3β-Hydroxy-lanosta-8,24-dien-21-al, a New Triterpene from<i>Inontus obliquus</i>

Kahlos, K.; Hiltunen, R.; Schantz, Max von

doi:10.1055/s-2007-969674

Cited by 42 publications

(29 citation statements)

References 2 publications

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“…Inotodiol has an OH group at position 22 (C-22) of lanosterol [9]. The chemical structure of the compound in subfraction 3 was determined by comparing the MS, 1 H-NMR, and 13 C-NMR spectra (data not shown) to published library spectra and spectra in the literature [7,9,15,16]. These analyses revealed that subfraction 3 is lanosterol.…”

Section: Resultsmentioning

confidence: 99%

“…3β-Hydroxy-lanosta-8,24-dien-21-al has been identified from I. obliquus [7], and a high-molecular-weight, water-soluble, lignin-like substance from edible mushrooms of I. obliquus has been reported to inhibit the protease of type-1 human immunodeficiency virus [8]. Inotodiol isolated from the sclerotia of I. obliquus has been reported to have an inhibitory effect in a two-stage carcinogenesis test on mouse skin using 7,12-dimethyl-benz[α]anthracene [9].…”

Section: Introductionmentioning

confidence: 99%

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Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells

Chung

Jeong

et al. 2010

Nutr Res Pract

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The Chaga mushroom (Inonotus obliquus) has been used in folk medicine to treat cancers. However, limited information exists on the underlying anticancer effects of the major component of I. obliquus in vivo. We hypothesize that the pure compounds (3β-hydroxy-lanosta-8,24-dien-21-al, inotodiol and lanosterol, respectively) separated from I. obliquus would inhibit tumor growth in Balbc/c mice bearing Sarcoma-180 cells (S-180) in vivo and growth of human carcinoma cells in vitro. To test this hypothesis, the growth inhibition of each subfraction isolated from I. obliquus on human carcinoma cell lines (lung carcinoma A-549 cells, stomach adenocarcinoma AGS cells, breast adenocarcinoma MCF-7 cells, and cervical adenocarcinoma HeLa cells) was tested in vitro. Then, after S-180 implantation, the mice were fed a normal chow supplemented with 0, 0.1 or 0.2 mg of subfraction 1, 2 or 3 per mouse per day. All of the subfractions isolated from I. obliquus showed significant cytotoxic activity against the selected cancer cell lines in vitro. Subfraction 1 was more active than subfraction 2 and subfraction 3 against the A549, AGS and MCF-7 cancer cell lines in vitro. In in vivo results, subfraction 1 isolated from I. obliquus at concentrations of 0.1 and 0.2 mg/mouse per day significantly decreased tumor volume by 23.96% and 33.71%, respectively, as compared with the control. Subfractions 2 and 3 also significantly inhibited tumor growth in mice bearing S-180 as compared with the control mouse tumor. Subfraction 1 isolated from I. obliquus showed greater inhibition of tumor growth than subfractions 2 and 3, which agrees well with the in vitro results. The results suggest that I. obliquus and its compounds in these subfractions isolated from I. obliquus could be used as natural anticancer ingredients in the food and/or pharmaceutical industry.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells

Chung

Jeong

et al. 2010

Nutr Res Pract

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“…Partial Based on the spectral data and the literature on trametenolic acid, the isolated compound was identified as trametenolic acid [2]. …”

Section: Resultsmentioning

confidence: 99%

“…The antitumor activity of extracts and preparations of Chaga against Sarcoma 180 and Carcinoma 755 is due mainly to the presence of lanostane-type tetracyclic triterpenes such as lanosterol, inotodiol, and trametenolic acid [2,3]. According to the literature [3], inotodiol is the dominant tetracyclic triterpene of Chaga [3].…”

mentioning

confidence: 99%

Tetracyclic triterpenes from Inonotus Obliquus (Pers.) Pil. (Chaga) growing in Russia

Zhukovich¹,

Semenova²,

Sharikova³

et al. 2010

Pharm Chem J

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“…Data in the literature available to us indicate that the biological activity of chaga extracts is associated with triterpenes: inonotic acid, obliquic acid, inotodiol, and lanosterol. Inotodiol and lanosterol have antiblastic (antitumor) activity [1,8,9].…”

mentioning

confidence: 99%

Standardization of chaga tincture and befungin

et al. 2010

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Methods for standardizing the formulations Chaga Tincture and Befungin were developed, consisting of extraction of the non-phenol fraction predominantly containing tetracyclic triterpenes, including lanosterol and ergosterol, followed by spectrophotometry of colored complexes with vanillin in acidic conditions. The contents of tetracyclic triterpenes expressed as lanosterol ranged from 0.01% to 0.035% in Chaga Tincture and from 0.01% to 0.02% in Befungin.

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3β-Hydroxy-lanosta-8,24-dien-21-al, a New Triterpene fromInontus obliquus

Cited by 42 publications

References 2 publications

Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells

Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells

Tetracyclic triterpenes from Inonotus Obliquus (Pers.) Pil. (Chaga) growing in Russia

Standardization of chaga tincture and befungin

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