Paraoxonase-1 (PON-1) Arylesterase Activity Levels in Patients with Coronary Artery Disease: A Meta-Analysis

Zuin, Marco; Trentini, Alessandro; Marsillach, Judit; D’Amuri, Andrea; Bosi, Cristina; Roncon, Loris; Passaro, Angelina; Zuliani, Giovanni; Mackness, Mike; Cervellati, Carlo

doi:10.1155/2022/4264314

Cited by 13 publications

(6 citation statements)

References 42 publications

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“…The results shown in Table (1) showed a high significant decrease with a probability level (P≤ 0.0006) in the activity of aryl esterase in the serums of patients with atherosclerosis (71. The results of the current study agreed with the previous results [27] [28] , which showed that aryl esterase activity was inversely related to the risk of developing cardiovascular diseases, including atherosclerosis, as the results showed a decrease in the concentration of aryl esterase in patients with atherosclerosis compared to healthy subjects, and this is due to the increase in oxidative stress processes in patients, causing an increase in lipid peroxides in the serum, which works to inhibit the enzyme, so its effectiveness decreases in patients [29] Troponin T level:…”

Section: Measuring the Level Of The Aryl Esterasesupporting

confidence: 93%

In Vitro Study of the Effect of Vanillin Derivatives on Aryl Esterase, Troponine and Lipid Profile in Atherosclerosis Patients as Compared to Normal Subjects

Atallah,

Khalid,

Sulaiman

2023

Tikrit J. Pharm. Sci.

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The study describes the effect of vanillin derivative on the activity of aryl esterase in vitro. After that, the Estimated effectiveness of the enzyme aryl esterase, troponin T, and lipids. The research included the collection of 120 blood samples distributed to 60 blood samples of healthy people as a control group and 60 blood samples of patients with atherosclerosis who were diagnosed under the supervision of specialized doctors at Salah Eddin General Hospital / Catheterization Unit. Results showed that the vanillin derivative has an invigorating effect on the activity of aryl esterase, and that the degree of enzyme activation increases with the increase in the concentration of the derivative, while there was lower with a probability level (P≤ 0.0006) in the activity of aryl esterase from the serum of patients with atherosclerosis in addition, a significant increase at the probability level ( P ≤ 0.001) in the level of total cholesterol, triglycerides, LDL-C and VLDL-C, while there was decrease at the probability level (P ≤ 0.0004) in the level of HDL-C. Keywords: Aryl esterase, Vanillin derivative, Lipids, Atherosclerosis.

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Section: Measuring the Level Of The Aryl Esterasesupporting

confidence: 93%

In Vitro Study of the Effect of Vanillin Derivatives on Aryl Esterase, Troponine and Lipid Profile in Atherosclerosis Patients as Compared to Normal Subjects

Atallah,

Khalid,

Sulaiman

2023

Tikrit J. Pharm. Sci.

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“…Paraoxonase-1 (PON-1) is an enzyme synthesized in the liver residing on high-density lipoprotein (HDL) that catalyzes the hydrolysis of various aromatic carboxylic acid esters, organophosphates, and lactones [38]. Paraoxonase-1 has many enzymatic activities, such as lactonase, thiolactonase, arylesterase, and aryldialkylphosphatase (commonly known as paraoxonase) [39]. In humans, a strong negative correlation between PON-1 activity and serum concentrations of lipid oxidation markers has been observed [40].…”

Section: Discussionmentioning

confidence: 99%

Effects of cerium oxide (CeO2) on liver tissue in liver ischemia-reperfusion injury in rats undergoing desflurane anesthesia

