Coexistence of Sarcoidosis and Systemic Sclerosis

Kobak, Şenol; Sever, Fidan; Sivrikoz, Oya Nermin; Karaarslan, Ahmet

doi:10.1155/2013/684216

Cited by 12 publications

(11 citation statements)

References 15 publications

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“…While rare, the coexistence of sarcoidosis with SSc has been reported in the published work, and we found nine cases of cutaneous lesion of sarcoidosis described in detail (Table ). Together with our two cases (cases 1 and 3), a review of these cases revealed a predominance of females (100%), with a median age of 53 years . ACA was detected in six patients (6/11; 55%) and anti‐topoisomerase I antibody was observed in three.…”

Section: Discussionsupporting

confidence: 64%

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Clinical characteristics of sarcoidosis patients with systemic sclerosis‐specific autoantibody: Possible involvement of thymus and activation‐regulated chemokine and a review of the published works

Ueda‐Hayakawa

Nguyen

Kishimoto

et al. 2019

The Journal of Dermatology

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Sarcoidosis and systemic sclerosis (SSc) are both multisystem disorders of unknown etiology. Some cases having both sarcoidosis and SSc have been reported previously. The present study was to investigate clinical features in sarcoidosis patients who possessed SSc‐specific autoantibody. The pathophysiology of each disease, including shared pathways leading to the development of both conditions, is reviewed in addition to previous reports of patients with concomitant SSc and sarcoidosis. SSc‐specific autoantibodies including anticentromere antibody (ACA), anti‐topoisomerase I antibody, anti‐RNA polymerase III antibody and anti‐U1RNP antibody were examined in sarcoidosis patients. Complete medical histories, clinical examinations and laboratory tests were conducted for all patients. For reviewing previously published reports, all cases were retrieved through a PubMed search. ACA was most frequently observed in sarcoidosis patients. Plaques and papules were the most frequent as the cutaneous sarcoidosis lesions. Soluble interleukin‐2 receptor was elevated in most of the cases (6/8, 75%), and thymus and activation‐regulated chemokine (TARC) was elevated in all cases (6/6, 100%). Together with our two cases (cases 1 and 3), a review of previously reported cases of sarcoidosis patients concomitant with SSc showed high frequency of ACA and plaques as cutaneous lesions. We suppose that TARC may play some roles in the production of SSc‐specific autoantibodies and development of concomitance with SSc in sarcoidosis, although the mechanisms remain unknown.

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Section: Discussionsupporting

confidence: 64%

“…Together with our two cases (cases 1 and 3), a review of these cases revealed a predominance of females (100%), with a median age of 53 years. 2,11,13,15,[28][29][30][31][32][33][34] ACA was detected in six patients (6/11; 55%) and anti-topoisomerase I antibody was observed in three. Only one patient had anti-RNA polymerase III antibody.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of sarcoidosis patients with systemic sclerosis‐specific autoantibody: Possible involvement of thymus and activation‐regulated chemokine and a review of the published works

Ueda‐Hayakawa

Nguyen

Kishimoto

et al. 2019

The Journal of Dermatology

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“…They reported that the prognoses of the diseases are worse when they are co-occurrent, but they could not generalise this because of the low number of patients in their study. In another study, a female patient presenting with granulomatous dermatitis and interstitial pulmonary disease was diagnosed as scleroderma and sarcoidosis co-occurrence after radiological and histopathological evaluation 12. Sarcoidosis and RA co-occurrence is rarely reported.…”

