Association of
            <i>PON1</i>
            Gene Polymorphisms and Enzymatic Activity With Risk of Coronary Artery Disease

Godbole, Charuta; Thaker, Saket; Kerkar, Prafulla; Nadkar, Milind; Gogtay, Nithya J; Thatte, Urmila M

doi:10.2217/fca-2020-0028

Cited by 13 publications

(13 citation statements)

References 26 publications

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“…For the first time, our results provide a comprehensive and updated evaluation of PON-1 arylesterase activity in CAD patients, reviewing all the available studies published over the last twenty years. Indeed, several investigations have been previously focused on the relationship between PON-1 single nucleotide polymorphisms (SNPs) and cardiovascular disease (CVD) [ 31 – 33 ], including CAD [ 7 ]. However, the results reported in these studies were highly variable, with some of them revealing either a significant or a nonsignificant association between genetic variants and disease occurrence.…”

Section: Discussionmentioning

confidence: 99%

Paraoxonase-1 (PON-1) Arylesterase Activity Levels in Patients with Coronary Artery Disease: A Meta-Analysis

et al. 2022

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Aim. To review and compare the PON-1 arylesterase activity between coronary artery disease (CAD) and non-CAD patients. Methods. Data were obtained by searching MEDLINE and Scopus for all investigations published between January 1, 2000 and March 1, 2021 comparing PON-1 arylesterase activity between CAD and controls. Results. Twenty studies, based on 5417 patients, met the inclusion criteria and were included in the analysis. A random effect model revealed that PON-1 arylesterase activity was significantly lower in the CAD group compared to controls ( SMD = – 0.587 , 95 % CI = − 0.776 to -0.339, p < 0.0001 , I 2 = 92.3 % ). In CAD patients, the PON-1 arylesterase activity was significantly higher among CAD patients without diabetes mellitus (DM) compared to those with diabetes (SMD: 0.235, 95% CI: 0.014 to 0.456, p = 0.03 , I 2 = 0 % ). Conclusions. PON-1 activity is significantly lower in CAD patients, and those without DM presented a significantly higher PON-1 arylesterase activity.

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Section: Discussionmentioning

confidence: 99%

Paraoxonase-1 (PON-1) Arylesterase Activity Levels in Patients with Coronary Artery Disease: A Meta-Analysis

et al. 2022

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“…Although the exact mechanisms of these associations have not been thoroughly investigated, the Q192R polymorphism seems to affect the activity of the paraoxonase 1 (PON1) enzyme ( 41 , 42 ). The paraoxonase-1 (PON1) enzyme is one of the proteins constituting HDL-C particles and is responsible for its antioxidant and anti-inflammatory properties ( 43 ).…”

Section: Discussionmentioning

confidence: 99%

The association of the paraoxonase 1 Q192R polymorphism with coronary artery disease (CAD) and cardiometabolic risk factors in Iranian patients suspected of CAD

Darand

Salehi‐Abargouei

Mehrjardi

et al. 2023

Front. Cardiovasc. Med.

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IntroductionThe present study aimed to investigate the association of the paraoxonase 1 (PON1) Q192R polymorphism with coronary artery disease (CAD) and cardiometabolic risk factors in Iranian patients suspected of CAD.MethodsThis cross-sectional study was conducted on 428 patients undergoing angiography. The data related to demographic information and physical activity were collected by valid and reliable questionnaires. The PON-1 genotypes were detected by the polymerase chain reaction-restriction fragment length polymorphism (RFLP-PCR) technique. The Gensini and SYNTAX score, anthropometric measurements, and biochemical and clinical parameters were measured by standard protocols.Results and discussionFindings indicated that the odds of obesity was significantly higher in people with the RR genotype compared to the QQ genotype carriers (OR: 2.95 CI: 1.25–6.93, P = 0.014) and also odds of low high-density lipoprotein cholesterol (HDL-C) was marginally higher (OR: 2.31 CI: 0.97–5.49, P = 0.056). There was no significant association between other CAD risk factors with PON1 Q192R polymorphism (P > 0.05). Further analysis showed a significant interaction between sex and 192QR (P = 0.019) and 192 RR (P = 0.007) genotypes on body mass index (BMI). More specifically, the risk of obesity in men carrying the RR genotype was 3.38 times (OR: 3.38 CI: 1.08–10.58, P = 0.036). Also, a significant joint effect of the RR genotype and sex on HDL-C was seen (P = 0.003). The stratification based on sex showed that the risk of low HDL-C is significantly higher in women carrying the RR genotype (OR: 6.18 CI: 1.21–31.46, P = 0.028). A marginal sex-genotype interaction was also found in the risk of elevated alanine aminotransferase (ALT) (P = 0.057). In summary, the findings showed that the risk of obesity and low HDL-C was higher in people carrying the RR genotype. On the other hand, a Q192R polymorphism-sex interaction was observed on the risk of obesity, elevated ALT, and low HDL-C.

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“… 8 The single nucleotide polymorphisms (SNPs) of PON1 genes are 192QQ and 55LL, which are wild type genotypes, whereas 192QR, 192RR, 55LM and 55MM are mutants. 10 Nearly 200 PON1 SNPs have been identified to date. 11 , 12 …”

Section: Introductionmentioning

confidence: 99%

Paraoxonase gene polymorphisms: Understanding the biochemical and genetic basis of coronary artery disease

Nasreen¹,

Gayathri

2023

Journal of Taibah University Medical Sciences

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Association of PON1 Gene Polymorphisms and Enzymatic Activity With Risk of Coronary Artery Disease

Cited by 13 publications

References 26 publications

Paraoxonase-1 (PON-1) Arylesterase Activity Levels in Patients with Coronary Artery Disease: A Meta-Analysis

Paraoxonase-1 (PON-1) Arylesterase Activity Levels in Patients with Coronary Artery Disease: A Meta-Analysis

The association of the paraoxonase 1 Q192R polymorphism with coronary artery disease (CAD) and cardiometabolic risk factors in Iranian patients suspected of CAD

Paraoxonase gene polymorphisms: Understanding the biochemical and genetic basis of coronary artery disease

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