Risk Factors and Prognosis in Patients with COVID-19 and Liver Injury: A Retrospective Analysis

Shen, Jiawei; Zhuang, Ze-Hao; Zhang, Qiaoxian; Huang, Jiaofeng; Chen, Gongping; Fang, Yingying; Cheng, Aiguo

doi:10.2147/jmdh.s293378

Cited by 12 publications

(12 citation statements)

References 25 publications

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“…In agreement with our findings, Pazoki et al showed that high serum levels of ALP and AST was a risk factor of in-hospital mortality and disease severity in diabetic patients with confirmed or clinically suspected COVID-19 [ 27 ]. Shen et al reported a similar findings [ 32 ]. However, liver damage and increased levels of liver enzymes in serum including AST and ALP is also reported in the diabetic patients in Islam et al study [ 33 ].…”

Section: Discussionsupporting

confidence: 67%

Predictors of COVID-19 related death in diabetes patients: A case-control study in Iran

Borzouei

Sadeghifar

Omidi

et al. 2021

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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Background Identifying the predictors of COVID-19 related death in diabetes patients can assist physicians for detecting risk factors related to the worse outcome in these patients. In this study we investigated the predictors of the death in patients with diabetes compared with non-diabetic COVID-19 patients. Methods In the present case-control study, the case group were diabetic patients with COVID-19 and the control group included Non-diabetic COVID-19 patients. The data source regarding the demographic characteristics, clinical symptoms, laboratory, and radiological findings on admission as well as the complications, treatment, and outcomes during hospitalization were gathered from their medical record through two trained nurses. Adjusted and unadjusted odds ratios (OR) estimate were calculated using the simple and multiple logistic regression through backward model. Results The mean (SD) age of the case group was higher than that of the control group; [65.24 (12.40) years vs. 59.35 (17.34) years, respectively (P < 0.001)]. Results of the adjusted logistic regression model showed that, advanced age (+60 year) (OR = 5.13, P = 0.006), addiction (OR = 5.26, P = 0.033), high level of Blood urea nitrogen (OR = 5.85, P < 0.001), and high level of Alkaline Phosphatase (OR = 3.38, P = 0.012) in diabetic patients were significantly associated with increase the odds of death in COVID-19 patients. Conclusion We found that in COVID-19 patients with diabetes; advanced age, addiction, high level of BUN and Alp and in non-diabetic COVID-19 patients advanced age, dyspnea, high level of BUN and SGOT were associated with increase risk of death in these patients.

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Section: Discussionsupporting

confidence: 67%

Predictors of COVID-19 related death in diabetes patients: A case-control study in Iran

Borzouei

Sadeghifar

Omidi

et al. 2021

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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“…All published literature which analyzed liver biochemical parameters in COVID-19 patients was examined through databases and shown in Table 1 [ 5 , 6 , 11 , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] ]. Based on previous studies, liver biochemical parameters abnormalities were defined as the elevation of the following liver enzymes in serum: ALT > 40 U / L, AST > 40 U / L, and total bilirubin> 1.20 mg/d l. As in a previous study, we defined ALT and/or AST over three times upper limits of normal (ULN), and/or total bilirubin over two times ULN as liver injury [7] .…”

Section: Methodsmentioning

confidence: 99%

Liver function as a predictor of mortality in COVID-19: A retrospective study

Salık

Uzundere

Bıçak

et al. 2021

Annals of Hepatology

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Introduction and Objectives In many studies, varying degrees of liver damage have been reported in more than half of the COVID-19 patients. The aim of this study is to determine the effect of liver biochemical parameters abnormality on mortality in critical COVID-19 patients who have been followed in the ICU since the beginning of the pandemic process. Materials and Methods In this study 533 critical patients who admitted to the ICU due to COVID-19 were included. The patients were divided into three groups according to their ALT, AST, and total bilirubin levels at their admission to the ICU. Group 1 was formed of patients with normal liver biochemical parameters values; Group 2 was formed of patients with liver biochemical parameters abnormality; Group 3 was formed of patients with liver injury. Results 353 (66.2%) of all patients died. Neutrophil, aPTT, CRP, LDH, CK, ALT, AST, bilirubin, procalcitonin and ferritin values in Group 2 and Group 3 were found to be statistically significantly higher than Group 1. It was detected that the days of stay in ICU of the patients in Group 1 was statistically significantly longer than others group. It was found that the patients in Groups 2 and 3 had higher total, 7-day, and 28-day mortality rates than expected. Conclusions The study showed that liver disfunction was associated with higher mortality and shorter ICU occupation time.

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“…Apparently, male sex, older age, and higher body mass index are also associated with liver damage from COVID-19[ 6 , 17 , 58 , 59 ]. Besides, coexisting diseases such as hypertension, diabetes, cardiovascular disease, malignancy, and some liver diseases may all be risk factors for liver damage[ 60 , 61 ]. Currently, the susceptibility of children and pregnant women to liver injury is not fully understood.…”

Section: Risk Factors For Liver Injurymentioning

confidence: 99%

Liver injury in COVID-19: Clinical features, potential mechanisms, risk factors and clinical treatments

Zhao¹,

Li²,

Li³

et al. 2023

World J Gastroenterol

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The coronavirus disease 2019 (COVID-19) pandemic has been a serious threat to global health for nearly 3 years. In addition to pulmonary complications, liver injury is not uncommon in patients with novel COVID-19. Although the prevalence of liver injury varies widely among COVID-19 patients, its incidence is significantly increased in severe cases. Hence, there is an urgent need to understand liver injury caused by COVID-19. Clinical features of liver injury include detectable liver function abnormalities and liver imaging changes. Liver function tests, computed tomography scans, and ultrasound can help evaluate liver injury. Risk factors for liver injury in patients with COVID-19 include male sex, preexisting liver disease including liver transplantation and chronic liver disease, diabetes, obesity, and hypertension. To date, the mechanism of COVID-19-related liver injury is not fully understood. Its pathophysiological basis can generally be explained by systemic inflammatory response, hypoxic damage, ischemia-reperfusion injury, and drug side effects. In this review, we systematically summarize the existing literature on liver injury caused by COVID-19, including clinical features, underlying mechanisms, and potential risk factors. Finally, we discuss clinical management and provide recommendations for the care of patients with liver injury.

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Risk Factors and Prognosis in Patients with COVID-19 and Liver Injury: A Retrospective Analysis

Cited by 12 publications

References 25 publications

Predictors of COVID-19 related death in diabetes patients: A case-control study in Iran

Predictors of COVID-19 related death in diabetes patients: A case-control study in Iran

Liver function as a predictor of mortality in COVID-19: A retrospective study

Liver injury in COVID-19: Clinical features, potential mechanisms, risk factors and clinical treatments

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