Quantification of coronary low-attenuation plaque volume for long-term prediction of cardiac events and reclassification of patients

Deseive, Simon; Straub, R; Kupke, M.; Broersen, Alexander; Kitslaar, Pieter H.; Maßberg, Steffen; Hadamitzky, Martin; Hausleiter, Jörg

doi:10.1016/j.jcct.2018.01.002

Cited by 16 publications

(9 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They studied 3,158 enrolled patients (mean age: 66±11 years, 70% male), the follow-up was a mean Table 2). 85,90,[141][142][143] However, technical protocols for CCTA (e.g., slice thickness) and the admixture of event types are quite variable and, as such, assessing progression using quantitative plaque measurement should be considered for research purposes, as this time.…”

Section: Atherosclerotic Plaque Progression / Regressionmentioning

confidence: 99%

Society of Cardiovascular Computed Tomography / North American Society of Cardiovascular Imaging – Expert Consensus Document on Coronary CT Imaging of Atherosclerotic Plaque

Shaw

Blankstein

Bax

et al. 2021

Journal of Cardiovascular Computed Tomography

142

View full text Add to dashboard Cite

Section: Atherosclerotic Plaque Progression / Regressionmentioning

confidence: 99%

Society of Cardiovascular Computed Tomography / North American Society of Cardiovascular Imaging – Expert Consensus Document on Coronary CT Imaging of Atherosclerotic Plaque

Shaw

Blankstein

Bax

et al. 2021

Journal of Cardiovascular Computed Tomography

142

View full text Add to dashboard Cite

“…Many papers have showed, that volumetric plaque analysis has additive information regarding CAD severity, disease progression and prognostication. [1][2][3][4][5] However, Symons et al indicated that there are significant variations in plaque volumes within 30 days even when the same scanner settings are used. Hence, significantly larger sample sizes are needed to achieve statistical significance due to the large test-retest variation.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 However, it seems, that even among readers with considerable experience, there is substantial variation in contouring which leads to differences in plaque volumes. Unfortunately, this difference is largest in case of low-attenuation noncalcified plaque volume, which is currently of major research interest as it correlates with multiple clinical outcomes, [1][2][3][4][5] and therefore is seen as a potential pharmaceutical target. 6,7 Radiomic analysis is a promising new technique which may have the potential to increase the diagnostic accuracy of coronary CTA to identify vulnerable.…”

Section: Discussionmentioning

confidence: 99%

“…Results indicate that plaque volumes have additive information regarding CAD severity, disease progression and prognostication beyond the clinically interpreted qualitative characteristics of the disease. [1][2][3][4][5] New drug trials have even defined changes in CT angiography (CTA) derived plaques volumes as surrogate clinical end-points to test the efficacy of novel lipid lowering therapies. 6,7 Atherosclerotic lesions with adverse plaque characteristics (APC) are major targets of novel therapies, as these have been shown to greatly increase the risk of future adverse cardiac events.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of vessel wall segmentation on volumetric and radiomic parameters of coronary plaques with adverse characteristics

Kolossváry

Jávorszky

Karády

et al. 2021

Journal of Cardiovascular Computed Tomography

View full text Add to dashboard Cite

Background: Quantitative coronary plaque parameters are increasingly being utilized as surrogate endpoints of pharmaceutical trials. However, little is known whether differences in segmentation significantly alter parameter values. Methods: Overall, 100 coronary plaques with adverse imaging characteristics were segmented automatically, by two experts (R 1-R 2) and three nonexperts (R 3-R 5). Low attenuation noncalcified (LANCP), noncalcified and calcified plaque volume were calculated and 4310 radiomic features were extracted. Intraclass correlation coefficient (ICC) values were calculated between the segmentations. Results: ICC values between expert readers were 0.84 [

show abstract

“…Napkin-ring sign was defined as low-attenuation area adjacent to the coronary lumen, surrounded by higher attenuation rim <130 HU (1,14). Low-attenuation plaque was defined as a lesion with a CT density ≤30 HU (15). Spotty calcification was defined as calcific lesions <3 mm in diameter (16).…”

Section: Coronary Cta Analysismentioning

confidence: 99%

Increased serum bile acid level is associated with high-risk coronary artery plaques in an asymptomatic population detected by coronary computed tomography angiography

Zhang¹,

Chen²,

Xiang³

et al. 2019

J Thorac Dis

View full text Add to dashboard Cite

Background: There are limited data on the association between serum total bile acid level and coronary plaque characteristics. This study investigated the relationship between serum total bile acid level and the severity of coronary stenosis and coronary plaque features in an asymptomatic population using coronary computed tomography angiography (CTA). Methods: A total of 1,137 consecutive participants with no known coronary artery disease (CAD) undergoing CTA as part of a general routine health evaluation were recruited. Serum total bile acid level and clinical parameters were assayed. Coronary stenosis and high-risk plaques features (napkin-ring sign, low-attenuation plaque, spotty calcification, positive remodelling) were evaluated. Associations between serum total bile acid concentration and high-risk coronary plaques was tested through univariate and multivariate analyses.Results: A total of 101 high-risk coronary plaques subjects and 93 controls were eligible for study inclusion.The severity of coronary artery stenosis and high-risk coronary plaques increased with serum total bile acid level quartiles (all P<0.001). The independent predictor of high-risk coronary plaques in multivariate analysis was serum total bile acid level (P<0.001). Receiver operating characteristic (ROC) confirmed that serum total bile acid concentration significantly differentiated high-risk coronary plaques [the area under the curve (AUC) =0.876; P<0.001, with a sensitivity of 87.13% and a specificity of 86.02%].Conclusions: Higher serum total bile acid level was associated with the severity of coronary artery stenosis and high-risk coronary artery plaques detected by CTA in asymptomatic populations.

show abstract

Quantification of coronary low-attenuation plaque volume for long-term prediction of cardiac events and reclassification of patients

Cited by 16 publications

References 33 publications

Society of Cardiovascular Computed Tomography / North American Society of Cardiovascular Imaging – Expert Consensus Document on Coronary CT Imaging of Atherosclerotic Plaque

Society of Cardiovascular Computed Tomography / North American Society of Cardiovascular Imaging – Expert Consensus Document on Coronary CT Imaging of Atherosclerotic Plaque

Effect of vessel wall segmentation on volumetric and radiomic parameters of coronary plaques with adverse characteristics

Increased serum bile acid level is associated with high-risk coronary artery plaques in an asymptomatic population detected by coronary computed tomography angiography

Contact Info

Product

Resources

About