Systemic sclerosis with sarcoidosis: Case report and review of the published work

Abstract

Sarcoidosis and systemic sclerosis (SSc) rarely coexist. Here, we report a Japanese female SSc patient who developed systemic sarcoidosis. Her SSc was a limited type negative for anti-Scl-70 antibody and positive for anticentromere antibody (ACA). Moreover, we performed a review of the English-language published work that described cases of concurrent SSc and sarcoidosis. Then, we found that most SSc and sarcoidosis concurrent patients positive for anti-Scl-70 antibody were male (77.8%). On the other hand, most patients positive for ACA were female (87.5%). These results suggest some relationships between autoantibody profiles and sex in SSc and sarcoidosis concurrence.

Clinical characteristics of sarcoidosis patients with systemic sclerosis‐specific autoantibody: Possible involvement of thymus and activation‐regulated chemokine and a review of the published works

“…While rare, the coexistence of sarcoidosis with SSc has been reported in the published work, and we found nine cases of cutaneous lesion of sarcoidosis described in detail (Table ). Together with our two cases (cases 1 and 3), a review of these cases revealed a predominance of females (100%), with a median age of 53 years . ACA was detected in six patients (6/11; 55%) and anti‐topoisomerase I antibody was observed in three.…”

“…Subcutaneous nodule or erythema nodosum were observed in one case each. We found that three out of 11 cases showed cutaneous sarcoidosis lesion on dorsa of the hands . All of these three cases showed non‐caseating epithelioid cell granulomas in the dermis with the thickened collagen bundles.…”

“…hands. 29,33,34 All of these three cases showed non-caseating epithelioid cell granulomas in the dermis with the thickened collagen bundles. In our present case 3, we also found noncaseating epithelioid cell granulomas with the thickened collagen bundles (Fig.…”

“…Together with our two cases (cases 1 and 3), a review of these cases revealed a predominance of females (100%), with a median age of 53 years. 2,11,13,15,[28][29][30][31][32][33][34] ACA was detected in six patients (6/11; 55%) and anti-topoisomerase I antibody was observed in three. Only one patient had anti-RNA polymerase III antibody.…”

Systemic sclerosis and sarcoidosis: a rare case of chronic intestinal pseudo-obstruction

“…SSc and sarcoidosis are rare diseases with an incidence between 50-400 million cases/year, 20 million cases/year, and the coexistence of both conditions is extremely rare (1). Only 30 cases have been reported in the literature (2) and some authors question the association of both con-…”