Effectiveness and Safety of Novel Nutraceutical Formulation Added to Ezetimibe in Statin-Intolerant Hypercholesterolemic Subjects with Moderate-to-High Cardiovascular Risk

Mazza, Alberto; Nicoletti, Mariaceleste; Lenti, Salvatore; Torin, Gioia; Rigatelli, Gianluca; Pellizzato, Marzia; Fratter, Andrea

doi:10.1089/jmf.2020.0019

Cited by 6 publications

(3 citation statements)

References 48 publications

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“…A twelve-week dietary supplementation with bread enriched with (−)-epicatechin and quercetin (0.05%) improved total cholesterol, LDL-cholesterol, triglycerides, and fasting plasma glucose in 156 participants who had at least three of the risk factors for MetS [ 75 ]. Further, the combination therapy (ezetimibe and nutraceutical compound in which quercetin was found) reduced total cholesterol (TC) and LDL-c levels by 25.9% and 38.7%, respectively, among statin-intolerant hypercholesterolemic subjects [ 76 ]. It was found that the lipid-lowering effect of red yeast rice, which was administrated in the therapy, may have modulatory effects on the endogenous synthesis of LDL-c by inhibiting the HMGCR.…”

Section: Clinical Studies On Flavanol Interventions—an Update From Th...mentioning

confidence: 99%

Targeting Cardiovascular Diseases by Flavonols: An Update

Kozłowska

Szostak-Węgierek

2022

Nutrients

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Flavonols are one of the most plentiful flavonoid subclasses found in natural products and are extensively used as dietary supplements. Numerous in vitro and in vivo studies have shown the cardioprotective properties of flavonols, especially quercetin. This group of substances exerts positive impacts primarily due to their antiatherogenic, antithrombotic, and antioxidant activities. The potential of flavonols to promote vasodilation and regulation of apoptotic processes in the endothelium are other beneficial effects on the cardiovascular system. Despite promising experimental findings, randomized controlled trials and meta-analyses have yielded inconsistent results on the influence of these substances on human cardiovascular parameters. Thus, this review aims to summarize the most recent clinical data on the intake of these substances and their effects on the cardiovascular system. The present study will help clinicians and other healthcare workers understand the value of flavonol supplementation in both subjects at risk for cardiovascular disease and patients with cardiovascular diseases.

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Section: Clinical Studies On Flavanol Interventions—an Update From Th...mentioning

confidence: 99%

Targeting Cardiovascular Diseases by Flavonols: An Update

Kozłowska

Szostak-Węgierek

2022

Nutrients

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“…Mazza et al, on the other hand, showed that in statinintolerant patients with hypercholesterolemia and a moderate to high cardiovascular risk, using ezetimibe with a combination of nutraceutics (Monacolin K, berberine Hydrochloride, t-Resveratrol, Quercetin, Chromium) caused a higher reduction of TC and LDL-C, compared to a treatment with ezetimibe alone [42]. The reduction amounted to, respectively, -25.9% vs. 15% (p<0.05), and -38.7% vs. 21% (p<0.05).…”

Section: Annals Of Agricultural and Environmental Medicinementioning

confidence: 99%

Hypolipaemic nutraceutics: red yeast rice and Armolipid, berberine and bergamot

Kłosiewicz−Latoszek

Cybulska

Stós

et al. 2020

Ann Agric Environ Med.

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Introduction. Increased serum cholesterol levels constitute one of the main risk factors for cardiovascular diseases. Statins are a major method for reducing the levels which also lower the risk of cardiovascular events. However, these valuable drugs cannot be used in all patients who need them due to contraindications and intolerance. In such cases, help can be sought from nutraceutics that reduce the serum cholesterol concentration. Since there are numerous products of this type available at drugstores, registered as supplements, there seems to be a need to demonstrate their effectiveness in preventing cardiovascular diseases induced by atherosclerosis. In literature, increasingly more attention is drawn to red yeast rice, Armolipid, berberine and bergamot. Brief description. This article presents knowledge about these nutraceutics based on clinical studies and expert statements relating to their use. The results of clinical studies and metaanalyses have shown that nutraceutics with cholesterol lowering properties, red yeast rice and Armolipid are the most favourable for reducing cardiovascular events. However, the evidence of benefits of berberine and bergamot is not so conclusive. Conclusions. Red yeast rice products and Armolipid may be used as an alternative treatment in statin intolerant patients, especially in combination with ezetimibe. These nutraceutics can be also considered, as an adjunct to diet therapy in primary prevention of cardiovascular diseases in patients with mild and moderate hypercholesterolaemia. The opinion of experts on berberine and bergamot is ambiguous.

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“…Calcium, omega-3 polyunsaturated fatty acids, vitamin D, folic acid, resveratrol, alpha-lipoic acid, zinc, inositol, and probiotic supplements are potentially proven candidates as novel nutraceuticals [ 4 ]. Researchers have evaluated the nutraceutical associated with the drug compound ezetimibe for patients atrisk of elevations of statin level, which further leads to cardiovascular diseases [ 5 ]. The use of a novel nutraceutical in blend with non-steroidal anti-inflammatory drugs (NSAIDs) has been proven a potential candidate for osteoarthritis, thus improving its efficacy and safety for commercial use [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges

et al. 2022

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Nutraceuticals are the nourishing components (hybrid of nutrition and pharmaceuticals) that are biologically active and possess capability for maintaining optimal health and benefits. These products play a significant role in human health care and its endurance, most importantly for the future therapeutic development. Nutraceuticals have received recognition due to their nutritional benefits along with therapeutic effects and safety profile. Nutraceuticals are globally growing in the field of services such as health care promotion, disease reduction, etc. Various drug nutraceutical interactions have also been elaborated with various examples in this review. Several patents on nutraceuticals in agricultural applications and in various diseases have been stated in the last section of review, which confirms the exponential growth of nutraceuticals’ market value. Nutraceuticals have been used not only for nutrition but also as a support therapy for the prevention and treatment of various diseases, such as to reduce side effects of cancer chemotherapy and radiotherapy. Diverse novel nanoformulation approaches tend to overcome challenges involved in formulation development of nutraceuticals. Prior information on various interactions with drugs may help in preventing any deleterious effects of nutraceuticals products. Nanotechnology also leads to the generation of micronized dietary products and other nutraceutical supplements with improved health benefits. In this review article, the latest key findings (clinical studies) on nutraceuticals that show the therapeutic action of nutraceutical’s bioactive molecules on various diseases have also been discussed.

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Effectiveness and Safety of Novel Nutraceutical Formulation Added to Ezetimibe in Statin-Intolerant Hypercholesterolemic Subjects with Moderate-to-High Cardiovascular Risk

Cited by 6 publications

References 48 publications

Targeting Cardiovascular Diseases by Flavonols: An Update

Targeting Cardiovascular Diseases by Flavonols: An Update

Hypolipaemic nutraceutics: red yeast rice and Armolipid, berberine and bergamot

A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges

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