2018
DOI: 10.1007/s00705-018-4115-0
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Identification of a novel bipartite nuclear localization signal in the DNA polymerase of the betabaculovirus Pieris rapae granulovirus

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Cited by 3 publications
(2 citation statements)
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“…As an essential gene for viral DNA replication, knockout of lef-11 will result in the stagnation of viral proliferation (Lin et al, 2002;Li et al, 2019). LEF-11 can self-interact to form homo-oligomers (dimers/tetramers), which is one of the necessary conditions for its function (Dong et al, 2015).…”
Section: Discussionmentioning
confidence: 99%
“…As an essential gene for viral DNA replication, knockout of lef-11 will result in the stagnation of viral proliferation (Lin et al, 2002;Li et al, 2019). LEF-11 can self-interact to form homo-oligomers (dimers/tetramers), which is one of the necessary conditions for its function (Dong et al, 2015).…”
Section: Discussionmentioning
confidence: 99%
“…NLSs have also been detected on the DNApol of the beta baculovirus PiraGV. But unlike the classical dichotomous NLSs, mutation or deletion of any of the clusters of basic amino acids results in nuclear translocation failure, indicating an evolutionary divergence between nucleopolyhedroviruses (NPV) and granuloviruses (GV) [66]. Revealing the mechanism of co evolution between hosts and baculovirus is beneficial for humans to better control and "utilize" baculovirus.…”
Section: Summary and Future Prospectsmentioning
confidence: 99%