Social isolation and social support at adulthood affect epigenetic mechanisms, brain-derived neurotrophic factor levels and behavior of chronically stressed rats

Borges, Juliano Viana; Freitas, Betânia Souza de; Antoniazzi, Vinicius; Santos, Cristophod de Souza dos; Vedovelli, Kelem; Pires, Vivian Naziaseno; Paludo, L.; Lima, Maria Noêmia Martins de; Bromberg, Elke

doi:10.1016/j.bbr.2019.03.025

Cited by 42 publications

(30 citation statements)

References 91 publications

(118 reference statements)

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“…In line with the marked comorbidity which exists between depression and anxiety (Nelemans et al, 2017;Sangenstedt et al, 2017;Steudte-Schmiedgen et al, 2017), this study sought to evaluate the effect of CSI upon the animals' exploration of the EPM. Taken together, the results of the present study align with those of previous studies which show CSI to produce an anxiogenic profile on the EPM (Pellow et al, 1985;Papp et al, 2016;Bavley et al, 2017;Biala et al, 2017;Sun et al, 2017;Viana Borges et al, 2019). According to some authors, male adolescent rats exhibited less exploration of the open arms and lower levels of locomotor activity on the EPM, thus demonstrating a reaction to stress.…”

Section: Discussionsupporting

confidence: 92%

Anhedonic Type Behavior and Anxiety Profile of Wistar-UIS Rats Subjected to Chronic Social Isolation

Acero-Castillo

Ardila-Figueroa

Oliveira

2021

Front. Behav. Neurosci.

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Chronic Social Isolation (CSI) is a model of prolonged stress employed in a variety of studies to induce depression and anxious behavior in rats. The present study aims to evaluate the effect of CSI on male Wistar rats in terms of “anhedonic-type” behavior in the Sucrose Preference Test (SPT) and anxiogenic profile in the elevated-plus-maze (EPM) test, as well as evaluating the effect of resocialization upon sucrose consumption. A total of 24 adolescent male Wistar rats were evaluated. The animals were housed either together (communally) or socially isolated for 21 days, and then exposed for four consecutive days to the SPT test [water vs. a 32% sucrose solution (SS)]. Four days later, they were again subjected to the SPT test (32% vs. 0.7% SS), and then tested on the EPM apparatus 3 days later. Following the completion of the anxiogenic profile of the model, the animals were resocialized for 72 h and then re-tested once again using the SPT (32% vs. 0.7% SS). Twenty-four hours after this final consumption, the animals were euthanized to record the weight of their adrenal glands (AG). It was found that exposure to CSI produces anhedonic-type behavior and an anxiogenic profile in adolescent male rats, as evidenced in both the SPT and EPM tests, as well as in the animals’ physiological stress response. It was also demonstrated that resocialization does not reverse the anhedonic-type behavior, nor the physiological response to stress.

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Section: Discussionsupporting

confidence: 92%

Anhedonic Type Behavior and Anxiety Profile of Wistar-UIS Rats Subjected to Chronic Social Isolation

Acero-Castillo

Ardila-Figueroa

Oliveira

2021

Front. Behav. Neurosci.

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“…The lack of specific ERG alteration in resilient mice is surprising given that resilience to social stress is perceived as an adaptative mechanism involving molecular activations in pathways allowing mice to cope with chronic stress and exhibit adaptative behavioral responses 43,46 . Overall, our findings are consistent with the notion that social stress induces a wide range of adaptative responses 47,48 , not only in the brain, but also in peripheral organs and support the use of ERG to detect these alterations in the retina of males susceptible to social stress.…”

Section: Discussionsupporting

confidence: 89%

Sex-specific retinal anomalies induced by chronic social stress in mice

Arsenault

Lavigne

Mansouri

et al. 2020

Preprint

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Major depressive disorder (MDD) is one of the most common consequences of chronic stress. Still, there is currently no reliable biomarker to detect individuals at risk to develop MDD. Recently, the retina emerged as an effective way to approach the brain and investigate psychiatric disorders with the use of the electroretinogram (ERG). In this study, cones and rods ERGs were performed in male and female mice before and after chronic social defeat stress (CSDS). Mice were then divided as susceptible or resilient to stress. Significant results were only observed in rods ERGs. In males, susceptible mice showed prolonged a-wave implicit times at baseline that were shortened after CSDS. The a-wave was also decreased in both susceptible and resilient male mice after CSDS. In females, rod a-waves were shorter in susceptible than in control mice after CSDS resulting from the latter demonstrating delayed a-waves. Baseline ERGs were able to predict – to some extent – the expression of susceptibility and resilience before stress exposition in male and female mice. Overall, our findings suggest that retinal activity is a presumptive biomarker of stress response and that the ERG could potentially serve as a predicting tool of the stress response in mice.

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“…Moreover, in rats, single immobilization stress can downregulate Bdnf exon I and IV, which is positively related with the decreased histone H3 acetylation at these promoters [142]. Altered acetylation levels of specific histone residues, such as H3K9, H3K14, and H4K12, at the promoters of Bdnf isoforms were also detected in stress models [143][144][145]. In contrast, HDAC-induced histone deacetylation was found in the stress-related downregulation of BDNF in some brain regions of rats [146].…”

Section: Histone Modification and Bdnfmentioning

confidence: 96%

The Relationships Between Stress, Mental Disorders, and Epigenetic Regulation of BDNF

Zhang

Wang

Sun

2020

IJMS

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Brain-derived neurotrophic factor (BDNF), a critical member of the neurotrophic family, plays an important role in multiple stress-related mental disorders. Although alterations in BDNF in multiple brain regions of individuals experiencing stress have been demonstrated in previous studies, it appears that a set of elements are involved in the complex regulation. In this review, we summarize the specific brain regions with altered BDNF expression during stress exposure. How various environmental factors, including both physical and psychological stress, affect the expression of BDNF in specific brain regions are further summarized. Moreover, epigenetic regulation of BDNF, including DNA methylation, histone modification, and noncoding RNA, in response to diverse types of stress, as well as sex differences in the sensitivity of BDNF to the stress response, is also summarized. Clarification of the underlying role of BDNF in the stress process will promote our understanding of the pathology of stress-linked mental disorders and provide a potent target for the future treatment of stress-related illness.

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Social isolation and social support at adulthood affect epigenetic mechanisms, brain-derived neurotrophic factor levels and behavior of chronically stressed rats

Cited by 42 publications

References 91 publications

Anhedonic Type Behavior and Anxiety Profile of Wistar-UIS Rats Subjected to Chronic Social Isolation

Anhedonic Type Behavior and Anxiety Profile of Wistar-UIS Rats Subjected to Chronic Social Isolation

Sex-specific retinal anomalies induced by chronic social stress in mice

The Relationships Between Stress, Mental Disorders, and Epigenetic Regulation of BDNF

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