Proteomic Research on the Antitumor Properties of Medicinal Mushrooms

Abstract

Medicinal mushrooms are increasingly being recognized as an important therapeutic modality in complementary oncology. Until now, more than 800 mushroom species have been known to possess significant pharmacological properties, of which antitumor and immunomodulatory properties have been the most researched. Besides a number of medicinal mushroom preparations being used as dietary supplements and nutraceuticals, several isolates from mushrooms have been used as official antitumor drugs in clinical settings for several decades. Various proteomic approaches allow for the identification of a large number of differentially regulated proteins serendipitously, thereby providing an important platform for a discovery of new potential therapeutic targets and approaches as well as biomarkers of malignant disease. This review is focused on the current state of proteomic research into antitumor mechanisms of some of the most researched medicinal mushroom species, including Phellinus linteus, Ganoderma lucidum, Auricularia auricula, Agrocybe aegerita, Grifola frondosa, and Lentinus edodes, as whole body extracts or various isolates, as well as of complex extract mixtures.

Current Advances in the Functional Genes of Edible and Medicinal Fungi: Research Techniques, Functional Analysis, and Prospects

“…Proteomics is a pathway for the comprehensive understanding of molecular mechanisms, and this type of research brings "life" to genomics [21]. To date, more than 800 edible and medicinal fungi have been reported to possess important pharmacological properties, such as anti-tumor and immunomodulatory activities [22]. The use of proteomics technology allows the identification of a large number of differentially regulated proteins, providing an important platform for the discovery of potential therapeutic targets.…”

Potential of Mushrooms Bioactive for the Treatment of Skin Diseases and Disorders

“…Recent investigations into these efects have emphasized the importance of identifying the molecular mechanisms underlying these responses. Techniques such as proteomics and immunoblotting have been employed to pinpoint the specifc mushroom proteins that elicit immune reactions [133]. Furthermore, understanding the role of mushroom-derived compounds in modulating the immune system can provide insights into mitigating allergenic responses while preserving their health benefts [15].…”

Antioxidant and Immunomodulatory Activities of Polysaccharides from Fermented Wheat Products of Grifola frondosa: In Vitro Methods

“…Over the last three decades, G. frondosa has been regarded as a healthy food and is famous worldwide because of its rich dietary fiber [4], protein, carbohy-drates, vitamins, and minerals, as well as its low fat and calorie levels [5,6]. Polysaccharides from G. frondosa also possess various pharmacological effects, such as antitumor and immunomodulatory effects [7][8][9], antioxidation [10], and antihyperglycemic effects [2]. Additionally, they can act effectively on the skin and hematopoietic stem cells [2,11], providing significant benefits for human health.…”