Early MRI Blood Volume Changes in Constrictor Muscles Correlate With Postradiation Dysphagia

Gharzai, L.A.; Li, Pin; Wilkie, Joel R.; Hawkins, Peter G.; Aryal, Madhava; Lee, Choonik; Rosen, Benjamin; Lyden, Teresa; Blakely, Anna; Chapman, Christina H.; Thamarus, Jennifer; Schonewolf, Caitlin; Shah, Jennifer; Eisbruch, Avraham; Schipper, Matthew J.; Cao, Yue

doi:10.1016/j.ijrobp.2020.12.018

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…Recently, advanced functional MRI imaging has been applied to measure tissue changes during the course of radiotherapy treatment, with the intent to understand an individuals’ risk of tissue toxicity, and improve the therapeutic ratio of radiation. Mierzwa et al [13 ▪ ] reported novel findings from applying dynamic contrast-enhanced (DCE) MRI to measure blood volumes changes at baseline and mid-radiotherapy treatment, and explore its association with swallowing-related endpoints posttreatment in patients with oropharyngeal cancer. That study revealed a significant increase in blood volumes to the pharyngeal constrictor muscles, suggestive of early inflammation and oedema, and associations between increased PCM blood volume and feeding-tube dependence and aspiration posttreatment.…”

Section: Imaging In Dysphagiamentioning

confidence: 99%

Advances in and applications of imaging and radiomics in head and neck cancer survivorship

Wishart

Ward

Galloway

2023

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of Review Radiological imaging is an essential component of head/neck cancer (HNC) care. Advances in imaging modalities (including CT, PET, MRI and ultrasound) and analysis have enhanced our understanding of tumour characteristics and prognosis. However, the application of these methods to evaluate treatment-related toxicities and functional burden is still emerging. This review showcases recent literature applying advanced imaging and radiomics to the assessment and management of sequelae following chemoradiotherapy for HNC. Recent findings Whilst primarily early-stage/exploratory studies, recent investigations have showcased the feasibility of using radiological imaging, particularly advanced/functional MRI (including diffusion-weighted and dynamic contrast-enhanced MRI), to quantify treatment-induced tissue change in the head/neck musculature, and the clinical manifestation of lymphoedema/fibrosis and dysphagia. Advanced feature analysis and radiomic studies have also begun to give specific focus to the prediction of functional endpoints, including dysphagia, trismus and fibrosis. Summary There is demonstrated potential in the use of novel imaging techniques, to help better understand pathophysiology, and improve assessment and treatment of functional deficits following HNC treatment. As larger studies emerge, technologies continue to progress, and pathways to clinical translation are honed, the application of these methods offers an exciting opportunity to transform clinical practices and improve outcomes for HNC survivors.

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Section: Imaging In Dysphagiamentioning

confidence: 99%

Advances in and applications of imaging and radiomics in head and neck cancer survivorship

Wishart

Ward

Galloway

2023

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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“…Initial efforts toward consensus guidelines for qMRI on MRgRT systems have recently begun. 22 However, the current focus of qMRI in RT is on the target volume, where QIBs that monitor normal tissue toxicity 121 could be further explored. To further develop guidelines for RT QIBs, there are opportunities to learn from and work with the diagnostic qMRI community, building on pre‐existing work.…”

Section: Quantitative Mrimentioning

confidence: 99%

The future of MRI in radiation therapy: Challenges and opportunities for the MR community

Goodburn

Philippens

Lefebvre

et al. 2022

Magnetic Resonance in Med

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Radiation therapy is a major component of cancer treatment pathways worldwide. The main aim of this treatment is to achieve tumor control through the delivery of ionizing radiation while preserving healthy tissues for minimal radiation toxicity. Because radiation therapy relies on accurate localization of the target and surrounding tissues, imaging plays a crucial role throughout the treatment chain. In the treatment planning phase, radiological images are essential for defining target volumes and organs-at-risk, as well as providing elemental composition (e.g., electron density) information for radiation dose calculations. At treatment, onboard imaging informs patient setup and could be used to guide radiation dose placement for sites affected by motion. Imaging is also an important tool for treatment response assessment and treatment plan adaptation. MRI, with its excellent soft tissue contrast and capacity to probe functional tissue properties, holds great untapped potential for transforming treatment paradigms in radiation therapy. The MR in Radiation Therapy ISMRM Study Group was established to provide a forum within the MR community to discuss the unmet needs and fuel opportunities for further advancement of MRI for radiation therapy applications. During the summer of 2021, the study group organized its first virtual workshop, attended by a diverse international group of clinicians, scientists, and clinical physicists, to explore our predictions for the future of MRI in radiation therapy for the next 25 years. This article reviews the main findings from the event and considers the opportunities and challenges of reaching our vision for the future in this expanding field.

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“…Early work in MRI has shown that diffusion-weighted imaging may be predictive of outcomes [ 36 , 37 ]. Blood volume changes seen on MRI early in the course of RT may predict oncologic outcomes [ 38 ] or even functional outcomes such as dysphagia [ 39 ]. Additional integration of clinical information such as tumor-infiltrating lymphocytes [ 40 ], genomics, or mutational status [ 41 ] may offer predictors that can be incorporated with radiomics data.…”

Section: Developing Areasmentioning

confidence: 99%

Magnetic Resonance Guided Radiotherapy for Head and Neck Cancers

Gharzai

Rosen

Mittal

et al. 2022

JCM

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Radiotherapy is an integral component of head/neck squamous cell carcinomas (HNSCCs) treatment, and technological developments including advances in image-guided radiotherapy over the past decades have offered improvements in the technical treatment of these cancers. Integration of magnetic resonance imaging (MRI) into image guidance through the development of MR-guided radiotherapy (MRgRT) offers further potential for refinement of the techniques by which HNSCCs are treated. This article provides an overview of the literature supporting the current use of MRgRT for HNSCC, challenges with its use, and developing research areas.

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Early MRI Blood Volume Changes in Constrictor Muscles Correlate With Postradiation Dysphagia

Cited by 5 publications

References 26 publications

Advances in and applications of imaging and radiomics in head and neck cancer survivorship

Advances in and applications of imaging and radiomics in head and neck cancer survivorship

The future of MRI in radiation therapy: Challenges and opportunities for the MR community

Magnetic Resonance Guided Radiotherapy for Head and Neck Cancers

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