Measurements in wound healing with observations on the effects of topical agents on full thickness dermal incised wounds

Theunissen, D.; Seymour, B; Forder, M. D.; S, Cox; Rode, H.

doi:10.1016/j.burns.2015.09.014

Cited by 15 publications

(14 citation statements)

References 19 publications

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“…Moreover, information regarding the progression through every phase of wound healing can also be obtained via gross morphology observation [51]. For instance, the inflammatory phase can be characterized by the signs of erythema, heat, oedema, pain, and functional disturbance experienced by the animal.…”

Section: Gross Appearancesmentioning

confidence: 99%

Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review

Sallehuddin

Nordin

Idrus

2020

IJERPH

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Nigella sativa (NS) has been reported to have a therapeutic effect towards skin wound healing via its anti-inflammatory, tissue growth stimulation, and antioxidative properties. This review examines all the available studies on the association of Nigella sativa (NS) and skin wound healing. The search was performed in Medline via EBSCOhost and Scopus databases to retrieve the related papers released between 1970 and March 2020. The principal inclusion criteria were original article issued in English that stated wound healing criteria of in vivo skin model with topically applied NS. The search discovered 10 related articles that fulfilled the required inclusion criteria. Studies included comprise different types of wounds, namely excisional, burn, and diabetic wounds. Seven studies unravelled positive results associated with NS on skin wound healing. Thymoquinone has anti-inflammatory, antioxidant, and antibacterial properties, which mainly contributed to wound healing process.

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Section: Gross Appearancesmentioning

confidence: 99%

Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review

Sallehuddin

Nordin

Idrus

2020

IJERPH

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“…Comparing the first 2 days of each group, we found that the CSPAH containing EGF can heal the wound more quickly, which indicates that EGF promotes wound healing. 33 Hydrogel contains a lot of water, which can serve as the ECM. Thus, the cells can enter the water network structure, increasing migration of epithelial cells which can further promote wound healing.…”

Section: Resultsmentioning

confidence: 99%

Chitosan-based hydrogels prepared by UV polymerization for wound dressing

Yao

Lin

Sue

et al. 2019

Polymers and Polymer Composites

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Chitosan-based hydrogels were prepared by grafting with poly(acrylic acid) (PAA) and poly(hydroxyethyl methacrylate) (pHEMA) through ultraviolet polymerization to further improve its hydrophilic nature and enhance its mechanical properties. The epidermal growth factor (EGF) was incorporated inside the hydrogels to stimulate the wound healing. The physical characterization of chitosan-PAA-pHEMA hydrogel indicates that it is highly hydrophilic with adequate properties for wound dressing purpose. The biological characterization shows that chitosan-based hydrogel retains its thrombogenic and antibacterial properties. The in vivo wound healing experiment demonstrates that the hydrogel-incorporated EGF has better wound healing rate than other dressings.

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“…In the current study, we prepared the IF-PG and tested in a punch wound model in rats. Mupirocin was used as a bio-equivalent formulation, which was previously used in several animal models of wound healing (Farahpouret al, 2017, Mahboubiet al, 2016, Nayaket al, 2017, Theunissenet al, 2016). Controls were also maintained including punch wound untreated and treated with a gel-base.…”

Section: Discussionmentioning

confidence: 99%

Invalid freeze-dried platelet gel promotes wound healing

Chuncharunee

Waikakul

Wongkajornsilp

et al. 2019

Saudi Pharmaceutical Journal

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Wound healing is the curative process of tissue injury, composed of three phases: the inflammatory phase, proliferative phase, followed by the maturation cum remodeling phase. Various treatment options were previously depicted for wound healing, however a treatment that accelerates these phases would be highly valuable. Platelet aggregation at the bleeding vessels and release of various growth factors are the most promising factors that stimulates the wound healing progress. In the present study, we hypothesized that the freeze-dried platelet which were normally discarded from the blood banks due to invalidity, might be promising to accelerate the phases of wound healing. The invalid freeze-dried platelets were prepared to a gel form called invalid freeze-dried platelet gel (IF-PG), which was tested for its efficacy in a cutaneous punch wound model in rats. Mupirocin antibiotic gel was used as a bio-equivalent formulation. The wound healing phases and changes in the wound sites were determined by assessing the wound sizes, histopathological analysis, immunohistochemical staining. The re-epithelialization at the wound sites at different time intervals till the wound closure was also determined. Our results suggest the beneficial effects of IF-PG; in reducing the wound area and accelerating wound closure in the cutaneous punch wound in rats. Histopathology and immunostaining results support the improvements in the wound when treated with IF-PG, which were similar to that of mupirocin antibiotic gel. Our preliminary findings also warrant the competency of IF-PG in modulating the different phases of wound healing process. In conclusion, IF-PG might be a resourceful alternative for the wound care management, however further studies are required to validate its impact on various growth factors before proceeding to clinical studies.

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Measurements in wound healing with observations on the effects of topical agents on full thickness dermal incised wounds

Cited by 15 publications

References 19 publications

Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review

Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review

Chitosan-based hydrogels prepared by UV polymerization for wound dressing

Invalid freeze-dried platelet gel promotes wound healing

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