Biological properties and pathogenicity factors of Helicobacter pylori

Исаева, Г. Ш.; Fagoonee, Sharmila

doi:10.23736/s1121-421x.18.02479-0

Cited by 12 publications

(2 citation statements)

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“…Numerous studies have shown that H. pylori infection is the leading bacterial cause of both malignant and non-malignant gastroduodenal diseases and is also involved in extra-gastroduodenal disorders. Among these, the most common disorders are peptic and duodenal ulceration, acute and chronic gastritis (which may lead to atrophic gastritis), and gastric adenocarcinoma (B-cell gastric lymphoma and mucosa-associated lymphoid tissue (MALT) lymphoma) [10,11]. However, most of the risk reduction due to improved socio-economic status (even in the absence of specific preventive strategies) is thought to stem from reduced H. pylori infection rates [12].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Helicobacter pylori Infection and Diagnostic Methods in the Middle East and North Africa Region

et al. 2020

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Background and Objectives: Helicobacter pylori (H. pylori) infection is common worldwide and may cause gastroduodenal complications, including cancer. In this review, we examine the prevalence and distribution of various H. pylori genotypes and the risk factors for H. pylori infection, particularly in the Middle East and North Africa (MENA) region. We also introduce different global screening methods and guidelines and compare them to those currently in use in the MENA region. Materials and Methods: We searched the Google Scholar, PubMed, and Saudi Digital Library (SDL) databases for clinical trials and articles published in English. The data collection was mainly focused on MENA countries. However, for H. pylori genotypes and diagnostic methods, studies conducted in other regions or reporting global practices and guidelines were also included to allow a comparison with those in the MENA region. We also included studies examining the prevalence of H. pylori infection in healthy participants. Results: H. pylori infection is highly prevalent in the MENA region, mainly because of the accumulation of risk factors in developing countries. Herein, we highlight a lack of good quality studies on the prevalence of various H. pylori genotypes in the MENA region as well as a need for standard diagnostic methods and screening guidelines. Due to the complications associated with H. pylori, we recommend routine screening for H. pylori infection in all gastroenterology patients admitted in the MENA region. Conclusion: Concerted effort will first be required to validate affordable, non-invasive, and accurate diagnostic methods and to establish local guidelines with adapted cut-off values for the interpretation of the test results.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Helicobacter pylori Infection and Diagnostic Methods in the Middle East and North Africa Region

et al. 2020

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“…H. pylori genome has more than 30 genes which encode for OMPs, that can be divided into Helicobacter outer membrane proteins (Hop) subgroups. [26][27][28][29] Some of these proteins have been identified. Blood group antigen binding adhesin (BabA), the first discovered, is involved in binding with ABO group (Lewis antigen, expressed in stomach) and leads to the synthesis of proinflammatory cytokines.…”

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confidence: 99%

Diagnosis of Helicobacter pylori infection: a look into molecular aspects of urea breath test

Marinoni¹,

Ribaldone²,

Rosso³

et al. 2019

Minerva Biotecnol

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Helicobacter pylori (H. pylori) is a bacterium that selectively colonizes gastric epithelium in more than 50% people over the world. The infection is usually acquired in early childhood and rarely resolved spontaneously; transmission is mostly person to person, and occurs by fecal-oral or oraloral modality. Diagnosis and antibiotic treatment may lead to eradication of H. pylori, improving the prevention and the outcome of gastric and extragastric diseases. Many tests are currently available for the diagnosis of H. pylori infection and the choice depends on several clinical aspects including symptoms, age, indications for testing, concomitant medications and comorbidities.Invasive tests (i.e. endoscopy with histologic assessment) are considered the gold standard, but they are expensive and should be performed only in an appropriate context. The most common noninvasive tests are urea breath test (UBT), stool antigens test and serology. UBT is non-invasive, quick, safe, accurate and cheap. This test is performed mainly with 13 C and is based on the presence of H. pylori urease, an enzyme that converts urea (labelled with an isotope) into CO2. Labelled CO2 is then exhaled and measured by dedicated spectrophotometers. This review analyses with special emphasis UBT, focusing on its molecular aspects.

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Sialic acid-based strategies for the prevention and treatment of Helicobacter pylori infection: Emerging trends in food industry

Sun

Zhang

Ren

et al. 2020

Critical Reviews in Food Science and Nutrition

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Biological properties and pathogenicity factors of Helicobacter pylori

Cited by 12 publications

References 0 publications

Prevalence of Helicobacter pylori Infection and Diagnostic Methods in the Middle East and North Africa Region

Prevalence of Helicobacter pylori Infection and Diagnostic Methods in the Middle East and North Africa Region

Diagnosis of Helicobacter pylori infection: a look into molecular aspects of urea breath test

Sialic acid-based strategies for the prevention and treatment of Helicobacter pylori infection: Emerging trends in food industry

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