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Paclitaxel is a promising drug in the treatment of different solid tumors. It exhibits nonlinear pharmacokinetics, particularly when administered as a constant rate infusion for shorter duration (e.g., 3 h). Because of the nonlinearity, relatively small changes in dose may lead to large changes in peak plasma concentration and total drug exposure. The study was conducted to evaluate the pharmacokinetics of different doses of paclitaxel administered intravenously as an infusion. A prospective study was conducted in 23 cancer patients aged between 28 and 74 years, treated with paclitaxel (130, 200, 230, and 260 mg/m2) over 3 h as constant rate infusion. Plasma samples were collected from all patients at 0, 1, and 3 h and for five patients at 5 and 13 h and paclitaxel concentrations were determined using high-performance liquid chromatography method. The overall mean clearance was found to be 47.5847 ± 142.028 l/h; the mean volume of distribution was 142.028 ± 73.438 l; mean elimination rate constant was 0.336 ± 0.002/h; mean half-life was 2.086 ± 0.009 h; mean area under the curve (AUC) was 5.5917 ± 2.707 mg/ml*h; and the mean of mean residence time was 2.980 ± 0.0131 h. Paclitaxel showed nonlinear kinetics and the pharmacokinetic parameters calculated were similar to those quoted in the literature. The peak plasma concentration at 130 mg dose level was 2 μ/ml, but an increase in dose was not associated with proportional increase in plasma concentration. No significant difference was found between pharmacokinetic parameters such as clearance, volume of distribution, and AUC at different dose levels.

Tecoma stans is a flowering plant belonging to the family Bignoniaceae. It is the floral emblem of the Bahamas. Abutilon indicum belongs to the family Malvaceae. It is also called Indian Mallow. Tecoma stans and Abutilon indicumhave antimicrobial activity and can be used in producing antibiotics. There is an urgent need to produce new antibiotics as there is an increase in the development of pathogen resistant drugs. The aim of this study was to compare the antimicrobial activity of ethanolic extract of Tecoma stansand Abutilonindicum leaves. E.faecalis bacteria were maintained in nutrient agar slopes. The powder of the two herbs, were subjected to extraction by Soxhlet extractor and was concentrated to dry residue by Agar well diffusion method. The nutrient broth was inoculated with bacterial strains. The culture was adjusted to 0.5McFarland turbidity standard. Lawn culture was done in Muller-Hinton agar plate and then the plates were dried. A 6 mm diameter well is bored for different concentrations. The extracts were introduced into the well and allowed to stand for 24 hrs. The antibacterial activity was determined by measuring the zone of inhibition. The present finding on the antimicrobial potential of Abutilon indicum and Tecoma stands showed that the two plants have growth inhibitory activity against oral pathogen E. faecalis. Abutilon indicum has a zone of inhibition greater than Tecoma stans. Abutilon indicum exhibited better activity compared to Tecoma stans.

Background and Aim: Dementia is a group of symptoms characterized by memory loss, judgemental loss, forgetfulness. Dementia cannot be cured; but can be prevented. There are seven stages of Dementia, no cognitive decline being the first stage to very severe cognitive decline being the seventh stage. Healthy lifestyle is important for lower risk of Dementia. Smoking, consumption of alcohol, negative thinking, depression, stress, anxiety, lack of sleep, unhealthy diet causes Dementia. Diet plays a very important role in prevention of dementia; foods such as red meat, sugar, fatty foods can increase the risk of dementia whereas foods rich in fibres, fruits can reduce the risk of Dementia. The main aim of this study is to assess the knowledge about lifestyle and dementia. Materials and Methods: This is a cross sectional survey. 121 adolescents of Saveetha Dental College, Chennai participated in the survey which was conducted through Google forms in February 2021. The questionnaire consisted of 19 questions. The data was analyzed with the help of SPSS software and chi-square test was done for the correlation between gender and awareness. Chi-square test was done for the correlation of gender with awareness among the population. ‘p-value’ was calculated and value < 0.05 was considered as significant. Results: Out of that 62 were females and 59 were males. Females were more aware about healthy lifestyles and its connection with dementia than males. 92.56% of people were aware that physical activity promotes a healthy brain. 69.2% agreed that depression can increase risk of Dementia. Majority of them agreed that physical exercise can promote a healthy brain. Conclusion: This study revealed that lifestyle is highly associated with dementia among adolescents. Healthy lifestyle leads to lower risk of dementia even if there’s high genetic risk. Females were aware about the diet which is healthy for lower risk of dementia and more smoking affects the memory. However, most of the people were neutral about the relation between BMI and Dementia.

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