A biomimetic nanocomposite made of a ginger-derived exosome and an inorganic framework for high-performance delivery of oral antibodies

Abstract

A biomimetic nanocomposite made of a ginger-derived exosome and an inorganic framework enables high-performance delivery of infliximab via the oral route for inflammatory bowel disease therapy.

Immune-awakening Saccharomyces-inspired nanocarrier for oral target delivery to lymph and tumors

“…For poorly soluble molecules, MSN used ensures stable amorphous dispersion due to their excellent structural properties 25 , 26 , 27 . For macromolecules, MSN can also allow high loading by multiple loading methods, including adsorption and covalent bonding, because of their huge superficial area and functional groups 20 , 28 . Thus, we here selected MSN as a core-structure for a Saccharomyces -inspired nanomaterial to load large amounts of insoluble Len (lenvatinib, a kind of tyrosine kinase inhibitor) in a stable amorphous form.…”

The application of natural product-delivering micro/nano systems in the treatment of inflammatory bowel disease

“…Printed with permission from Royal Society of Chemistry. 46 Copyright 2021. traditional pharmaceutical excipient. Recently, more and more studies have extended its application into the drug delivery system area.…”

The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis Treatment

“…As nanoparticles with bilayer phospholipid structure, PELNs can be used as a carrier for anti-inflammatory drug loading. Orally administrated infliximab-loaded GELNs show gastrointestinal stability, colontargeted delivery, high intestinal epithelium permeability, and better efficacy in colitis than the intravenously administered infliximab (103). PELNs are innocuous and non-immunogenic nanoparticles with higher uptake in human cells compared with other artificial nanoparticles used in drug delivery (15).…”