Potential Effects of Lung Function Reduction on Health-Related Quality of Life

Wen, Yuhan; Wang, Dongming; Zhou, Min; Zhou, Yun; Guo, Yanjun; Chen, Weihong

doi:10.3390/ijerph16020260

Cited by 12 publications

(11 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the current study, pigs with lower ReHS had higher respiration rate. Respiratory disease reduces the efficiency of the lungs, lowering O2 and increasing CO2 levels in the blood [61,62]. To keep the balance, animals increase their respiration rate.…”

Section: Discussionmentioning

confidence: 99%

A Comprehensive Monitoring System for Health Status and Behavior of Pigs Under Different Environmental Conditions Using Vision and Audio Technologies

Lagua,

Mun,

Ampode

et al. 2023

Preprint

View full text Add to dashboard Cite

This study aimed to assess the feasibility of employing audio and vision technologies as an integrated monitoring system to monitor the health and behavior of pigs under different environmental conditions and to associate these factors. A total of 81 growing pigs ((Landrace x Largewhite) x Duroc) with distinct weight categories (10.47 ± 2.57 kg and 28.81 ± 5.03 kg) were distributed into two distinct housing conditions: Control (characterized by low NH3 levels and low stocking density) and Treatment (marked by elevated NH3 levels and varying stocking densities). Each house was installed with a SoundTalks monitor for automated daily evaluation of respiratory health status (ReHS), and a camera with a microphone to facilitate manual tracking of respiratory symptoms and behavioral patterns. Results showed that the Treatment group encountered significantly high room temperature, NH3 concentration, and carbon dioxide levels, resulting in compromised growth performance—a phenomenon further exacerbated in high stocking density conditions. Pigs within the treatment exhibited increases (p &lt; 0.05) in lateral and total lying behaviors, and incidences of ear and tail injuries, increases screaming frequency, conjunctivitis incidences, coughing frequency, elevated respiration rates, and a decrease in ReHS. The environmental conditions affect the behavior and health of the pigs. Moreover, the behavioral patterns of the pigs are associated with their health conditions. The SoundTalks system did not trigger any warnings during the experimental period. Nevertheless, trend analysis indicated a significant reduction in respiratory health in the treatment. In conclusion, this study underscores the efficacy of merging audio and visual technologies to holistically monitor pig health and behavior, enabling enhanced management strategies. Findings emphasize that monitoring the ReHS trend serves as a pivotal marker for identifying respiratory health problems, complementing the system's innate alarm functions.

show abstract

Section: Discussionmentioning

confidence: 99%

A Comprehensive Monitoring System for Health Status and Behavior of Pigs Under Different Environmental Conditions Using Vision and Audio Technologies

Lagua,

Mun,

Ampode

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Decreases in lung function are associated with declines in both physical health and quality of life (1,2). Obesity is associated with impairment in lung function, measured by decreases in both volume and flow (3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Obesity-Associated Alterations in Lung Function in Mice Measured with Head-Out Plethysmography

Bruggink

Pederson

Kentch

et al. 2022

Preprint

View full text Add to dashboard Cite

Declines in lung function worsen quality of life and increase the risk of mortality. Obesity and non-alcoholic fatty liver disease are associated with worsened lung function. To investigate this association, we assessed lung function in lean and diet-induced obese conscious mice using our newly developed leak-free head-out plethysmography system. Obesity was associated with increased volume (P<0.0001), minute ventilation (volume per minute; P<0.0001), mid-expiratory flow (flow rate at 50% expiratory volume; P<0.0001), end-inspiratory pause (pause at end of inspiration; P<0.0001) and decreased expiratory time (P<0.0001). We next compared the response to methacholine (0, 25, 50, 100 mg/ml in PBS flow 0.2ml/30sec) measured using our head-out plethysmography system with forced oscillation technique (using the standard flexiVent system) measures taken in the same mice. Many of the measures gathered using head-out plethysmography were associated with measures collected using the forced oscillation technique. Minute ventilation was most significantly associated with maximal airway resistance, maximal airway elastance, tissue damping, and tissue elastance (r=-0.59 P<0.0001; r=-0.54 P<0.005; r=-0.48 P<0.005; r=-0.40 P<0.005 respectively). Volume, corrected for energy expenditure, was most significantly associated with maximal resistance of the conducting airways (r=-0.57 P<0.0001). Although fatty liver is associated with changes in lung function, we found neither hepatic vagotomy nor knocking down obesity-induced hepatic GABA production improved lung function in obese mice. Still, our head-out plethysmography system is ideal for assessing the response to interventions aimed at improving obesity-associated declines in lung function.

show abstract

“…Pulmonary vital capacity (PVC) can be captured during the use of an incentive spirometer that encourages post-operative training of lung capacity during a convalescent period. Furthermore, forced vital capacity (FVC) is associated with total health-related quality of life [6] and peak air flow is a statistically significant indicator in predicting mortality in both genders [7]. If health preventive care guidelines include a routine assessment of respiratory function in elderly populations, public health agencies may be able to detect associated comorbidities, including maladaptive psychosocial and emotional behaviors resulting from a change in emotional regulation.…”

Section: Introductionmentioning

confidence: 99%