location at a particular time. Some of the conditions under which pulsatile drug delivery system is positive include duodenal ulcer, cardiovascular disease, arthritis, asthma, diabetes, neurological disorder, cancer, hypertension, and hypercholesterolemia. Pulsatile drug delivery systems are essentially time-controlled drug delivery systems in which the lag time is regulated independently of environmental factors such as pH, enzymes, gastrointestinal motility, etc. The theory justification for the use of pulsatile release is for drugs where a continuous release of drugs is not needed, i.e. a zero-order release. Drug administration in chronopharmacotherapy is coordinated with biological rhythms to achieve full therapeutic effect and minimize harm to the patient. This drug delivery system is designed to distribute drugs in accordance with body clock. The pulse must be designed in such a way as to achieve a total and rapid release after the lag time. Pulsatile drug delivery is therefore one device that provides strong promises of benefit to patients suffering from chronic conditions such as arthritis, asthma, hypertension by delivering medication at the right time, right place and in appropriate quantities. In recent pharmaceutical applications involving pulsatile delivery; multi-particulate dosage forms (e. g. pellets) over single-unit dosage forms are gaining more popularity. On the basis of methodologies, various pulsatile technologies have been developed, including ACCU-BREAKTM, AQUALON, CODAS ®, PRODAS ®, SODAS ®, MINITABS ®, DIFFUCAPS ®, OROS ® etc.
The objective of this study was to develop a mucoadhesive buccal patch of Ivabradine hydrochloride using mucoadhesive polymers such as carbopol, poloxamer, and HPMC 15LV. During this study polyvinylpyrrolidone, ethyl cellulose considered as a thickening agent or rate controlling polymer. A total number of five formulations were prepared by a solvent evaporation method. The prepared mucoadhesive patches were evaluated for in-vitro dissolution, drug content, folding endurance, mucoadhesive strength, swelling index, and drug-polymer interaction study. From the present study, it found that the mean thickness of the buccal polymeric patches increased with an increase in the amount of polymer percent. Percent swelling index determined at 2, 4, 6 and 8 hrs increased with time and with an increase in the polymer. The in-vitro study was performed by phosphate buffer PH 6.8 in Franz diffusion cell. During the study, it was also found that an increase in the amount of polymer retarded the release of the drug. Formulation F3 released 100% of the drug in 10 hrs of time. There was no such interaction found between drug and excipients.
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