7,8-Dihydroxyflavone nano-liposomes decorated by crosslinked and glycosylated lactoferrin: storage stability, antioxidant activity, in vitro release, gastrointestinal digestion and transport in Caco-2 cell monolayers

Chen, Yufeng; Xia, Guobin; Zhao, Zhenlei; Gu, Yanpei; Chen, Chun; Zhang, Ying

doi:10.1016/j.jff.2019.103742

Cited by 43 publications

(54 citation statements)

References 48 publications

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“…Nanoliposomes have been widely studied to know their interaction effects in different strains, cultures, and animal models for the development of new drugs, vaccines, improvement of photodynamic and cancer therapy, or even as a tool for the detection of several diseases. Among the current biomedical treatments, chemotherapy sensitization of glioblastoma (75 nm) (Papachristodoulou et al, 2019 ), gastrointestinal disorders (145 nm) (Chen et al, 2020 ), cutaneous (20 nm), and fungal infections (100 nm) (Saadat et al, 2016 ; Bhagat et al, 2019 ), encapsulation of calothrixin B as anticancer agent (108 nm) (Yingyuad et al, 2018 ) are included as some of the successful examples of nanoliposomes as drug delivery mechanisms. Figure 4 Illustrates drug administration and release pathways of nanoliposomes against cancer cells.…”

Section: Biomedical Applications Of Nanoliposomesmentioning

confidence: 99%

Insight Into Nanoliposomes as Smart Nanocarriers for Greening the Twenty-First Century Biomedical Settings

Aguilar-Pérez

Avilés-Castrillo

Medina

et al. 2020

Front. Bioeng. Biotechnol.

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The necessity to develop more efficient, biocompatible, patient compliance, and safer treatments in biomedical settings is receiving special attention using nanotechnology as a potential platform to design new drug delivery systems (DDS). Despite the broad range of nanocarrier systems in drug delivery, lack of biocompatibility, poor penetration, low entrapment efficiency, and toxicity are significant challenges that remain to address. Such practices are even more demanding when bioactive agents are intended to be loaded on a nanocarrier system, especially for topical treatment purposes. For the aforesaid reasons, the search for more efficient nano-vesicular systems, such as nanoliposomes, with a high biocompatibility index and controlled releases has increased considerably in the past few decades. Owing to the stratum corneum layer barrier of the skin, the in-practice conventional/conformist drug delivery methods are inefficient, and the effect of the administered therapeutic cues is limited. The current advancement at the nanoscale has transformed the drug delivery sector. Nanoliposomes, as robust nanocarriers, are becoming popular for biomedical applications because of safety, patient compliance, and quick action. Herein, we reviewed state-of-the-art nanoliposomes as a smart and sophisticated drug delivery approach. Following a brief introduction, the drug delivery mechanism of nanoliposomes is discussed with suitable examples for the treatment of numerous diseases with a brief emphasis on fungal infections. The latter half of the work is focused on the applied perspective and clinical translation of nanoliposomes. Furthermore, a detailed overview of clinical applications and future perspectives has been included in this review.

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Section: Biomedical Applications Of Nanoliposomesmentioning

confidence: 99%

Insight Into Nanoliposomes as Smart Nanocarriers for Greening the Twenty-First Century Biomedical Settings

Aguilar-Pérez

Avilés-Castrillo

Medina

et al. 2020

Front. Bioeng. Biotechnol.

