A new isopropylpyrone, hypemonone F (1), and a new phenylpyrone, hypemonone G (2), along with five known phenylpyrones, peplidiforone B (3), hypemonone C (4), hypemonone B (5), 3-(1,1-dimethyl-2-propen-1-yl)-4-methoxy-6-phenyl-2Hpyran-2-one (6), hyperenone A (7) were isolated from the leaves of Hypericum monogynum. Their structures were identified on the basis of the spectral data (IR, UV, HRESIMS, and NMR). The absolute configurations of 1 À 4 were determined by electronic circular dichroism and single crystal X-ray analyses. All isolated compounds (1 À 7) were evaluated for their cytotoxic activities on tumor cells (HeLa and HepG2). Compounds 1 À 7 showed cytotoxic activities against HeLa cells with IC 50 values of 28.27 � 2.65 to 89.02 � 2.30 μM, and compounds 2, 3, 6, 7 showed cytotoxic activities against HepG2 cells with IC 50 values of 68.44 � 1.45 to 80.7 � 1.66 μM.[a] Prof.
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