Corrigendum to “Young-Adult Male Rats’ Vulnerability to Chronic Mild Stress Is Reflected by Anxious-Like instead of Depressive-Like Behaviors”

Herrera-Pérez, José Jaime; Venus, Benítez-Coronel; Jiménez-Rubio, Graciela; Hernández-Hernández, Olivia Tania; Martı́nez-Mota, Lucı́a

doi:10.1155/2017/8952079

Cited by 3 publications

(3 citation statements)

References 1 publication

(1 reference statement)

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“…Additional work is needed to determine whether chronic alBST knockdown of GLP1R alters basal metabolism, caloric efficiency, core body temperature, sympathetic outflow, and/or home cage locomotor activity. We considered the possibility that the mild to moderate stress associated with behavioral testing suppressed body weight gain in CTRL rats (José Jaime et al, 2016;Herrera-Perez et al, 2017) more than in GLP1R-KD rats. However, body weight gain divergence was apparent within 2 weeks after AAV injection, before behavioral testing began.…”

Section: Discussionmentioning

confidence: 99%

Chronic Suppression of Glucagon-Like Peptide-1 Receptor (GLP1R) mRNA Translation in the Rat Bed Nucleus of the Stria Terminalis Reduces Anxiety-Like Behavior and Stress-Induced Hypophagia, But Prolongs Stress-Induced Elevation of Plasma Corticosterone

et al. 2019

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The anterior lateral bed nucleus of the stria terminalis (alBST) expresses glucagon-like peptide-1 receptors (GLP1Rs) and receives input from caudal brainstem GLP1 neurons. GLP1 administered centrally reduces food intake and increases anxiety-like behavior and plasma corticosterone (cort) levels in rats, whereas central GLP1R antagonism has opposite effects. Anxiogenic threats and other stressors robustly activate c-fos expression in both GLP1-producing neurons and also in neurons within alBST subregions expressing GLP1R. To examine the functional role of GLP1R signaling within the alBST, adult male Sprague Dawley rats received bilateral alBST-targeted injections of an adeno-associated virus (AAV) vector expressing short hairpin RNA (shRNA) to knock down the translation of GLP1R mRNA (GLP1R-KD rats), or similar injections of a control AAV (CTRL rats). In situ hybridization revealed that GLP1R mRNA is expressed in a subset of GABAergic alBST neurons, and quantitative real-time PCR confirmed that GLP1R-KD rats displayed a significant 60% reduction in translatable GLP1R mRNA. Compared with CTRL rats, GLP1R-KD rats gained more body weight over time and displayed less anxiety-like behavior, including a loss of light-enhanced acoustic startle and less stress-induced hypophagia. Conversely, while baseline plasma cort levels were similar in GLP1R-KD and CTRL rats, GLP1R-KD rats displayed a prolonged stress-induced elevation of plasma cort levels. GLP1R-KD and CTRL rats displayed similar home cage food intake and a similar hypophagic response to systemic Exendin-4, a GLP1R agonist that crosses the blood-brain barrier. We conclude that GLP1R expressed within the alBST contributes to multiple behavioral responses to anxiogenic threats, yet also serves to limit the plasma cort response to acute stress.

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Section: Discussionmentioning

confidence: 99%

Chronic Suppression of Glucagon-Like Peptide-1 Receptor (GLP1R) mRNA Translation in the Rat Bed Nucleus of the Stria Terminalis Reduces Anxiety-Like Behavior and Stress-Induced Hypophagia, But Prolongs Stress-Induced Elevation of Plasma Corticosterone

et al. 2019

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“…Moreover, animals exposed to the CUS protocol spent significantly less time in the open arms of the plus maze in comparison to animals that were not submitted to this stress protocol. Most studies that use CUS protocols report weight decreases [51,[73][74][75] and increased anxiety-related defense behaviors [74,75].…”

Section: Discussionmentioning

confidence: 99%

Social isolation and social support at adulthood affect epigenetic mechanisms, brain-derived neurotrophic factor levels and behavior of chronically stressed rats

Borges

Freitas

Antoniazzi

et al. 2019

Behavioural Brain Research

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“…Finalmente, embora algumas pesquisas demonstrem que o CMS pode ter um efeito de queda na preferência por soluções adocicadas (e.g., Bessa, 2009;Stepanichev, 2016), outras pesquisas, assim como no presente estudo, não encontraram os mesmos efeitos de anedonia (e.g., Herrera-Pérez et al, 2016;Fonseca Jr. et al, 2015). Além disso, algumas pesquisas com CMS que encontraram efeitos sobre a aprendizagem encontram também efeito de queda na preferência por sacarose (e.g.…”

Section: Discussionunclassified

Efeitos do Estresse Crônico Moderado sobre o Desempenho de Ratos Wistar em Tarefas de Aprendizagem

Pansarim

Schmidt

2019

Inter. Psicol.

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As pesquisas sobre o efeito do estresse sobre a aprendizagem de não humanos apresentam resultados contraditórios. Este estudo investigou os efeitos de um modelo de estresse crônico moderado (CMS) sobre o desempenho de ratos em duas tarefas de aprendizagem: uma discriminação visual simultânea e uma aprendizagem espacial em labirinto aquático. Dez ratos Wistar machos foram divididos em grupo experimental (GE, exposto ao CMS) e grupo controle (GC). Após exposição do GE ao CMS (três semanas), ambos os grupos passaram por uma tarefa de discriminação visual e pela tarefa de aprendizagem espacial no labirinto aquático de Morris (MWM), além de testes de preferência por solução de sacarose. O CMS pode ter reduzido o ganho de peso e dificultado a aprendizagem de discriminação visual do GE, sem alterações na preferência por sacarose e no MWM. De acordo com os resultados do presente estudo e da literatura em geral, os efeitos do CMS sobre a aprendizagem podem depender de sua duração e da complexidade da tarefa.

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Corrigendum to “Young-Adult Male Rats’ Vulnerability to Chronic Mild Stress Is Reflected by Anxious-Like instead of Depressive-Like Behaviors”

Cited by 3 publications

References 1 publication

Chronic Suppression of Glucagon-Like Peptide-1 Receptor (GLP1R) mRNA Translation in the Rat Bed Nucleus of the Stria Terminalis Reduces Anxiety-Like Behavior and Stress-Induced Hypophagia, But Prolongs Stress-Induced Elevation of Plasma Corticosterone

Chronic Suppression of Glucagon-Like Peptide-1 Receptor (GLP1R) mRNA Translation in the Rat Bed Nucleus of the Stria Terminalis Reduces Anxiety-Like Behavior and Stress-Induced Hypophagia, But Prolongs Stress-Induced Elevation of Plasma Corticosterone

Social isolation and social support at adulthood affect epigenetic mechanisms, brain-derived neurotrophic factor levels and behavior of chronically stressed rats

Efeitos do Estresse Crônico Moderado sobre o Desempenho de Ratos Wistar em Tarefas de Aprendizagem

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