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“…The digestion assays were carried out by the description of Chen et al. (2020) with some modifications. The samples (20 mL) were added to 20 mL of simulated gastric fluid (SGF, containing 2 mg/mL NaCl, 3.2 mg/mL pepsin, and pH 1.5) and incubated at 37 °C for 2 hr.…”

Section: Methodsmentioning

confidence: 99%

“…The in vitro release behavior was determined using a dialysis method based on the previous research with some modifications (Chen et al., 2020). Briefly, the free OPH and OPH‐Lip were placed in a dialysis bag with 8,000 to 14,000 Da molecular weight cut‐off and incubated at 90 rpm under 37 °C for 12 hr.…”

Section: Methodsmentioning

confidence: 99%

Encapsulation of oyster protein hydrolysates in nanoliposomes: Vesicle characteristics, storage stability, in vitro release, and gastrointestinal digestion

Jiang

Liu

et al. 2021

Journal of Food Science

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In this study, oyster protein hydrolysates (OPH) were obtained from oyster meat by hydrolysis using animal complex proteases and then encapsulated in nanoliposomes. The physicochemical properties, stability, and digestive characteristics of OPH‐loaded nanoliposomes were evaluated. The average size and zeta potential ranged from 95.64 to 102.39 nm and from −47.36 to −36.43 mV, respectively. Liposomes containing 4 mg/mL OPH had the highest encapsulation efficiency (74.53%). Fourier transform infrared spectroscopy analysis showed that effective ionic complexation and hydrogen bonding existed between phospholipid and peptides. The liposomes exhibited the highest stability when stored at 4 °C. Liposomal encapsulation may protect the antioxidant peptides in OPH during storage and simulated digestion. The nanoliposomes were not hydrolyzed and the structural integrity was maintained in gastric digestion, but exhibited lower stability in the intestinal phase. A prolonged release of OPH from nanoliposomes was also observed as compared with free OPH. Liposome containing protein hydrolysates may be used as a formula in functional foods. Practical Application This study provides some useful information on the application of oyster protein hydrolysates or peptides in functional foods. The incorporation into liposomes may protect the hydrolysates against harsh conditions during storage and digestion, and also prolong the release time.

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“…Interestingly, it showed the improved antioxidant activity, high bioavailability and better epithelial transport on Caco‐2 cell monolayers than 7,8‐DHF and 7,8‐DHF loaded liposome. Hence, cross‐linked or glycosylated LF coating liposomes are proven to be better delivery systems for 7,8‐DHF and other similar BACs (Yufeng Chen et al., 2020).…”

Section: Applications Of Liposomesmentioning

confidence: 99%

“…Liposome has benefits for several applications in food, functional food and BACs delivery systems (Table 2 and Figure 4). Chen et al (2020) 19.…”

Section: Applications Of Liposomesmentioning

confidence: 99%

Advancements in liposome technology: Preparation techniques and applications in food, functional foods, and bioactive delivery: A review

Ajeeshkumar

Aneesh

Raju

et al. 2021

Comp Rev Food Sci Food Safe

161

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Liposomes play a significant role in encapsulation of various bioactive compounds (BACs), including functional food ingredients to improve the stability of core. This technology can be used for promoting an effective application in functional food and nutraceuticals. Incorporation of traditional and emerging methods for the developments of liposome for loading BACs resulted in viable and stable liposome formulations for industrial applications. Thus, the advance technologies such as supercritical fluidic methods, microfluidization, ultrasonication with traditional methods are revisited. Liposomes loaded with plant and animal BACs have been introduced for functional food and nutraceutical applications. In general, application of liposome systems improves stability, delivery, and bioavailability of BACs in functional food systems and nutraceuticals. This review covers the current techniques and methodologies developed and practiced in liposomal preparation and application in functional foods.

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7,8-Dihydroxyflavone nano-liposomes decorated by crosslinked and glycosylated lactoferrin: storage stability, antioxidant activity, in vitro release, gastrointestinal digestion and transport in Caco-2 cell monolayers

Cited by 43 publications

References 48 publications

Insight Into Nanoliposomes as Smart Nanocarriers for Greening the Twenty-First Century Biomedical Settings

Insight Into Nanoliposomes as Smart Nanocarriers for Greening the Twenty-First Century Biomedical Settings

Encapsulation of oyster protein hydrolysates in nanoliposomes: Vesicle characteristics, storage stability, in vitro release, and gastrointestinal digestion

Advancements in liposome technology: Preparation techniques and applications in food, functional foods, and bioactive delivery: A review

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