Advancements in liposome technology: Preparation techniques and applications in food, functional foods, and bioactive delivery: A review

Ajeeshkumar, K.K.; Aneesh, Peruvazhipurath Appu; Raju, Navaneethan; Mathew, S.; Ravishankar, C.N.; Benjakul, Soottawat

doi:10.1111/1541-4337.12725

Cited by 161 publications

(84 citation statements)

References 199 publications

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“…Bilayer nanoliposomes are versatile nanostructure, biocompatible, easily functionalized for targeted drug delivery, and improve permeation and pharmacokinetics [ 9 , 10 ]. The incorporation of peptides into liposomes, associated with the choice of an alternative route of administration can offer several advantages in therapies using peptides [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Quality by Design Approach for the Development of Liposome Carrying Ghrelin for Intranasal Administration

et al. 2021

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The therapeutic use of peptides has increasingly recognized in the development of new therapies. However, the susceptible enzymatic cleavage is a barrier that needs to overcome. Nose-to-brain delivery associated with liposomes can protect peptides against biodegradation and improve the accessibility to brain targets. The aim was to develop a liposomal formulation as ghrelin carrier. The quality by design (QbD) approach was used as a strategy for method development. The initial risk assessments were carried out using a fishbone diagram. A screening design study was performed for the critical material attributes/critical process parameters (CMAs/CPPs) on critical quality attributes (CQAs). Liposomes were obtained by hydrating phospholipid films, followed by extrusion or homogenization, and coated with chitosan. The optimized liposome formulation was produced by high-pressure homogenization coated with chitosan, and the resulted were liposomes size 72.25 ± 1.46 nm, PDI of 0.300 ± 0.027, the zeta potential of 50.3 ± 1.46 mV, and encapsulation efficiency of 53.2%. Moreover, chitosan coating improved performance in ex vivo permeation and mucoadhesion analyzes when compared to the uncoated liposome. In this context, chitosan coating is essential for the performance of the formulations in the ex vivo permeation and mucoadhesion analyzes. The intranasal administration of ghrelin liposomes coated with chitosan offers an innovative opportunity to treat cachexia.

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Section: Introductionmentioning

confidence: 99%

Quality by Design Approach for the Development of Liposome Carrying Ghrelin for Intranasal Administration

et al. 2021

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“…To increase magnesium bioavailability, liposomes have been employed both for drug and nutrients delivery [ 25 ]. Liposomes, vesicles consisting of one or more phospholipid bilayers surrounding an aqueous solution core, are able to cross the cell membrane, carrying their contents inside the cells [ 26 ].…”

Section: Dietary Approach To Gitelman’s Syndromementioning

confidence: 99%

“…Liposomes, vesicles consisting of one or more phospholipid bilayers surrounding an aqueous solution core, are able to cross the cell membrane, carrying their contents inside the cells [ 26 ]. In the field of nutrient supplementation, liposomes are employed for vitamin and mineral delivery [ 25 ]. Recently, a new delivery system consisting of phospholipids covered by a sucrester matrix has been proposed both for iron and magnesium supplementation.…”

Section: Dietary Approach To Gitelman’s Syndromementioning

confidence: 99%

The Dietary Approach to the Treatment of the Rare Genetic Tubulopathies Gitelman’s and Bartter’s Syndromes

et al. 2021

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Gitelman’s (GS) and Bartter’s (BS) syndromes are rare, inherited autosomal recessive tubulopathies characterized by hypokalemia, metabolic alkalosis, renal sodium, chloride, and potassium and magnesium-wasting. While the treatment based on potassium, sodium, chloride, and magnesium supplementation in addition to other pharmacologic options are widely established, recommendations about the dietary approach to GS and BS still remain generic. In this review we focus on the dietary strategies to increase sodium, potassium, and magnesium intake in GS and BS patients. Potassium and magnesium-rich foods and supplements are considered together with those that may reduce through different mechanisms the potassium and magnesium plasma level. Magnesium supplementation is often poorly tolerated, causing abdominal pain and diarrhea in most patients. New formulations using liposome and, in particular, sucrosomial technology have been recently proposed for magnesium supplementation in order to increase magnesium supplement tolerability and intestinal absorption. The dietary approach to GS and BS may be very important in the therapeutic approach to these syndromes. Due to the relevance of the dietary approach to these syndromes, a nutritional counseling should always be recommended and the nutritionist should join nephrologists in the follow-up of GS and BS patient care.

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“…A tecnologia de encapsulamento em lipossoma vem sendo amplamente utilizada para desenvolver sistemas de liberação de compostos bioativos (CBA) que melhoram sua estabilidade frente a fatores como pH, temperatura, luz e oxigênio, além de promover melhorias na bioacessibilidade e biodisponibilidade desses compostos (AJEESHKUMAR et al, 2021). A Tabela 2 apresenta dados referentes a trabalhos que utilizaram a tecnologia de lipossomas para encapsulamento de compostos bioativos.…”

Section: Encapsulamento De Compostos Bioativos Em Lipossomasunclassified

Uso da tecnologia de lipossomas no encapsulamento de compostos bioativos - Revisão

et al. 2021

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Compostos como polifenóis, flavonóides e vitaminas são boas opções de compostos bioativos que podem ser usados para fortificar produtos alimentícios, aumentando a sua funcionalidade. Porém, a baixa estabilidade e biodisponibilidade desses bioativos dentro da microestrutura heterogênea do alimento e no trato gastrointestinal, dificulta a ação benéfica aos consumidores. Os lipossomas podem ser usados para encapsular compostos bioativos, uma vez que são capazes de encapsular moléculas hidrofílicas, hidrofóbicas ou ambas, simultaneamente. São amplamente usados como veículos de entrega para a incorporação de compostos bioativos lipofílicos em produtos alimentares, aumentando a sua estabilidade e biodisponibilidade. Além disso, pode ser usado para promover uma aplicação eficaz em alimentos funcionais e nutracêuticos. Na presente revisão, são abordadas as aplicações, preparação, classificação e encapsulamento de compostos bioativos utilizando o método de lipossomas.

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Advancements in liposome technology: Preparation techniques and applications in food, functional foods, and bioactive delivery: A review

Cited by 161 publications

References 199 publications

Quality by Design Approach for the Development of Liposome Carrying Ghrelin for Intranasal Administration

Quality by Design Approach for the Development of Liposome Carrying Ghrelin for Intranasal Administration

The Dietary Approach to the Treatment of the Rare Genetic Tubulopathies Gitelman’s and Bartter’s Syndromes

Uso da tecnologia de lipossomas no encapsulamento de compostos bioativos - Revisão

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