Untitled

Cc, Yuan; Huang, Tien-Shang; Ht, Ng; RS, Liu; Mw, Hung; Lc, Tsai

doi:10.1023/a:1009646705467

Cited by 10 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…GAD-induced apoptosis may also be induced by several cytoskeleton-related proteins that were found to be downregulated, including microtubule-associated protein RP/EB family member 1, cytokeratin 19, cytokeratin 1, and calumenin. Namely, these proteins participate in cell cycle control and apoptosis, while cytokeratin 19 expression is known to be elevated in cervical carcinoma [75,80]. The authors found that the 14-3-3 family of proteins may have an important role in the cytotoxicity mechanism of GAD, since they were upregulated.…”

Section: Ganoderma Spp Triterpenesmentioning

confidence: 99%

Proteomic Research on the Antitumor Properties of Medicinal Mushrooms

Jakopović¹,

Oršolić

Jakopovich³

2021

Molecules

View full text Add to dashboard Cite

Medicinal mushrooms are increasingly being recognized as an important therapeutic modality in complementary oncology. Until now, more than 800 mushroom species have been known to possess significant pharmacological properties, of which antitumor and immunomodulatory properties have been the most researched. Besides a number of medicinal mushroom preparations being used as dietary supplements and nutraceuticals, several isolates from mushrooms have been used as official antitumor drugs in clinical settings for several decades. Various proteomic approaches allow for the identification of a large number of differentially regulated proteins serendipitously, thereby providing an important platform for a discovery of new potential therapeutic targets and approaches as well as biomarkers of malignant disease. This review is focused on the current state of proteomic research into antitumor mechanisms of some of the most researched medicinal mushroom species, including Phellinus linteus, Ganoderma lucidum, Auricularia auricula, Agrocybe aegerita, Grifola frondosa, and Lentinus edodes, as whole body extracts or various isolates, as well as of complex extract mixtures.

show abstract

Section: Ganoderma Spp Triterpenesmentioning

confidence: 99%

Proteomic Research on the Antitumor Properties of Medicinal Mushrooms

Jakopović¹,

Oršolić

Jakopovich³

2021

Molecules

View full text Add to dashboard Cite

show abstract

Activation of p53/p21/PUMA alliance and disruption of PI‐3/Akt in multimodal targeting of apoptotic signaling cascades in cervical cancer cells by a pentacyclic triterpenediol from Boswellia serrata

Bhushan

Malik

Kumar

et al. 2009

Molecular Carcinogenesis

View full text Add to dashboard Cite

Cervical carcinoma is a growing menace to women health worldwide. This study reports the apoptotic cell death in human cervical cancer HeLa and SiHa cells by a pentacyclic triterpenediol (TPD) from Boswellia serrata by a mechanism different from reported in HL-60 cells. It caused oxidative stress by early generation of nitric oxide and reactive oxygen species that robustly up regulated time-dependent expression of p53/p21/PUMA while conversely abrogating phosphatidylinositol-3-kinase (PI3K)/Akt pathways in parallel. TPD also decreased the expression of PI3K/pAkt, ERK1/2, NF-kappaB/Akt signaling cascades which coordinately contribute to cancer cell survival through these distinct pathways. The tumor suppressor p53 pathway predominantly activated by TPD further up-regulated PUMA, which concomitantly decreased the Bcl-2 level, caused mitochondrial membrane potential loss with attendant translocation of Bax and drp1 to mitochondria and release of pro-apoptotic factors such as cytochrome c and Smac/Diablo to cytosol leading to caspases-3 and -9 activation. In addition both the phospho-p53 and p21 were found to accumulate heavily in the nuclear fraction with attendant decrease in topoisomarase II and survivin levels. On the contrary, TPD did not affect the extrinsic signaling transduction pathway effectively through apical death receptors. Interestingly, N-acetyl cysteine, ascorbate and s-methylisothiourea (sMIT) rescued cells significantly from TPD induced DNA damage and caspases activation. TPD may thus find usefulness in managing and treating cervical cancer.

show abstract

Discovery of stage‐related proteins in esophageal squamous cell carcinoma using proteomic analysis

Liu

Wang

et al. 2007

Proteomics Clinical Apps

View full text Add to dashboard Cite

Esophageal squamous cell carcinoma (ESCC) is the major subtype of esophageal cancers in China, and characterized with high morbidity and mortality. So far, the diagnosis of ESCC is mainly dependent on the alterations in esophageal histology, but most cases of ESCC with low stage do not display visible histological abnormalities. Therefore, a deep understanding of the mechanism of ESCC progression and seeking stage-specific molecules might improve the diagnosis and therapy for ESCC. In this study, we used proteomics to analyze ESCC tissues with classification by TNM stage, and determined the proteomic features correlated with ESCC progression (from stages I to III). Proteins that exhibited significantly different expression patterns between ESCC and corresponding normal esophageal tissues were identified using MS. The identified proteins with differentiated expression mainly fell into three protein categories (i.e. cytoskeleton system-associated proteins, metabolism enzymes, and heat shock proteins). In addition, real-time PCR highlighted some molecules that were associated with tumor stages at the mRNA level, such as enolase 1, chromosome 1 ORF 10, elastase inhibitor, α B crystalline, stress-induced phosphoprotein 1, and squamous cell carcinoma antigen 1. Altogether, these data provided further information on ESCC progression and potential drug targets for ESCC clinical therapy.

show abstract

Untitled

Cited by 10 publications

References 25 publications

Proteomic Research on the Antitumor Properties of Medicinal Mushrooms

Proteomic Research on the Antitumor Properties of Medicinal Mushrooms

Activation of p53/p21/PUMA alliance and disruption of PI‐3/Akt in multimodal targeting of apoptotic signaling cascades in cervical cancer cells by a pentacyclic triterpenediol from Boswellia serrata

Discovery of stage‐related proteins in esophageal squamous cell carcinoma using proteomic analysis

Contact Info

Product

Resources

About