Paraoxonase gene polymorphisms: Understanding the biochemical and genetic basis of coronary artery disease

Aims: Migraine, a prevalent neurovascular disorder, is marked by repetitive headache episodes. Its complex etiology encompasses biochemical, genetic, and environmental influences, but its exact pathophysiology remains elusive. Recent studies have hinted at a link between migraine and oxidative stress. Hence, this study sought to delve into the correlation between migraine, oxidative stress markers, and lipid profiles. Materials & Methods: This case-control study involved 60 adult migraine patients from Dicle University's Neurology Department in Diyarbakır, Turkey, observed between 2009 and 2010. The control group was age- and gender-matched healthy individuals. Parameters like malondialdehyde (MDA), paraoxonase-1(PON-1), total antioxidant capacity (TAC), and lipid constituents such as total cholesterol (TC), LDL-C, HDL-C, and triglycerides (TG) were measured in both groups. Findings: Migraine sufferers, particularly those with aura, had significantly elevated MDA levels compared to controls (p

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Paraoxonase gene polymorphisms: Understanding the biochemical and genetic basis of coronary artery disease

Cited by 2 publications

References 20 publications

Association of paraoxonase-1 (Q192R) gene polymorphism with coronary artery spasm during cardiac catheterisation in Egyptians

Association of paraoxonase-1 (Q192R) gene polymorphism with coronary artery spasm during cardiac catheterisation in Egyptians

Investigating the Role of Oxidant-Antioxidant Balance in the Etiology of Migraine

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