Assessment of ionic liquids' toxicity through the inhibition of acylase I activity on a microflow system

Azevedo, Ana M.O.; Pereira, Sarah A.P.; Passos, Marieta L.C.; Costa, Susana P.F.; Pinto, Paula C.A.G.; Araújo, André R. T. S.; Saraiva, M. Lúcia M.F.S.

doi:10.1016/j.chemosphere.2016.12.138

Cited by 16 publications

(7 citation statements)

References 56 publications

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“…Side chain lengths of C 1 –C 4 had no bactericidal effects but increasing side chain lengths to C 6 –C 16 were associated with decreasing MICs ( L. monocytogenes C 6 : 5000 mg/L–C 16 : 1.76 mg/L; E. coli C 6 : 1250 mg/L–C 16 : 3.39 mg/L; P. syringae C 6 : 468 mg/L–C 16 : 3.39 mg/L). Furthermore, the side chain effect was also seen in the enzyme inhibition test (C 8 : 10,000 mg/L–C 16 : 50 mg/L), demonstrating good accordance with bacterial and enzymatic toxicity data ( Figure 2 ) [ 14 , 43 , 44 ].…”

Section: Resultssupporting

confidence: 74%

Virucidal or Not Virucidal? That Is the Question—Predictability of Ionic Liquid’s Virucidal Potential in Biological Test Systems

Sommer

Fister

Gundolf

et al. 2018

IJMS

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For three decades now, ionic liquids (ILs), organic salts comprising only ions, have emerged as a new class of pharmaceuticals. Although recognition of the antimicrobial effects of ILs is growing rapidly, there is almost nothing known about their possible virucidal activities. This probably reflects the paucity of understanding virus inactivation. In this study, we performed a systematic analysis to determine the effect of specific structural motifs of ILs on three different biological test systems (viruses, bacteria and enzymes). Overall, the effects of 27 different ILs on two non-enveloped and one enveloped virus (P100, MS2 and Phi6), two Gram negative and one Gram positive bacteria (E. coli, P. syringae and L. monocytogenes) and one enzyme (Taq DNA polymerase) were investigated. Results show that while some ILs were virucidal, no clear structure activity relationships (SARs) could be identified for the non-enveloped viruses P100 and MS2. However, for the first time, a correlation has been demonstrated between the effects of ILs on enveloped viruses, bacteria and enzyme inhibition. These identified SARs serve as a sound starting point for further studies.

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Section: Resultssupporting

confidence: 74%

Virucidal or Not Virucidal? That Is the Question—Predictability of Ionic Liquid’s Virucidal Potential in Biological Test Systems

Sommer

Fister

Gundolf

et al. 2018

IJMS

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“…Due to the increasing interest in ILs biological and antimicrobial characteristics, different enzyme inhibition assays have been established as a simple and fast pre-screening method for the determination of the toxicological potential of ILs [ 31 , 32 , 33 , 34 ]. In this study, an established method based on a qPCR assay was used, which has been applied for the determination of the toxic potential of pyrithione-ILs [ 10 ], fatty-acid-ILs [ 9 ] and for the determination of ILs with special structural motifs, such as increasing side-chain length, anion chaotropicity and others [ 8 ].…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial and Virucidal Potential of Morpholinium-Based Ionic Liquids

Michalski

Sommer

Rossmanith

et al. 2023

IJMS

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Witnessed by the ongoing spread of antimicrobial resistant bacteria as well as the recent global pandemic of the SARS-CoV-2 virus, the development of new disinfection strategies is of great importance, and novel substance classes as effective antimicrobials and virucides are urgently needed. Ionic liquids (ILs), low-melting salts, have been already recognized as efficient antimicrobial agents with prospects for antiviral potential. In this study, we examined the antiviral activity of 12 morpholinium based herbicidal ionic liquids with a tripartite test system, including enzyme inhibition tests, virucidal activity determination against five model viruses and activity against five bacterial species. The antimicrobial and enzymatic tests confirmed that the inhibiting activity of ILs corresponds with the number of long alkyl side chains and that [Dec2Mor]+ based ILs are promising candidates as novel antimicrobials. The virucidal tests showed that ILs antiviral activity depends on the type and structure of the virus, revealing enveloped Phi6 phage as highly susceptible to the ILs action, while the non-enveloped phages PRD1 and MS2 proved completely resistant to ionic liquids. Furthermore, a comparison of results obtained for P100 and P001 phages demonstrated for the first time that the susceptibility of viruses to ionic liquids can be dependent on differences in the phage tail structure.

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“…They are usually charged, depending on the varying chemical or physical conditions, such as pH, temperature, and pressure. Many ILs are similar to cationic surfactants, 106,164 which can destroy proteins.…”

Section: Therapeutic Components and Mechanismmentioning

confidence: 99%

Ionic liquids revolutionizing biomedicine: recent advances and emerging opportunities

Hu,

Xing,

Yue

et al. 2023

Chem. Soc. Rev.

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Assessment of ionic liquids' toxicity through the inhibition of acylase I activity on a microflow system

Cited by 16 publications

References 56 publications

Virucidal or Not Virucidal? That Is the Question—Predictability of Ionic Liquid’s Virucidal Potential in Biological Test Systems

Virucidal or Not Virucidal? That Is the Question—Predictability of Ionic Liquid’s Virucidal Potential in Biological Test Systems

Antimicrobial and Virucidal Potential of Morpholinium-Based Ionic Liquids

Ionic liquids revolutionizing biomedicine: recent advances and emerging opportunities

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