summarized in Table .…”

Section: Discussionmentioning

confidence: 99%

Systemic sclerosis with sarcoidosis: Case report and review of the published work

Senda

Igawa

Nishioka

et al. 2014

The Journal of Dermatology

View full text Add to dashboard Cite

Sarcoidosis and systemic sclerosis (SSc) rarely coexist. Here, we report a Japanese female SSc patient who developed systemic sarcoidosis. Her SSc was a limited type negative for anti-Scl-70 antibody and positive for anticentromere antibody (ACA). Moreover, we performed a review of the English-language published work that described cases of concurrent SSc and sarcoidosis. Then, we found that most SSc and sarcoidosis concurrent patients positive for anti-Scl-70 antibody were male (77.8%). On the other hand, most patients positive for ACA were female (87.5%). These results suggest some relationships between autoantibody profiles and sex in SSc and sarcoidosis concurrence.

show abstract

“…Sakamoto et al reported coexistence of sarcoidosis with SS and PBS and suggested that there might be a common and similar cellular immunity defect in all three diseases [12]. Similarly, Suga et al reported in a female case coexistence of sarcoidosis with SS, determined by skin and muscle biopsy [13]. It is essential to support the diagnosis of sarcoidosis with biopsy, together with the presence of hilar lymphadenopathy, systemic, and/or respiratory symptoms.…”

Section: Discussionmentioning

confidence: 99%

Coexistence of Sarcoidosis and Systemic Sclerosis

Kobak

Sever

Sivrikoz

et al. 2013

Case Reports in Rheumatology

View full text Add to dashboard Cite

Sarcoidosis is a multisystem granulomatous disease characterized by hilar lymphadenopathy, involvement of internal organs, and diverse skin lesions. Systemic sclerosis is an autoimmune disease characterized by skin hardening and different internal organ fibrosis, including vascular abnormality. Immune response associated with Th-2 has been shown in the early and active stage of the disease. In this paper, we report coexistence of systemic sclerosis with sarcoidosis in a female patient presenting with granulomatous dermatitis, interstitial lung disease, and Raynaud's phenomenon complaints.

show abstract

A Case of Systemic Sclerosis with Sarcoidosis

Cited by 6 publications

References 8 publications

Clinical characteristics of sarcoidosis patients with systemic sclerosis‐specific autoantibody: Possible involvement of thymus and activation‐regulated chemokine and a review of the published works

Clinical characteristics of sarcoidosis patients with systemic sclerosis‐specific autoantibody: Possible involvement of thymus and activation‐regulated chemokine and a review of the published works

Systemic sclerosis with sarcoidosis: Case report and review of the published work

Coexistence of Sarcoidosis and Systemic Sclerosis

Contact Info

Product

Resources

About