Development of Dermal Films Containing Miconazole Nitrate

Abstract

This study aims to develop new antifungal dermal films based on their mechanical properties (elongation, adhesion, behaviour towards vapour moisture) and the in vitro availability of miconazole nitrate, used as a pharmaceutical active ingredient in various concentrations. The three polymeric films prepared were translucent or shiny, with the surface of 63.585 cm2, 0.20–0.30 mm thickness, and content of miconazole nitrate of 3.931 or 15.726 mg·cm2. The mechanical resistance and elongation tests demonstrated that the two films based on hydroxyethyl cellulose (HEC) polymer were more elastic than the one prepared with hydroxypropyl methylcellulose (HPMC). The vapour water absorption and vapour water loss capacity of the films revealed that the HPMC film did not dry very well in the process of preparation by the evaporation of the solvent technique, unlike the HEC films that jellified more evenly in water and had higher drying capacity at 40 °C. The in vitro availability of miconazole nitrate from dermal films was evaluated using the Franz diffusion cell method, through a synthetic membrane (Ø 25 mm × 0.45 µm) and acceptor media with pH 7.4 (phosphate buffer and sodium lauryl sulphate 0.045%), resulting a release rate of up to 70%.

Alginate Oligosaccharides Affect Mechanical Properties and Antifungal Activity of Alginate Buccal Films with Posaconazole

“…It was observed that SI was ALG concentration-dependent -formulation P3 with high ALG concentration possessed higher SI properties. Similarly, Sarheed et al noted that swelling ability was increased with the Folding endurance was measured to determine the rupturing resistance of designed buccal films, and, in all formulations, it was over 100 times, exhibiting good flexibility [18].…”

“…In addition, it was observed that placebo formulations (P1-P4) were characterized by higher TS, E%, and E values than POS-loaded formulations (F1-F4), proving that the addition of the drug substance weakens mechanical properties. Folding endurance was measured to determine the rupturing resistance of designed buccal films, and, in all formulations, it was over 100 times, exhibiting good flexibility [18].…”

Evaluation of Miconazole Nitrate Permeability Through Biological Membrane From Dermal Systems

“…The increasing number of stress conditions caused by the diversification of activities conducted in modern society, associated with the occurrence of the corresponding pollution factors and the diversity of microbial agents, in particular caused by the increased mobility of people all over the world, led, in addition to the appearance of new diseases, to the occurrence and the diversification of fungal infections. The development of pharmaceutical forms with miconazole nitrate (MN) for external use can bring various benefits to patients presenting resistance to classic antifungal forms because of the fact that the active drug lasts longer in the tissue, acting as a slow release product [7,8]. Repeated administration leads to an accumulating effect of multiple doses in the stratum corneum, which causes the disappearance of fungal infection [6,28].…”

Compatibility Study of Four Binary Combinations of Active Ingredients for Dermal Film Forming Systems

“…Recently, in situ film-forming systems (on the skin, after spreading in a thin layer) -FFSs which form a film on the skin after spreading in a thin layer, have been developed as a new approach to be used as an alternative to both conventional and transdermal topical formulations [12]. In this paper, four pharmaceutical substances were selected as potential active ingredients ( Figure 1) that could be useful in the form of film-forming systems with dermal and/or transdermal delivery: adapalene (ADA) [23,84], levofloxacin (LEV) [36,69], meloxicam (MEL) [16], and miconazole nitrate (MIC) [10]. These therapeutic agents have some significant physicochemical properties (Table I) based on which they can be individually used to treat various skin diseases: skin candidiasis, acne vulgaris, other skin infections, etc.…”