Increased serum bile acid level is associated with high-risk coronary artery plaques in an asymptomatic population detected by coronary computed tomography angiography

Abstract

Background: There are limited data on the association between serum total bile acid level and coronary plaque characteristics. This study investigated the relationship between serum total bile acid level and the severity of coronary stenosis and coronary plaque features in an asymptomatic population using coronary computed tomography angiography (CTA). Methods: A total of 1,137 consecutive participants with no known coronary artery disease (CAD) undergoing CTA as part of a general routine health evaluation were recruited. Serum total bile acid level and clinical parameters were assayed. Coronary stenosis and high-risk plaques features (napkin-ring sign, low-attenuation plaque, spotty calcification, positive remodelling) were evaluated. Associations between serum total bile acid concentration and high-risk coronary plaques was tested through univariate and multivariate analyses.Results: A total of 101 high-risk coronary plaques subjects and 93 controls were eligible for study inclusion.The severity of coronary artery stenosis and high-risk coronary plaques increased with serum total bile acid level quartiles (all P<0.001). The independent predictor of high-risk coronary plaques in multivariate analysis was serum total bile acid level (P<0.001). Receiver operating characteristic (ROC) confirmed that serum total bile acid concentration significantly differentiated high-risk coronary plaques [the area under the curve (AUC) =0.876; P<0.001, with a sensitivity of 87.13% and a specificity of 86.02%].Conclusions: Higher serum total bile acid level was associated with the severity of coronary artery stenosis and high-risk coronary artery plaques detected by CTA in asymptomatic populations.

Antihypertensive effect and underlying mechanism of tripeptide NCW on spontaneously hypertensive rats using metabolomics analysis

“…31 Serum TBA is also independently related to the coronary heart disease. 32,33 Research by Wu et al has suggested that cholic acid could decrease aldosterone production, increase corticosterone production, and increase the vasoconstrictor responses to norepinephrine by repressing the gene expression of 11β-HSD2 and CYP11B2, thereby causing…”

Myocardial Infarction and Coronary Artery Disease in Menopausal Women With Type 2 Diabetes Mellitus Negatively Correlate With Total Serum Bile Acids

“…In a study based on coronary computed tomography angiography (CTA), a higher circulating TBA level was found to be an independent predictor of coronary plaque instability. The authors proposed that high TBA levels may be associated with the severity of coronary artery stenosis and risk coronary artery plaque detected by CTA (18). In another study on the role of TBA in the progression of CAD in the overall population, also using spline analysis, the presence and severity of TBA and CAD showed an L-shaped relationship, and the breakpoint was close to the upper limit of the normal TBA level (10 µmol/L).…”

Combined Metabolomics and Machine Learning Algorithms to Explore Metabolic Biomarkers for Diagnosis of Acute Myocardial Ischemia

“…Previous studies have reported a relationship between serum bile acid and cardiovascular conditions, including atherosclerosis, obesity, and metabolic diseases [28]. Zhang BC et al found that higher serum total bile acid level was an independent predictor of high-risk coronary plaques in asymptomatic individuals [29], which indicated that serum bile acid level might be forecast the AMI and the occurrence of SCD. It is noteworthy that in the seven essential metabolites, there are three bile acids (cholic acid, glycocholic acid, and glycoursodeoxycholic acid) changes in serum of AMI according present study.…”