Göbüt

Küçük²,

Şengel

et al. 2023

BMC Anesthesiol

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Introduction During liver surgery and transplantation, periods of partial or total vascular occlusion are inevitable and result in ischemia-reperfusion injury (IRI). Nanomedicine uses the latest technology, which has emerged with interdisciplinary effects, such as biomedical sciences, physics, and engineering, to protect and improve human health. Interdisciplinary research has brought along the introduction of antioxidant nanoparticles as potential therapeutics. The goal of this study was to investigate the effects of cerium oxide (CeO2) administration and desflurane anesthesia on liver tissue in liver IR injury. Material and methods Thirty rats were randomly divided into five groups: control (C), ischemia-reperfusion (IR), IR-desflurane (IRD), cerium oxide-ischemia reperfusion (CeO2-IR), and cerium oxide-ischemia reperfusion-desflurane (CeO2-IRD). In the IR, IRD, and CeO2-IRD groups, hepatic ischemia was induced after the porta hepatis was clamped for 120 min, followed by 120 min of reperfusion. Intraperitoneal 0.5 mg/kg CeO2 was administered to the CeO2 groups 30 min before ischemia. Desflurane (6%) was administered to the IRD and CeO2-IRD groups during IR. All groups were sacrificed under anesthesia. Liver tissue samples were examined under a light microscope by staining with hematoxylin-eosin (H&E). Malondialdehyde (MDA) levels, catalase (CAT), glutathione-s-transferase (GST), and arylesterase (ARE) enzyme activities were measured in the tissue samples. Results The IR group had considerably more hydropic degeneration, sinusoidal dilatation, and parenchymal mononuclear cell infiltration than the IRD, CeO2-IR, and CeO2-IRD groups. Catalase and GST enzyme activity were significantly higher in the CeO2-IR group than in the IR group. The MDA levels were found to be significantly lower in the IRD, CeO2-IR, and CeO2-IRD groups than in the IR group. Conclusion Intraperitoneal CeO2 with desflurane reduced oxidative stress and corrected liver damage.

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“…Interestingly, the HDL accessory proteins also accomplish actions in health and disease, including neurological diseases [ 63 , 64 ]. Paraoxonase-1 (PON-1), an accessory protein of HDL, is an enzyme that hydrolyzes oxHDL [ 65 ]. An issue of remarkable importance is to investigate whether PON-1 is also able to hydrolyze oxHDL.…”

Section: Discussionmentioning

confidence: 99%

Oxidized High-Density Lipoprotein Induces Endothelial Fibrosis Promoting Hyperpermeability, Hypotension, and Increased Mortality

Rojas

Prado

Tapía³

et al. 2022

Antioxidants

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During systemic inflammation, reactive oxygen species (ROS) are generated in the bloodstream, producing large amounts of oxidized HDL (oxHDL). OxHDL loses the vascular protective features of native HDL, acquiring detrimental actions. Systemic inflammation promotes endothelial fibrosis, characterized by adhesion protein downregulation and fibrotic-specific gene upregulation, disrupting endothelial monolayer integrity. Severe systemic inflammatory conditions, as found in critically ill patients in the intensive care unit (ICU), exhibit endothelial hyperpermeability, hypotension, and organ hypoperfusion, promoting organ dysfunction and increased mortality. Because endothelial fibrosis disturbs the endothelium, it is proposed that it is the cellular and molecular origin of endothelial hyperpermeability and the subsequent deleterious consequences. However, whether oxHDL is involved in this process is unknown. The aim of this study was to investigate the fibrotic effect of oxHDL on the endothelium, to elucidate the underlying molecular and cellular mechanism, and to determine its effects on vascular permeability, blood pressure, and mortality. The results showed that oxHDL induces endothelial fibrosis through the LOX-1/NOX-2/ROS/NF-κB pathway, TGF-β secretion, and ALK-5/Smad activation. OxHDL-treated rats showed endothelial hyperpermeability, hypotension, and an enhanced risk of death and mortality, which was prevented using an ALK-5 inhibitor and antioxidant diet consumption. Additionally, the ICU patients showed fibrotic endothelial cells, and the resuscitation fluid volume administered correlated with the plasma oxHDL levels associated with an elevated risk of death and mortality. We conclude that oxHDL generates endothelial fibrosis, impacting blood pressure regulation and survival.

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Paraoxonase-1 (PON-1) Arylesterase Activity Levels in Patients with Coronary Artery Disease: A Meta-Analysis

Cited by 13 publications

References 42 publications

In Vitro Study of the Effect of Vanillin Derivatives on Aryl Esterase, Troponine and Lipid Profile in Atherosclerosis Patients as Compared to Normal Subjects

In Vitro Study of the Effect of Vanillin Derivatives on Aryl Esterase, Troponine and Lipid Profile in Atherosclerosis Patients as Compared to Normal Subjects

Effects of cerium oxide (CeO2) on liver tissue in liver ischemia-reperfusion injury in rats undergoing desflurane anesthesia

Oxidized High-Density Lipoprotein Induces Endothelial Fibrosis Promoting Hyperpermeability, Hypotension, and Increased Mortality

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