“…The development of pharmaceutical forms begins with the preformulation process, which establishes the physical and chemical, pharmaceutical and technological, pharmacological and toxicological features of substances [ 1 ]. As an active pharmaceutical ingredient, miconazole nitrate (MN) is a broad spectrum antifungal agent which has already been studied in the form of mucoadhesive tablets, polymeric matrices (chitosan, gelatine, gum arabic, alginate, carbopol or acrylic resins), microgels, nano-lipid gels or nano-vesicles formulated to treat oral or vaginal candidiasis [ 2 , 3 , 4 , 5 , 6 , 7 ]. In addition to its antifungal activity, MN also has an antimicrobial action—the imidazole class, which makes it frequently applied on skin mucosa to heal fungal infections [ 8 ].…”