The application of natural product-delivering micro/nano systems in the treatment of inflammatory bowel disease

Zhou, Yixuan; Feng, Xiaoying; Xu, Hongbo; Guo, Jing; Yang, Conglian; Kong, Li; Zhang, Zhiping

doi:10.1039/d2tb01965e

Cited by 7 publications

(4 citation statements)

References 70 publications

(89 reference statements)

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“…The drug metabolism program was measured by taking saliva samples and recovering the CLZ content therein, and a decision was made on whether to continue the administration or not (Figure 6C). [53,54] Prior to systematic in vitro rats drug delivery experiments, target CLZ was recovered from different real sample environments, including plasma samples, and corresponding serum samples, urine samples, and saliva samples. [55] As shown in Figure 6D, the recovery for spiked CLZ in all four samples showed high accuracy, and the errors were within acceptable limits, indicating that the sensor was suitable for CLZ testing in the above four samples.…”

Section: Resultsmentioning

confidence: 99%

Domain‐Limited Sub‐Nanometer Co Nanoclusters in Defective Nitrogen Doped Carbon Structures for Non‐Invasive Drug Monitoring

Yu,

Tang,

Gao

et al. 2023

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In this work, sub‐nanometer Co clusters anchored on porous nitrogen‐doped carbon (C─N─Co NCs) are successfully prepared by high‐temperature annealing and pre‐fabricated template strategies for non‐invasive sensing of clozapine (CLZ) as an efficient substrate adsorption and electrocatalyst. The introduction of Co sub‐nanoclusters (Co NCs) provides enhanced electrochemical performance and better substrate adsorption potential compared to porous and nitrogen‐doped carbon structures. Combined with ab initio calculations, it is found that the favorable CLZ catalytic performance with C─N─Co NCs is mainly attributed to possessing a more stable CLZ adsorption structure and lower conversion barriers of CLZ to oxidized state CLZ. An electrochemical sensor for CLZ detection is conceptualized with a wide operating range and high sensitivity, with monitoring capabilities validated in a variety of body fluid environments. Based on the developed CLZ sensing system, the CLZ correlation between blood and saliva and the accuracy of the sensor are investigated by the gold standard method and the rat model of drug administration, paving the way for non‐invasive drug monitoring. This work provides new insights into the development of efficient electrocatalysts to enable drug therapy and administration monitoring in personalized healthcare systems.

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Section: Resultsmentioning

confidence: 99%

Domain‐Limited Sub‐Nanometer Co Nanoclusters in Defective Nitrogen Doped Carbon Structures for Non‐Invasive Drug Monitoring

Yu,

Tang,

Gao

et al. 2023

Small

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“…The medicine-learning algorithm eliminated the cross-interferences in reflection spectra for the quantitative and accurate monitoring of the four biomarker levels in brain artificial cerebrospinal fluid. Recently, fiber-optic probes embedded with engineering cells and hydrogels enabled the real-time detection of neurochemicals in the freely moving animals, 40 as shown in Figure 5C. The porous structure in hydrogels allowed the neurochemical molecules of dopamine, norepinephrine, and adenosine triphosphate rapidly diffused into the polymeric networks.…”

Section: Wearable and Implanted Biosensorsmentioning

confidence: 99%

“…(C) A fiber-optic probe embedded with engineering cells and hydrogels enabled for the real-time detection of neurochemicals in the freely moving animals. 40 Copyright 2023, The American Association for the Advancement of Science. (D) Bioresorbable fiber optic based on poly(lactic-co-glycolic acid) for implanted biosensor.…”

Section: Photosensitive Materials Off the Fiber Opticmentioning

confidence: 99%

“…The research interest of wearable and implanted biosensors has been extended from physical exercise activities to specialized healthcare, including breath, 35 temperature, 36 sport monitoring, 37 pH, 38 dissolved oxygen, 39 and neurochemical. 40 The critical information about our healthcare brings the important evidence for the clinical diagnosis and provides significant guidance for the therapy.…”

Section: Introductionmentioning

confidence: 99%

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Advance on fiber optic‐based biosensors for precision medicine: From diagnosis to therapy

Luo,

Li,

Kong

et al. 2023

Interdisciplinary Medicine

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Precision medicine that takes individual variability into account is a new way to minimize the individual variability for precise diagnosis and to establish the certain strategies of efficient therapy. Due to miniaturization sensing area, remoting detection, and flexible operation of light, fiber optics have been successfully used to develop in vitro, wearable, and implanted biosensors, exhibiting high potential in precision medicine from the diagnosis in vitro to therapy in vivo. When modified with the recognition element, the fiber optic‐based biosensor enables the point of care testing for the detection of disease biomarkers. Meanwhile, the fiber optics packaged in a needle/catheter also monitor the medical Internet of things for the continuous assessment of human health. Moreover, the light from the cladding or leaky mode in the fiber optics excites the strong photothermal effect for therapy. The fiber optic‐based biosensor addressed the drawbacks of plasmonic photothermal therapy that limited penetration depths and non‐selectivity therapy. When integrated with a photothermal agent, the fiber optic‐based biosensors provide in situ information for the diagnosis as well as specifically and efficiently kill the tumor cells in deep tissues. In this review, we summarized the advances of fiber optic‐based biosensors in the diagnosis in vitro and therapy in vivo. The challenges and prospection of the fiber optic‐based biosensor application in precision medicine were also explored in depth.

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Targeting programmed cell death in inflammatory bowel disease through natural products: New insights from molecular mechanisms to targeted therapies

Wang,

et al. 2024

Phytotherapy Research

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Inflammatory bowel disease (IBD) is an autoimmune disorder primarily characterized by intestinal inflammation and recurrent ulceration, leading to a compromised intestinal barrier and inflammatory infiltration. This disorder's pathogenesis is mainly attributed to extensive damage or death of intestinal epithelial cells, along with abnormal activation or impaired death regulation of immune cells and the release of various inflammatory factors, which contribute to the inflammatory environment in the intestines. Thus, maintaining intestinal homeostasis hinges on balancing the survival and functionality of various cell types. Programmed cell death (PCD) pathways, including apoptosis, pyroptosis, autophagy, ferroptosis, necroptosis, and neutrophil extracellular traps, are integral in the pathogenesis of IBD by mediating the death of intestinal epithelial and immune cells. Natural products derived from plants, fruits, and vegetables have shown potential in regulating PCD, offering preventive and therapeutic avenues for IBD. This article reviews the role of natural products in IBD treatment by focusing on targeting PCD pathways, opening new avenues for clinical IBD management.

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The application of natural product-delivering micro/nano systems in the treatment of inflammatory bowel disease

Abstract: Inflammatory bowel disease (IBD) is a kind of multiple intestinal diseases. Natural product molecules have been gradually developed into an important source of anti-inflammatory drugs for treating IBD, due to...

Cited by 7 publications

References 70 publications

Domain‐Limited Sub‐Nanometer Co Nanoclusters in Defective Nitrogen Doped Carbon Structures for Non‐Invasive Drug Monitoring

Domain‐Limited Sub‐Nanometer Co Nanoclusters in Defective Nitrogen Doped Carbon Structures for Non‐Invasive Drug Monitoring

Advance on fiber optic‐based biosensors for precision medicine: From diagnosis to therapy

Targeting programmed cell death in inflammatory bowel disease through natural products: New insights from molecular mechanisms to targeted therapies

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