Association of generic health-related quality of life (EQ-5D dimensions) and inactivity with lung function in lung-healthy German adults: results from the KORA studies F4L and Age

Luzak, Agnes; Karrasch, Stefan; Wacker, Margarethe; Thorand, Barbara; Nowak, Dennis; Peters, Annette; Schulz, Holger

doi:10.1007/s11136-017-1763-6

Cited by 4 publications

(3 citation statements)

References 31 publications

(40 reference statements)

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“…Possible reasons might be the fact that some demographic or physical characteristics such as age, gender, and BMI were related to HRQOL [20]. The relationship between lung function and physical health score in this study was in accordance with other studies [21,22]. However, a different report by Abbott and colleagues suggested that %pred FEV 1 was significantly associated with all domains of HRQOL including physical health, psychological state, social relationships and so on in 234 cystic fibrosis patients [13].…”

Section: Discussionsupporting

confidence: 90%

Potential Effects of Lung Function Reduction on Health-Related Quality of Life

Wen

Wang

Zhou

et al. 2019

IJERPH

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Health-related quality of life (HRQOL) was reported to reflect overall quality of life and individual perceptions related to health. Decreased lung function is associated with reduced ventilation and oxygen intake and reported to affect body functions. However, the effect of lung function reduction on HRQOL is still unclear. A total of 8398 retired workers from Dongfeng-Tongji Cohort Study were included in this cross section study. Lung function was measured using an electronic spirometer. HRQOL was evaluated through a questionnaire designed according to the WHOQOL-BREF. The mean of the HRQOL scores of its four domains (physical health, psychological state, social relationships and environment) is the total HRQOL score. A general linear model was used to analyse the association between lung function and HRQOL. In the continuous analysis by the general linear model, FVC was associated with the total HRQOL, physical health domain and social relationships domain scores. In the categorical analysis, there was a linear trend between FVC and the total HRQOL and physical health scores. We also found a similar relationship between FEV1 and HRQOL scores. Further analysis suggested that elevated lung function could improve the scores of pain and discomfort facet and independence facet of physical health domain. The lung function was significantly positively associated with HRQOL in middle-aged and older Chinese.

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Section: Discussionsupporting

confidence: 90%

Potential Effects of Lung Function Reduction on Health-Related Quality of Life

Wen

Wang

Zhou

et al. 2019

IJERPH

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“…Tools to assess HRQoL are also adopted in randomized trials, typically as secondary outcomes, remarking the importance of evaluating the efficacy of novel therapies also in terms of HRQoL improvement. An association between impaired pulmonary function and decreased EQ-5D has been described in SSc [6], in patients with other respiratory diseases [7], and also in lung-healthy individuals [8]. Nevertheless, the extent of contribution given by changes in PFTs over time to the evolution of HRQoL in SSc patients is largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Lung function is associated with minimal EQ-5D changes over time in patients with systemic sclerosis

et al. 2020

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In systemic sclerosis (SSc) therapeutic efforts are often directed to prevent progressive respiratory impairment, but it is unclear to what extent changes in pulmonary function tests (PFTs) are associated with health-related quality of life (HRQoL). The aim of our study is to evaluate how modifications in PFTs contribute to longitudinal variations in HRQoL, assessed through the multidimensional questionnaire EQ-5D, in patients with SSc. We included SSc patients with forced vital capacity (FVC%), diffusing capacity of the lungs for carbon monoxide (DLCO%) and EQ-5D assessed in at least two visits. The EQ-5D consists of two parts, a utility score ranging from − 0.59 to 1, and a 0-100 Visual Analogue Scale (VAS). Higher values represent better health. The association between changes in FVC% and DLCO%, and evolution of EQ-5D over time, was investigated using generalized estimating equations. Three hundred seventy-eight patients were included, accounting for a total of 1619 measurements. The models showed that improvement in FVC% is significantly associated with increase in both utility score (β = 0.001; 95% CI 0.000 to 0.002; p = 0.003) and VAS over time (β = 0.188; 95% CI 0.111 to 0.264; p < 0.001). Moreover, improvement in DLCO% is longitudinally associated with increase in utility score (β = 0.001; 95% CI 0.000 to 0.002; p = 0.038), while the results for VAS were non-significant (β = 0.020; 95% CI-0.079 to 0.120; p = 0.690). We show that change in PFTs has a significant, although minor, impact on HRQoL as measured by EQ-5D in SSc. Key Points • In patients with SSc, changes in PFTs have a significant, although minor, impact on HRQoL. • In patients with SSc-ILD, the perception of HRQoL is nearly not influenced by changes in pulmonary function. • The use of generic questionnaires might not be sensitive enough to evaluate the impact on quality of life of therapies targeting specific SSc manifestations.

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“…In recent studies, physical activity has shown association with slower age-related reductions of the forced expiratory volume in 1s in adults [10]. Decrease in FEV1 means lung disease is getting worse [11]. Furthermore, studies among sedentary and subjects performing exercises there is a significant increase in parameters and improved lung diffusion capacity among exercise performing subjects [12].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Lung Function Test among Ballooning and Pursuing Lip Exercise

Choudhary

Devi

Priya

2021

JPRI

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Introduction: Lung function tests have been routinely taken for diseased people such as COPD, asthma patients. Exercise and food habits play a vital role in improvement in lung function among these people. Hence, the current study is to assess the lung function parameters among the population performing lip and ballooning exercises. Materials and Methods: The present study was carried out among the participants with the age of 18- 25 years from saveetha dental college. 45 healthy volunteers were divided into three groups. Each group consists of 15 individuals. Group 1: Control; Group 2: Ballooning exercise subjects; Group 3: Pursuing lip exercise individuals. RMS Helios spirometer was used to measure lung volumes and capacities like FVC, FEV1, PEFR, PEF 25-75, FEV3. Statistical analysis was done using SPSS software, student‘t’ test. P value of less than or equal to 0.05 was considered to be as statistically significant. Results: FEV1/FVC is statistically significant among lip exercises (88.61±12.03) but insignificant among ballooning exercises than control individuals (97.61±6.32). FEF25-75 is statistically more significant among pursuing lip exercise (2.65±1.74) than ballooning and control individuals. FVC is statistically more significant among ballooning (1.99±0.27) than pursuing lip exercise and control individuals. Conclusion: It is evident that the subjects performing ballooning exercise have significant increase in lung capacity in comparison with the subjects pursuing lip exercise.Regular exercise produces a positive effect on the lung by increasing the pulmonary capacities.The present study revealed that regular breathing exercise has an important role in determining and improving lung volumes and capacities.

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Association of generic health-related quality of life (EQ-5D dimensions) and inactivity with lung function in lung-healthy German adults: results from the KORA studies F4L and Age

Abstract: Problems with mobility or usual activities, and inactivity were associated with slightly lower spirometric parameters in lung-healthy adults, suggesting a relationship between perceived physical functioning and volumetric lung function.

Cited by 4 publications

References 31 publications

Potential Effects of Lung Function Reduction on Health-Related Quality of Life

Potential Effects of Lung Function Reduction on Health-Related Quality of Life

Lung function is associated with minimal EQ-5D changes over time in patients with systemic sclerosis

Comparative Study of Lung Function Test among Ballooning and Pursuing Lip Exercise

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