3 Clinical pathophysiology and metabolic effects of hypothyroidism

Bürgi, U; König, Max Pierre

doi:10.1016/s0950-351x(88)80054-5

Cited by 9 publications

(7 citation statements)

References 99 publications

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“…Thyroid hormone deficiency is effective on every tissue in the body. The accumulation of hydrophilic molecules, hyaluronic acid and other glycosaminoglycans in interstitial tissue is responsible for oedema in interstitial tissue 30 . Myxoedema and fluid retention are characteristic clinical findings of overt hypothyroidism, so it was hypothesised that SH might also affect the fluid distribution of the body.…”

Section: Discussionmentioning

confidence: 99%

The effect of subclinical hypothyroidism on body composition parameters in children

2020

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Background It's known that overt hypothyroidism increases body fat content and weight. There's limited research about the effect of subclinical hypothyroidism (SH) on body composition in children and the effect of LT4 treatment. We aimed to evaluate body composition parameters in healthy subjects and in children with mild SH (MSH) and determine the effect of LT4 treatment. Methods Sixty‐four healthy children and 32 children with MSH were included. Anthropometric measurements and hormonal parameters were evaluated. Body composition was evaluated using bioelectric impedance analysis (BIA). Patients were put on LT4 treatment. BIA was performed again after 12 months of therapy. Results There was no significant difference between the anthropometric parameters and basal metabolic rate of the healthy children and the MSH group. The percentage of trunk muscle mass (TMM) in the MSH group was lower than in the control group (P < .05). After 12 months of LT4 treatment, the percentage of total fat‐free mass (FFM), TMM and trunk fat‐free mass (TFFM) were increased and percentage of total body fat mass and trunk fat mass were decreased (P < .05). The difference between the percentage of TMM in the MSH group and control group was insignificant after LT4 treatment (P > .05). Conclusions The percentage of TMM in children with MSH was found lower than healthy control group. After LT4 treatment, the percentage of the FFM, TMM and TFFM were increased and the difference between percentage of TMM in children with MSH and healthy controls was insignificant. Our data indicated that MSH might be associated with early changes in body composition parameters.

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Section: Discussionmentioning

confidence: 99%

The effect of subclinical hypothyroidism on body composition parameters in children

2020

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“…The clinical consequence in overt hypothyroidism is the interstitial edema in the skin, but this effect is also demonstrable in striated muscle and heart muscle [12].…”

Section: Introductionmentioning

confidence: 99%

Effect of Subclinical Hypothyroidism on Body Fluid Compartments

Lorenzo¹,

Andréoli²,

Fusco³

et al. 2000

Horm Metab Res

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“…These hormones also play a part in the healing process as they interfere with fibroblast function [2,3] , accelerating the formation of collagen or promoting collagenolysis [4,5] . In several studies of cutaneous healing, it was observed that hypothyroidism could prolong the proliferative phase of healing as well as alter the quality of collagen, forming thinner and smaller collagen fibers [6][7][8] . Thyroxin administration can induce protein synthesis, improving the oxidation and phosphorylation of the mitochondria, thus reversing the negative effects of hypothyroidism on the healing process [9] .…”

Section: Introductionmentioning

confidence: 99%

“…Although the diagnosis of hypothyroidism can be easily established by measuring the thyroid-stimulating hormone (TSH), this test is not routinely done preoperatively, even though it is known that the incidence of hypothyroidism in the general population varies from 0.3 to 7.7% and that of subclinical hypothyroidism from 4.3 to 11% [8][9][10][11][12][13][14][15][16][17][18][19] .…”

Section: Introductionmentioning

confidence: 99%

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Wound Healing in Colonic Anastomosis in Hypothyroidism

Nassif¹,

Greca

Graf

et al. 2009

Eur Surg Res

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Colonic anastomosis healing in hypothyroidism was evaluated. Twenty Wistar rats were separated into two groups: the study group (n = 10), which underwent total thyroidectomy to induce hypothyroidism, and the control group (n = 10). After 10 weeks, hypothyroid status was confirmed by blood tests (p < 0.0001). Three days later, a colonic anastomosis was performed, and the animals were sacrificed 1 week later. The colon containing the anastomosis was resected for bursting strength tests and histological studies. The slides were stained with hematoxylin-eosin and with Sirius red to quantify and classify the collagen. Reduced values were found for the bursting strength test (p = 0.0006) and for collagen density in the experimental group. There was a prevalence of immature type III collagen (p < 0.0001) and a decrease in mature type I collagen (p < 0.0001) in the hypothyroid group.

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3 Clinical pathophysiology and metabolic effects of hypothyroidism

Cited by 9 publications

References 99 publications

The effect of subclinical hypothyroidism on body composition parameters in children

The effect of subclinical hypothyroidism on body composition parameters in children

Effect of Subclinical Hypothyroidism on Body Fluid Compartments

Wound Healing in Colonic Anastomosis in Hypothyroidism

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