Modelling primary blast lung injury: current capability and future direction

Scott, Timothy; Hulse, Elspeth J.; Haque, Mainul; Kirkman, Emrys; Hardman, Jonathan G.; Mahoney, Peter F.

doi:10.1136/jramc-2016-000678

Cited by 7 publications

(8 citation statements)

References 26 publications

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“…The permeability of alveoli-capillary membrane increased significantly, and a large number of proteins and cells exude through the blood-gas barrier. 10,[15][16][17] As seen in this study, shock waves induced by our self-made device could cause mice lung damage, which may lead to a variety of pathophysiological changes, including hemorrhage, edema, and inflammatory cells infiltration in the lung.…”

Section: Discussionmentioning

confidence: 99%

A novel animal model of primary blast lung injury and its pathological changes in mice

Meng

Lu²,

Zhang³

et al. 2022

J Trauma Acute Care Surg

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Section: Discussionmentioning

confidence: 99%

A novel animal model of primary blast lung injury and its pathological changes in mice

Meng

Lu²,

Zhang³

et al. 2022

J Trauma Acute Care Surg

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“…However, as with all forms of acute lung injury, cardinal rules apply, with mechanical ventilation involving limiting plateau pressure < 30 cm H 2 O, limiting tidal volume to < 6 ml.kg −1 predicted body weight and preventing barotrauma, volutrauma and ventilator‐induced lung injury. In primary blast lung injury, there is some evidence that airway pressure release ventilation may be advantageous over other modes [6]. Airway pressure release ventilation is a pressure‐controlled mode that is time cycled and delivers almost continuous positive pressure which is then intermittently released for a short period at a lower pressure.…”

Section: Respiratory Supportmentioning

confidence: 99%

“…In primary blast lung injury, there is some evidence that airway pressure release ventilation may be advantageous over other modes [6]. Airway pressure release ventilation is a pressure-controlled mode that is time cycled and delivers almost continuous positive pressure which is then intermittently released for a short period at a lower pressure.…”

Section: Respiratory Supportmentioning

confidence: 99%

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Management of thoracic trauma

et al. 2022

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Managing major thoracic trauma begins with identifying and anticipating injuries associated with the mechanism of injury. The key aims are to reduce early mortality and the impact of associated complications to expedite recovery and restore the patient to their pre-injury state. While imaging is imperative to identify the extent of thoracic trauma, some pathology may require immediate treatment. The majority can be managed with adequate pleural drainage, but respiratory failure and poor gas exchange may require either non-invasive or invasive ventilation. Ventilation strategies to protect from complications such as barotrauma, volutrauma and ventilator-induced lung injury are important to consider. The management of pain is vital in reducing respiratory complications. A multimodal strategy using local, regional and systemic analgesia may mitigate respiratory side effects of opioid use. With optimal pain management, physiotherapy can be fully utilised to reduce respiratory complications and enhance early recovery. Thoracic surgeons should be consulted early for consideration of surgical management of specific injuries. With a greater understanding of the mechanisms of injury and the appropriate use of available resources, favourable outcomes can be reached in this cohort of patients. Overall, a multidisciplinary and holistic approach results in the best patient outcomes.

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“…As discussed in this paper recently,3 one such area where computational modelling could be of benefit is in improving the management of primary blast lung injury (PBLI). PBLI is part of a syndrome of injury resulting to a high explosive shock wave.…”

Section: Introductionmentioning

confidence: 99%

Primary blast lung injury simulator: a new computerised model

et al. 2018

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Mathematical modelling and computational simulation are becoming increasingly important tools in many fields of medicine where in vivo studies are expensive, difficult or impractical. This is particularly the case with primary blast lung injury, and in this paper, we give a brief overview of mathematical models before describing how we generated our blast lung injury simulator and describe some early results of its use.

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Modelling primary blast lung injury: current capability and future direction

Cited by 7 publications

References 26 publications

A novel animal model of primary blast lung injury and its pathological changes in mice

A novel animal model of primary blast lung injury and its pathological changes in mice

Management of thoracic trauma

Primary blast lung injury simulator: a new computerised model

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