2017
DOI: 10.1007/s00705-017-3468-0
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A betabaculovirus DNA polymerase cannot substitute for the DNA polymerase of the alphabaculovirus Autographa californica nucleopolyhedrovirus

Abstract: DNA polymerase (DNApol) is present in all baculoviruses and plays a crucial role in viral DNA replication. Previously we showed that the DNApol of the alphabaculovirus group II Spodoptera litura nucleopolyhedrovirus (SpltNPV) could partially substitute for the DNApol of a group I alphabaculovirus, Autographa californica multiple nucleopolyhedrovirus (AcMNPV). However, it is not known if a betabaculovirus DNApol could subsititute for the alphabaculovirus DNApol in AcMNPV. In this report, DNApol of the betabacul… Show more

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Cited by 3 publications
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“…These similarities originate from the requirement for viral replication complexes and a specialized nuclear compartment. A key component of viral replication complexes is DNA-dependent DNA polymerase, and most DNA viruses, such as baculoviruses, HBV and herpesviruses, exploit virally self-encoded DNA polymerase to proceed with the synthesis of viral DNA [57,62,63,64,65,66]. As a crucial enzyme in viral replication, DNA polymerase is also the main target for antiviral therapeutics.…”
Section: Requirements For the Localization Of Viral Self-encoded Dmentioning
confidence: 99%
“…These similarities originate from the requirement for viral replication complexes and a specialized nuclear compartment. A key component of viral replication complexes is DNA-dependent DNA polymerase, and most DNA viruses, such as baculoviruses, HBV and herpesviruses, exploit virally self-encoded DNA polymerase to proceed with the synthesis of viral DNA [57,62,63,64,65,66]. As a crucial enzyme in viral replication, DNA polymerase is also the main target for antiviral therapeutics.…”
Section: Requirements For the Localization Of Viral Self-encoded Dmentioning
confidence: 99%