Predictors of COVID-19 related death in diabetes patients: A case-control study in Iran

Borzouei, Shiva; Sadeghifar, Majid; Omidi, Tahereh; Bashirian, Saeed; Bahreini, Fatemeh; Heidarimoghadam, Rezvan; Khazaei, Salman

doi:10.1016/j.dsx.2021.05.022

Cited by 6 publications

(3 citation statements)

References 30 publications

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“…After deleting duplicates, we identified 2463 studies from four databases and then screened articles by title and full text according to the study's objectives. Finally, 69 studies were included in the meta-analysis (Figure 1), of which 62 studies had assessed risk factors for death from COVID 28–89 ); 13 studies determined risk factors for severity (( 41,50,53–55,65,…”

Section: Resultsmentioning

confidence: 99%

Risk Factors Associated with Severity and Death from COVID-19 in Iran: A Systematic Review and Meta-Analysis Study

Mehri

Ghorbani

Farhadi-Babadi

et al. 2023

J Intensive Care Med

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Objectives: This study aims to investigate the risk factors associated with severity and death from COVID-19 through a systematic review and meta-analysis of the published documents in Iran. Methods: A systematic search was performed based on all articles indexed in Scopus, Embase, Web of Science (WOS), PubMed, and Google Scholar in English and Scientific Information Database (SID) and Iranian Research Institute for Information Science and Technology (IRA)NDOC indexes in Persian. To assess quality, we used the Newcastle Ottawa Scale. Publication bias was assessed using Egger's tests. Forest plots were used for a graphical description of the results. We used HRs, and ORs reported for the association between risk factors and COVID-19 severity and death. Results: Sixty-nine studies were included in the meta-analysis, of which 62 and 13 had assessed risk factors for death and severity, respectively. The results showed a significant association between death from COVID-19 and age, male gender, diabetes, hypertension, cardiovascular disease (CVD), cerebrovascular disease, chronic kidney disease (CKD), Headache, and Dyspnea. We observed a significant association between increased white blood cell (WBC), decreased Lymphocyte, increased blood urea nitrogen (BUN), increased creatinine, vitamin D deficiency, and death from COVID-19. There was only a significant relationship between CVD and disease severity. Conclusion: It is recommended that the predictive risk factors of COVID-19 severity and death mentioned in this study to be used for therapeutic and health interventions, to update clinical guidelines and determine patients’ prognoses.

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Section: Resultsmentioning

confidence: 99%

Risk Factors Associated with Severity and Death from COVID-19 in Iran: A Systematic Review and Meta-Analysis Study

Mehri

Ghorbani

Farhadi-Babadi

et al. 2023

J Intensive Care Med

View full text Add to dashboard Cite

show abstract

“…For example, in a French study ( Al-Salameh et al, 2021 ), the mortality was similar for diabetic and non-diabetic patients (21.5 vs 17.4%), yet ICU admission rates still pointed to the worse COVID-19 outcome, with diabetic patients being admitted to ICU 1.5-fold more often (34.8 vs 23.0%). Several other groups reported only a small, 1.2–1.3-fold increase in mortality of diabetic people suffering from COVID-19 ( Nikpouraghdam et al, 2020 ; Borzouei et al, 2021 ; Ciardullo et al, 2021 ; Sutter et al, 2021 ; AbdelGhaffar et al, 2022 ; Adderley et al, 2022 ). Moreover, there are reports showing almost no effect or the opposite effect of diabetes on the COVID-19 course ( Argenzian et al, 2020 ; Charlotte et al, 2020 ; Huang C. et al, 2020 ; Sutter et al, 2021 ; Barrett et al, 2022 ).…”

Section: Can Diabetes Increase the Severity Of Covid-19?mentioning

confidence: 98%

Diabetes and SARS-CoV-2–Is There a Mutual Connection?

Jedrzejak

Urbaniak

Waśko

et al. 2022

Front. Cell Dev. Biol.

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SARS-CoV-2, a newly emerged virus described for the first time in late 2019, affects multiple organs in humans, including the pancreas. Here, we present the bilateral link between the pathophysiology of diabetes and COVID-19, with diabetes being COVID-19 comorbidity, and a complication of SARS-CoV-2 infection. Analysis of clinical data indicates that patients with chronic conditions like diabetes are at increased risk of severe COVID-19, hospitalization, ICU admission, and death compared to the healthy subjects. Further, we show that SARS-CoV-2 infection might be also associated with the development of new-onset diabetes and diabetic ketoacidosis. We then discuss the options for studying SARS-CoV-2 infection in pancreatic settings, including the use of human pluripotent stem cell-derived pancreatic organoids. Further, we review the presence of SARS-CoV-2 receptors in different pancreatic cell types and the infection efficiency based on pancreatic sections from COVID-19 patients and primary human islet in vitro studies. Finally, we discuss the impact of SARS-CoV-2 infection on human pancreatic cell homeostasis, focusing on β-cells.

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“…Interestingly, unlike what has been reported in KSA, a study conducted by Akbariqomi et al, found that compared to COVID-19 patients lacking DM and any other comorbidity, those that are infected and have DM only, still experience more complications and deaths ( Akbariqomi et al, 2020 ). In Iran, it was found that advanced age, addiction, high levels of blood urea nitrogen, and alkaline phosphatase are associated significantly with increased odds of death in DM COVID-19 patients ( Borzouei et al, 2021 ).…”

Section: High-risk Populationmentioning

confidence: 99%

Prognosis of COVID-19 in the middle eastern population, knowns and unknowns

Dandachi

Aljabr

2022

Front. Microbiol.

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Since its emergence in China in 2019, the SARS-CoV-2 virus has affected all countries worldwide. The virus is easily transmitted from one person to another via infected aerosols or contaminated surfaces. Unlike its counterparts, the prognosis of COVID-19 ranges from asymptomatic to critical disease or death. Several factors play a role in determining the severity of the disease in infected patients. Among others, is the pre-existence of an underlying medical condition such as diabetes, cancer, and others. Furthermore, although children are less prone to the severe form of the COVID-19 disease, they require attention due to the report of many atypical presentations of the infection, post-asymptomatic exposure. In the Middle East, little is known about the prognosis of the SARS-CoV-2 infection in high-risk categories, notably patients with diabetes, cancer, and pregnant women. The aim of this review is to summarize the current knowledge about this group of population in the middle eastern region as well as to highlight the gap in the literature. We have found that the majority of the papers were from the Gulf countries. Although, few studies were conducted; high-risk patients appear to have an increased risk of morbidity and mortality from COVID-19 compared to their counterparts. Higher levels of inflammatory markers, C-reactive protein, erythrocyte sedimentation rate, D-dimer, and ferritin levels were also observed. Children are often asymptomatic or present with atypical presentations. More studies should be conducted to determine the clinical biomarkers of COVID-19 in high-risk categories to help in patient risk stratification and management in the middle eastern population.

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Predictors of COVID-19 related death in diabetes patients: A case-control study in Iran

Cited by 6 publications

References 30 publications

Risk Factors Associated with Severity and Death from COVID-19 in Iran: A Systematic Review and Meta-Analysis Study

Risk Factors Associated with Severity and Death from COVID-19 in Iran: A Systematic Review and Meta-Analysis Study

Diabetes and SARS-CoV-2–Is There a Mutual Connection?

Prognosis of COVID-19 in the middle eastern population, knowns and unknowns

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