Isopropylpyrone and Phenylpyrones from the Leaves of Hypericum monogynum

Abstract

A new isopropylpyrone, hypemonone F (1), and a new phenylpyrone, hypemonone G (2), along with five known phenylpyrones, peplidiforone B (3), hypemonone C (4), hypemonone B (5), 3-(1,1-dimethyl-2-propen-1-yl)-4-methoxy-6-phenyl-2Hpyran-2-one (6), hyperenone A (7) were isolated from the leaves of Hypericum monogynum. Their structures were identified on the basis of the spectral data (IR, UV, HRESIMS, and NMR). The absolute configurations of 1 À 4 were determined by electronic circular dichroism and single crystal X-ray analyses. All isolated compounds (1 À 7) were evaluated for their cytotoxic activities on tumor cells (HeLa and HepG2). Compounds 1 À 7 showed cytotoxic activities against HeLa cells with IC 50 values of 28.27 � 2.65 to 89.02 � 2.30 μM, and compounds 2, 3, 6, 7 showed cytotoxic activities against HepG2 cells with IC 50 values of 68.44 � 1.45 to 80.7 � 1.66 μM.[a] Prof.

Hypericum genus cosmeceutical application – A decade comprehensive review on its multifunctional biological properties

“…1(iii). Although widely cultivated in South Africa, east and southern Asia, Australia, Central America, north-west Europe, and Mauritius, it is mainly distributed throughout China and some places of Japan (Ernst, 2003;Li et al, 2020;Tanaka and Takaishi, 2006). As a traditional folk medicine, this plant has been used for the treatment of dysmenorrhea and other female disorders, cough, hypertension, hepatitis, acute laryngopharyngitis, pertussis, conjunctivitis, rheumatic arthritis, bites of venomous animals, and blunt trauma (Tanaka et al, 2005;Tanaka and Takaishi, 2006;Zhang et al, 2020).…”