Frequency of Toxocara spp. antibodies in umbilical cords of newborns attended atthe University Hospital in Southern Brazil and factors associated with infection

Santos, Paula Costa; Telmo, Paula Lima; Lehmann, Lis Maurente; Lorenzi, Carolina; Hirsch, Carolina Domingues; Mattos, Gabriela Torres; Klafke, Gabriel Baracy; Berne, Maria Elisabeth Aires; Gonçalves, Carla Vitola; Scaini, Carlos James

doi:10.1016/j.actatropica.2017.02.003

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…This coinfection was associated with neonates with low birth weights. 48,49 Frequent contact with soil or with dogs and cats has been identified as a risk for human Toxocara infection, especially in children. 18,29,31,33,36,40 According to Colli et al, 27 contact with the soils of recreational areas of schools is a higher risk of Toxocara infection in children than frequent contact with the soils of public squares.…”

Section: Frequency and Characteristics Of Human Infections Due To Toxocaramentioning

confidence: 99%

Human Toxocariasis: 2010 to 2020 Contributions from Brazilian Researchers

Chieffi¹,

Lescano²,

Fonseca³

et al. 2021

RRTM

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Section: Frequency and Characteristics Of Human Infections Due To Toxocaramentioning

confidence: 99%

Human Toxocariasis: 2010 to 2020 Contributions from Brazilian Researchers

Chieffi¹,

Lescano²,

Fonseca³

et al. 2021

RRTM

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“…Toxocariasis is a widespread zoonotic disease, Toxocara spp eggs that are sources of infection for humans are often found contaminating the environment, the main zoonotic specie that cause infection are Toxocara canis (Leon et al, 2020, Fialho andCorrêa, 2016). Toxocara canis prevalence rates, in humans vary among different populations, ranging from 6.4% among pregnant women (Santos et al, 2015), to 20% among neonates (Santos et al, 2017) and from 43.9% to 50.6% among children (Araújo et al, 2020;Schoenardie et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Cyclosporine A increases the intensity of Toxocara canis infection in swiss mice

et al. 2022

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Toxocariasis is a zoonotic disease of worldwide distribution. The connection between parasitic diseases and conditions that depress the immune system, such as the use of immunosuppressive drugs, has been studied. The purpose of this study was to evaluate the effect of Cyclosporine A (CsA) on the intensity of infection, humoral response and gene transcription of interleukins IL-4, IL-10 and IL-12 in mice experimentally infected with Toxocara canis. To this end, mice were divided into two groups treated with CsA (G1: 10 mg/Kg and G2: 50 mg/kg), the G3 and G4 group received PBS. After the last administration of the drug or PBS (orally every 48 hours for 15 days), groups G1, G2 and G3 were inoculated with 1200 eggs of T. canis. Was collected blood samples on days zero, 15 and 30 days post-inoculation (PI), for ELISA test and the mice were euthanized 30 days PI. The organs and striated muscle tissue were collected for the recovery of larvae. The splenocytes were analyzed by RT-PCR. The intensity of infection in the mice treated with 50 mg/kg of CsA was 65.5% higher than in the control group (p=0.001). An analysis of the kinetics of anti-Toxocara antibody revealed that the groups treated with CsA showed significantly higher mean levels of antibodies on day 15 PI. The transcription of the three tested interleukins showed no statistical difference between G2 and G3 (control). It was concluded that the immunosuppression triggered by CsA (50 mg/Kg) favored the establishment of a larger number of T. canis larvae without, however, altering immunoglobulin production and IL-4, IL-10 and IL-12 transcription on day 30 PI.

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“…The possibility of Toxocara transmission, together with favorable environmental conditions, is a serious risk to public health (Capuano & Rocha, 2006;Santos et al 2017). The nematode Toxocara spp.…”

Section: Introductionmentioning

confidence: 99%

Helminth eggs with zoonotic potential in the vicinity of public schools in southern Brazil

Mello

Nizoli

Ferraz

et al. 2020

Rev. Bras. Parasitol. Vet.

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The aim of this study was to evaluate environmental contamination by helminth eggs with zoonotic potential that were found in dog feces in the vicinity of elementary schools. Seventy-nine samples of dog feces were collected from 28 municipal schools located in five neighborhoods in Pelotas, Rio Grande do Sul (RS), Brazil. The samples were processed using the Willis-Mollay technique and analyzed using an optical microscope (40X), to identify any parasite eggs present. All neighborhoods were positive and 74.7% of the samples exhibited one or more helminth genera. The agent with the highest prevalence was Ancylostoma spp. (93.2%), followed by Trichuris spp. (18.6%), Toxocara spp. (11.9%) and Toxascaris (1.7%). These data show that there is a need for greater care towards controlling these helminths with zoonotic potential, including responsible pet ownership and daily activities to clean and collect dog feces in the vicinity of schools, because these are places where children play and study.

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Frequency of Toxocara spp. antibodies in umbilical cords of newborns attended atthe University Hospital in Southern Brazil and factors associated with infection

Cited by 4 publications

References 23 publications

Human Toxocariasis: 2010 to 2020 Contributions from Brazilian Researchers

Human Toxocariasis: 2010 to 2020 Contributions from Brazilian Researchers

Cyclosporine A increases the intensity of Toxocara canis infection in swiss mice

Helminth eggs with zoonotic potential in the vicinity of public schools in southern Brazil

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