Section: Discussionmentioning

confidence: 99%

Co-occurrence of rheumatoid arthritis and sarcoidosis

et al. 2015

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SUMMARYRheumatoid arthritis (RA) is a chronic inflammatory disease characterised by erosive arthritis. Sarcoidosis is a chronic disease characterised by formation of non-calcified granulomas. Our case, a 35-year-old woman, presented with metacarpophalangeal, proximal interphalangeal (PİP) joints and arthritis of both ankles, of 6-month duration. She had morning stiffness lasting 1 h, restriction of range of motion and erythaema nodosum. Laboratory tests showed elevated acute phase responses and serum ACE levels, and anti-cyclic citrullinated peptide antibody positivity. There was periarticular osteoporosis on her hand and wrist on direct X-rays and hilar lymphadenopathy on her thorax CT. The pathological result of endobronchial ultrasound biopsy showed non-calcified granuloma congruent with sarcoidosis. According to clinical, laboratory and histopathological evaluation, the patient was diagnosed with RA and sarcoidosis. Corticosteroids and methotrexate were started, and on her sixth month of follow-up, her clinical and laboratory findings and lymphadenopathies on CT had regressed. The clinical follow-up continues; the patient appears to be in clinical remission. BACKGROUND

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“…Again, similar to other studies, ankle, knee and wrist were the most common joints involved. Chronic sarcoid arthritis is less common and seen in diffuse disease and in the black race, and it involves joints such as knee, ankle, wrist, and MCP and PIP joints [Torralba and Quismorio, 2003] [Kobak et al 2013;Iannuzzi et al 2007]. In our series, 11 patients had another rheumatic pathology concurrent with sarcoidosis Our study has some limitations.…”

Section: Discussionmentioning

confidence: 94%

The clinical characteristics of sarcoid arthropathy based on a prospective cohort study

Kobak

Sever

Usluer

et al. 2016

Therapeutic Advances in Musculoskeletal

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Background: Sarcoidosis is known as a Th1-mediated disease, which can mimic many primary rheumatologic diseases or sometimes co-exist with them. Clinical characteristics of sarcoid arthropathy are not well described and the studies reported in the literature so far are mostly based on data from referrals. The aim of this study was to evaluate the incidence and clinical characteristics of sarcoid arthropathy. Methods: All our patients were prospectively evaluated in our rheumatology outpatient center from 2011 to 2015. A total of 114 (32 male) patients with sarcoidosis who were admitted to our clinic were included in the study. Clinical, demographical, laboratory, radiological and histological data of these patients obtained during 4-year follow-up and treatment period were compiled and analyzed. Results: The mean patient age was 48.1 years (range, 20-82 years), and the mean disease duration was 40.5 months (range, 1-300 months). Sarcoid arthritis was observed in 71 (62.3%), and arthralgia in 106 (92.9%) patients. Out of the 71 patients with arthritis, 61 (85.9%) had involvement of ankle, 7 (9.8%) knee, 2 (2.8%) wrist, MCP and PIP joints, and 1 (1.4%) had shoulder periarthritis. Oligoarthritis (two to four joints) was the most common pattern followed by monoarthritis and polyarthritis. Arthritis and erytjhema nodosum and arthritis and female sex was found to be correlated (p = 0.03 and p = 0.001). Again, in patients with arthritis, even higher levels of CRP/ESR as well as ANA and RF positivity were observed (p = 0.03, p = 0.01, p = 0.01, and p = 0.02, respectively). A total of 11 patients had another rheumatic pathology concurrent with sarcoidosis. Conclusions: Inflammatory arthritis occurs in a majority of patients with sarcoidosis. Acute arthritis with bilateral ankle involvement is the most common pattern of sarcoid arthropathy. Sarcoidosis can mimic many primary rheumatic diseases or may coexist with them. Sarcoidosis should be considered not only as a mimicker but also as a Th1-mediated primary rheumatologic pathology.

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Coexistence of Sarcoidosis and Systemic Sclerosis

Cited by 12 publications

References 15 publications

Clinical characteristics of sarcoidosis patients with systemic sclerosis‐specific autoantibody: Possible involvement of thymus and activation‐regulated chemokine and a review of the published works

Clinical characteristics of sarcoidosis patients with systemic sclerosis‐specific autoantibody: Possible involvement of thymus and activation‐regulated chemokine and a review of the published works

Co-occurrence of rheumatoid arthritis and sarcoidosis

The clinical characteristics of sarcoid arthropathy based on a prospective cohort study

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