Non-invasive Dual-Channel Broadband Diffuse Optical Spectroscopy of Massive Hemorrhage and Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in Swine

Abstract

Dual-channel regional tissue DOS measurements can be used to non-invasively track the formation of hemodynamically distinct tissue compartments during hemorrhage and REBOA. Conventional systemic measures MAP, HR, and SV are uncorrelated with tissue status in inferior (downstream) sites. Multi-compartment DOS may provide a more complete picture of the efficacy of REBOA and similar resuscitation procedures.

Monocular 3D Probe Tracking for Generating Sub-Surface Optical Property Maps from Diffuse Optical Spectroscopic Imaging

“…The ability to generate sub-surface optical property maps from handheld freeform optical probe scanning has major implications in clinical disease screening and treatment effect monitoring. Although handheld biophotonic technologies have been shown to provide clinically relevant quantitative tissue proper-ties in a non-intrusive, safe (light-based) and handheld manner for applications such as breast cancer [3], bone sarcoma [4], and acute hemorrhage treatment [5], the clinical uptake of the technologies is currently limited by the lack of operator freedom, operator-patient interaction, and difficulty of landmark-based measurements for follow-up assessment. The demonstrated robustness to different probe operating speeds shows promise for the use of the technology by different operators, which is a critical characteristic for clinical adoption.…”

“…Diffuse optical spectroscopic imaging (DOSI) quantitatively measures sub-surface interactions of light with tissue for inferring optical properties, more specifically, scattering (μ's) and absorption (μa ) coefficients, which are then used to assess concentrations of bulk absorbing tissue chromophores, primarily oxyhemoglobin (HbO2), deoxyhemoglobin (Hb), water (H2O), and lipid [1]. In combination, these quantities reflect aspects of tissue perfusion, metabolism, hydration and blood volume [2], and provide clinically relevant information for assessing tissue health in applications such as breast cancer [3], bone sarcoma [4], and acute hemorrhage treatment [5].…”

Estudo de anatomia comparada suína por angiotomografia: contribuições para modelos de pesquisa e treinamento em cirurgia vascular e endovascular

“…12,32,33 Porcine models have been employed for development, training, and studies of REBOA. 12,29,32,33 Studies have focused on comparing continuous vs. intermittent [33][34][35] and partial vs. total aortic occlusion, 36 the ideal duration of occlusion, 37 and tissue oxygenation, 38 targeting better results in clinical practice. Our results and the scant published data available suggest that the biological and histochemical repercussions of aortic occlusion in pigs should be judiciously interpreted, since the blood supply to the hind limbs is ensured by anastomoses, such as those between the internal thoracic (mammary) arteries and the epigastric vessels 11 (Figure 4A illustrates the course of the mammary arteries).…”

Multi-modal diffuse optical spectroscopy for high-speed monitoring and wide-area mapping of tissue optical properties and hemodynamics

“…Optically obtained hemodynamic biomarkers have been identified as key indicators of hemorrhage and resuscitation. 15 – 19 While DOSI has been a valuable complement for a wide variety of clinical applications, advancement of the instrumentation to collect multiple modalities and accurately track handpiece position in a single device is important for constrained clinical settings, capturing faster physiological signals, and for rapid visualization of the images corresponding to the physical, mapped area.…”