Terpenoids from the stems of Celastrus hindsii and their anti-RSV activities

Luo, Dan; Xiong, Si; Li, Qingguo; Jiang, Lin; Niu, Qian-Wen; He, Lijun; Zhang, Yubo; Wang, Guo‐Cai

doi:10.1016/j.fitote.2018.08.018

Cited by 15 publications

(7 citation statements)

References 33 publications

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“…Celastrus hindsii, which belongs to the Celastraceae family, is widely distributed in Asia, especially China [10]. C. hindsii is commonly used as a traditional medicine to diminish inflammation, cancers, and ulcers [11].…”

Section: Introductionmentioning

confidence: 99%

“…C. hindsii is commonly used as a traditional medicine to diminish inflammation, cancers, and ulcers [11]. ese plants contain various bioactive compounds [10,11], which exhibits pharmaceutical effects such as antioxidant [11], antiviral [10], and anticancer activities [12,13]. Considering such medicinal benefits of C. hindsii, these plants can be a promising source of flavonoids.…”

Section: Introductionmentioning

confidence: 99%

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Optimization of Ultrasound-Assisted Extraction of Flavonoids from Celastrus hindsii Leaves Using Response Surface Methodology and Evaluation of Their Antioxidant and Antitumor Activities

Pham

Nguyen

et al. 2020

BioMed Research International

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Celastrus hindsii is a potential source of flavonoids with biological activities. This study aimed to develop an ultrasound-assisted technique for extracting flavonoids from leaves of C. hindsii. Response surface methodology was employed to optimize the extraction conditions for maximizing the total flavonoid content (TFC). A maximum TFC of 23.6 mg QE/g was obtained under the extraction conditions of ultrasonic power of 130 W, extraction temperature of 40°C, extraction time of 29 min, and ethanol concentration of 65%. The flavonoid-rich extracts were then studied for their antioxidant and anticancer activities. The results showed that the C. hindsii leaf extract exhibited potent radical scavenging activities against DPPH (IC50 of 164.85 μg/mL) and ABTS (IC50 of 89.05 μg/mL). The extract also significantly inhibited the growth of 3 cancer cell lines MCF7, A549, and HeLa with the IC50 values of 88.1 μg/mL, 120.4 μg/mL, and 118.4 μg/mL, respectively. Notably, the extract had no cytotoxicity effect on HK2 normal kidney cell line. This study suggests that flavonoid-rich extract is a promising antioxidant and anticancer agent and that ultrasound-assisted extraction is an efficient method for extracting flavonoids from C. hindsii leaves.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Optimization of Ultrasound-Assisted Extraction of Flavonoids from Celastrus hindsii Leaves Using Response Surface Methodology and Evaluation of Their Antioxidant and Antitumor Activities

Pham

Nguyen

et al. 2020

BioMed Research International

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“…In the contrast, celahin D showed the lower one compared to three compounds (Luo et al, 2018). Further isolation of Wikstroemia indica (L.) C.A.…”

Section: Anti-respiratory Syncytial Virus Agentsmentioning

confidence: 75%

“…Three terpenoids 2α-hydroxyabietatriene, celahin D, and vitamin E quinone showed inhibitory activity on reverse transcriptase activity with an IC 50 of approximately 3.13 μM. In the contrast, celahin D showed the lower one compared to three compounds ( Luo et al, 2018 ). Further isolation of Wikstroemia indica (L.) C.A.…”

Section: Natural Products With Reported Activities Against Viral Pneumonia: Focus On Medicinal Plantsmentioning

confidence: 94%

Overview of Viral Pneumonia Associated With Influenza Virus, Respiratory Syncytial Virus, and Coronavirus, and Therapeutics Based on Natural Products of Medicinal Plants

Lin

Chen

et al. 2021

Front. Pharmacol.

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Viral pneumonia has been a serious threat to global health, especially now we have dramatic challenges such as the COVID-19 pandemic. Approximately six million cases of community-acquired pneumonia occur every year, and over 20% of which need hospital admission. Influenza virus, respiratory virus, and coronavirus are the noteworthy causative agents to be investigated based on recent clinical research. Currently, anaphylactic reaction and inflammation induced by antiviral immunity can be incriminated as causative factors for clinicopathological symptoms of viral pneumonia. In this article, we illustrate the structure and related infection mechanisms of these viruses and the current status of antiviral therapies. Owing to a set of antiviral regiments with unsatisfactory clinical effects resulting from side effects, genetic mutation, and growing incidence of resistance, much attention has been paid on medicinal plants as a natural source of antiviral agents. Previous research mainly referred to herbal medicines and plant extracts with curative effects on viral infection models of influenza virus, respiratory virus, and coronavirus. This review summarizes the results of antiviral activities of various medicinal plants and their isolated substances, exclusively focusing on natural products for the treatment of the three types of pathogens that elicit pneumonia. Furthermore, we have introduced several useful screening tools to develop antiviral lead compounds.

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“…As a part of our research to search structural unique and biologically interesting constituents from Chinese medicinal plants, two new pyrone derivatives ( 1 − 2 ), along with five known ones ( 3 − 7 ) were isolated from the leaves of H. monogynum (Figure ). Compound 1 is the first isopropylpyrone in which an isopropyl attached to the C‐6 position of the pyrone.…”

Section: Introductionmentioning

confidence: 99%

Isopropylpyrone and Phenylpyrones from the Leaves of Hypericum monogynum

Zhang

et al. 2020

ChemistrySelect

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A new isopropylpyrone, hypemonone F (1), and a new phenylpyrone, hypemonone G (2), along with five known phenylpyrones, peplidiforone B (3), hypemonone C (4), hypemonone B (5), 3-(1,1-dimethyl-2-propen-1-yl)-4-methoxy-6-phenyl-2Hpyran-2-one (6), hyperenone A (7) were isolated from the leaves of Hypericum monogynum. Their structures were identified on the basis of the spectral data (IR, UV, HRESIMS, and NMR). The absolute configurations of 1 À 4 were determined by electronic circular dichroism and single crystal X-ray analyses. All isolated compounds (1 À 7) were evaluated for their cytotoxic activities on tumor cells (HeLa and HepG2). Compounds 1 À 7 showed cytotoxic activities against HeLa cells with IC 50 values of 28.27 � 2.65 to 89.02 � 2.30 μM, and compounds 2, 3, 6, 7 showed cytotoxic activities against HepG2 cells with IC 50 values of 68.44 � 1.45 to 80.7 � 1.66 μM.[a] Prof.

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Terpenoids from the stems of Celastrus hindsii and their anti-RSV activities

Cited by 15 publications

References 33 publications

Optimization of Ultrasound-Assisted Extraction of Flavonoids from Celastrus hindsii Leaves Using Response Surface Methodology and Evaluation of Their Antioxidant and Antitumor Activities

Optimization of Ultrasound-Assisted Extraction of Flavonoids from Celastrus hindsii Leaves Using Response Surface Methodology and Evaluation of Their Antioxidant and Antitumor Activities

Overview of Viral Pneumonia Associated With Influenza Virus, Respiratory Syncytial Virus, and Coronavirus, and Therapeutics Based on Natural Products of Medicinal Plants

Isopropylpyrone and Phenylpyrones from the Leaves of Hypericum monogynum

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