Pulsatile Drug Delivery System: A Formulation Approach for Treatment of Diseases

Abstract

location at a particular time. Some of the conditions under which pulsatile drug delivery system is positive include duodenal ulcer, cardiovascular disease, arthritis, asthma, diabetes, neurological disorder, cancer, hypertension, and hypercholesterolemia. Pulsatile drug delivery systems are essentially time-controlled drug delivery systems in which the lag time is regulated independently of environmental factors such as pH, enzymes, gastrointestinal motility, etc. The theory justification for the use of pulsatile release is for drugs where a continuous release of drugs is not needed, i.e. a zero-order release. Drug administration in chronopharmacotherapy is coordinated with biological rhythms to achieve full therapeutic effect and minimize harm to the patient. This drug delivery system is designed to distribute drugs in accordance with body clock. The pulse must be designed in such a way as to achieve a total and rapid release after the lag time.
 Pulsatile drug delivery is therefore one device that provides strong promises of benefit to patients suffering from chronic conditions such as arthritis, asthma, hypertension by delivering medication at the right time, right place and in appropriate quantities. In recent pharmaceutical applications involving pulsatile delivery; multi-particulate dosage forms (e. g. pellets) over single-unit dosage forms are gaining more popularity. On the basis of methodologies, various pulsatile technologies have been developed, including ACCU-BREAKTM, AQUALON, CODAS ®, PRODAS ®, SODAS ®, MINITABS ®, DIFFUCAPS ®, OROS ® etc.

A developed composite hard-gelatin capsules: delayed-release enteric properties

“…Capsules are placed in the artificial environment at 37 °C, and the release of the medicinally active ingredient is measured. Capsules filled with acetaminophen powder as an active ingredient and the release rate of capsules were studied and compared with the literature [ 11 ]. Acetaminophen is widely using as a pyretic and analgesic [ 12 ].…”

“…But in the second and third samples, purple color change was observed due to the presence of live cells, after dissolve in DMSO solution we can measured in an ELISA reader So conclude that there is no cell toxicity that causes the death of live cells. For calculated the percentage of live cells we use formulation that shown below [ 11 , 13 ]. 100 × average absorbance of control samples / average absorbance of treated samples = percentage of the live cells

Figure 10 Dehydration of the cell wall of living cells and turning it into purple formazan color.

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A current era in pulsatile drug delivery system: Drug journey based on chronobiology

“…After that, the inner reservoir core rapidly releases the drug [ 17 ]. Asthma, hypertension, joint inflammation, and ulcer patients may benefit from pulsatile drug delivery [ 18 ].…”

Formulation Development and Evaluation of Chronomodulated Drug Delivery System by Zafirlukast

“…The dip is particularly pronounced in people with asthma, because bronchoconstriction and exacerbation of symptoms vary in a circadian fashion, a sharp increase in asthmatic attacks during early morning hours. For such conditions a drug delivery system administered at bedtime, but releasing the drug during morning hours, would be an ideal one [10].…”