Liver function as a predictor of mortality in COVID-19: A retrospective study

Abstract

Introduction and Objectives In many studies, varying degrees of liver damage have been reported in more than half of the COVID-19 patients. The aim of this study is to determine the effect of liver biochemical parameters abnormality on mortality in critical COVID-19 patients who have been followed in the ICU since the beginning of the pandemic process. Materials and Methods In this study 533 critical patients who admitted to the ICU due to COVID-19 were included. The patients were divided into three groups according to their ALT, AST, and total bilirubin levels at their admission to the ICU. Group 1 was formed of patients with normal liver biochemical parameters values; Group 2 was formed of patients with liver biochemical parameters abnormality; Group 3 was formed of patients with liver injury. Results 353 (66.2%) of all patients died. Neutrophil, aPTT, CRP, LDH, CK, ALT, AST, bilirubin, procalcitonin and ferritin values in Group 2 and Group 3 were found to be statistically significantly higher than Group 1. It was detected that the days of stay in ICU of the patients in Group 1 was statistically significantly longer than others group. It was found that the patients in Groups 2 and 3 had higher total, 7-day, and 28-day mortality rates than expected. Conclusions The study showed that liver disfunction was associated with higher mortality and shorter ICU occupation time.

Preadmission usage of metformin and mortality in COVID-19 patients including the post-discharge period

“…In our study, higher ALT levels were associated with mortality. Other studies have also found that ALT can predict increased mortality [30,31]. Despite the higher ALT levels in the metformin group, a lower mortality rate may support the protective effect of metformin in our study.…”

“…After PSM, 120 MF( +) and 120 MF( −) patients were matched. ALT values (median(IQR)) of the MF ( +) group were higher than those of the MF (-) group (25(16-42) vs 19 (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), p = 0.003). ICU admission rates, in-hospital mortality rates, and postdischarge mortality rates were higher in the MF( −) group, though not significant.…”

Acute hepatitis with portal and mesenteric vein thrombosis revealing SARS-CoV-2 infection: Case report and literature review

“…In addition, as reported by Salik et al [ 19 ], the COVID-19 patients with liver dysfunction present elevated LDH, CK, ferritin, CRP, and procalcitonin levels compared to patients without liver damage. These elevated parameters levels have been associated with poor prognosis and a high mortality rate.…”

Effect of Nonalcoholic Fatty Liver Disease (NAFLD) on COVID-19: A Single-Center Study of 3983 Patients With Review of Literature

“…Elevated liver enzymes have been documented in 15-58% of patients with COVID-19 infection [ 24 ]. Some of the studies including patients without NAFLD have positively correlated elevated transaminases with the severity of COVID-19 illness [ 25 , 26 ]. However, similar to ours, the study by Wang et al (included patients with NAFLD) and Madan et al didn’t find a significant correlation between elevated transaminases and severe events or mortality [ 10 , 19 ].…”