Stereotactic radiosurgery for central neurocytomas: an international multicenter retrospective cohort study

Hung, Yi-Chun; Lee, Cheng-chia; Yang, Huai‐Che; Mohammed, Nasser; Kearns, Kathryn N.; Sun, Shibin; Mathieu, David; Touchette, Charles J; Atik, Ahmet; Grills, I.S.; Squires, Bryan; Ding, Dale; Williams, Brian J.; Yusuf, Mehran; Woo, Shiao Y.; Hanuška, Jaromír; Shiao, Jay C.; Kondziolka, Douglas; Lunsford, L. Dade; Xu, Zhiyuan; Sheehan, Jason P.

doi:10.3171/2020.1.jns191515

Cited by 16 publications

(15 citation statements)

References 35 publications

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“…Previous radiation therapy was a predictor of distant tumor recurrence (p = 0.044). Distant tumor recurrence and spread were observed in a small proportion of patients, underscoring the importance of close post-SRS surveillance of patients with central neurocytoma [21].…”

Section: Discussionmentioning

confidence: 95%

Multiple Solitary Plasmacytoma: A Rare Presentation

Kuchkuntla¹,

Nandu²

2020

J Oncol Res Rev Rep

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Central neurocytoma is considered a neoplasm classified as grade II by the WHO, of intraventricular location, although they can be aggressive. Due to the rare incidence, there are no fixed treatment rules or radiation therapy recommendations. Macroscopic total resection is usually curative, however, it is only achieved in 30-50% of cases due to the central location. Adjuvant treatment for optimal neurocytoma management should be considered. Stereotactic radiosurgery is now increasingly recommended as an adjuvant treatment. A case report of a patient treated with postoperative radiosurgery with high local control is presented, and the literature review is also performed.

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Section: Discussionmentioning

confidence: 95%

Multiple Solitary Plasmacytoma: A Rare Presentation

Kuchkuntla¹,

Nandu²

2020

J Oncol Res Rev Rep

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“…A multicenter retrospective study by Hung et al stated that SRS achieves good tumor control rates with a reasonable complication profile for 60 patients with central neurocytomas. They showed a 13% recurrence rate following SRS with 93% 5-year local control and 89% 5-year progression-free survival [20].…”

Section: Discussionmentioning

confidence: 98%

Clinicopathological features and treatment outcome of central neurocytoma: a single institute experience

Mohamed

Gurusamy

Orz

et al. 2022

Egypt J Neurol Psychiatry Neurosurg

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Background Despite the increased interest in publishing data on central neurocytoma, its management remains controversial. The overall incidence is approximately 0.5% of brain tumors. The reporting of institutional experience is of major need for such category of tumors to increase our knowledge and experience. In this study, we describe the clinical presentation, pathological data, and treatment outcomes of central neurocytoma. Results Medical records of patients with neurocytoma treated in our center from July 2008 to December 2018 were retrospectively reviewed. Extra ventricular neurocytomas were excluded from analysis due to the known aggressive behavior compared to central neurocytoma. Seventeen patients treated at our center as central neurocytoma were included in the study. The frequent clinical presentation was headaches (58.8%) and paresis (35.3%). Ten patients (58.8%) developed symptoms before the age of 30 years. All patients were treated with surgical resection. Gross total resection was performed in 11 cases (64.7%) and subtotal resection was performed in 3 cases (17.7%). Four patients developed disease progression following the first excision (23.5%), for which additional resection was performed. Two patients received fractionated radiotherapy; one after the first resection due to residual disease postoperatively and the other patient following the third excision due to multiple recurrences with radiotherapy doses of 50.4 Gy and 54 Gy, respectively. The median follow-up time was 51 months (range of 14–106). The 5-year progression-free survival was 70 ± 13%. The overall survival for our cohort of patients was 100%. Conclusions Central neurocytoma is a rare tumor of neuronal origin and surgery is the mainstay of treatment with a favorable prognosis. Adjuvant radiotherapy can be offered in patients with residual disease or multiple recurrences, especially in patients with tumors of high MIC-1 LI.

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“…In consideration of pathological grade of the case was II-III, chemotherapy was excluded. Beyond that, Gamma Knife stereotactic radiosurgery (GKSR), as a form of radiation therapy that focuses high-power energy on a small area of the body, achieves good tumor control rates (9). However, the tumor cavity of the case was larger than 30mm, so GKSR therapy was not performed (10).…”

Section: Discussionmentioning

confidence: 99%

Atypical extraventricular neurocytoma: A case report

Zhang

Qin

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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Atypical extraventricular neurocytoma (EVN) is a rare condition characterized by diffuse tumor cell hyperplasia, increased neovascularization, increased necrosis, and aggressive characteristics. A case of a 25-year old man who presented with atypical EVN in his left parietal -occipital flaps is reported.Magnetic resonance imaging (MRI) revealed a well-defined globular mass with heterogeneous signals in the left parietal lobe, and mild perilesional edema. After left parietal craniotomy and tumor excision, pathologic examination of the resected tissue revealed that the lesion was localized mainly in the white matter and imbued with tumor cells possessing round hyperchromatic nuclei with perinuclear halos and increased microvascular proliferation. The patient underwent radiotherapy at 21 st postoperative day. Over the past 26 months, the patient has been regularly followed up, and so far no neurologic deficits have been observed. The latest MRI showed that the tumor bed was stable with slight peritumoral edema. The results of clinical, histopathological and immunohistochemical examinations indicate that atypical EVN is a rare neoplasm with unique radiographic and pathologic characteristics. It possesses more aggressive properties than typical EVN.

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Stereotactic radiosurgery for central neurocytomas: an international multicenter retrospective cohort study

Cited by 16 publications

References 35 publications

Multiple Solitary Plasmacytoma: A Rare Presentation

Multiple Solitary Plasmacytoma: A Rare Presentation

Clinicopathological features and treatment outcome of central neurocytoma: a single institute experience

Atypical extraventricular neurocytoma: A case report

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