“…No correlation was demonstrated among age, tumor grade, Ki67 or hormone receptor status, and a positive HER2 FISH result in the current study. Efared et al 10 showed no differences with regard to age ( P = 0.312), grade ( P = 0.127), hormone receptor status ( P = 0.110), and Ki67 ( P = 0.319) between HER2 FISH-positive and negative cases. Rushoff et al, 21 however, showed that histologic grading, hormone receptor status, histologic subtype, age, and nodal status had a significant effect on the FISH HER2 positivity rate using a multiple-testing model.…”