Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review

Sallehuddin, Nusaibah; Nordin, Abid; Idrus, Ruszymah Bt Hj

doi:10.3390/ijerph17114160

Cited by 52 publications

(50 citation statements)

References 69 publications

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“…TQ was correspondingly able to expand MSC immunomodulatory potential, as well as self-renewal ability and “stemness” by influencing the associated gene expression in vivo and in vitro [ 104 , 105 ]. Other experiments observed the significantly increased therapeutic potential and healing ability of MSCs after administration of NS extract to the damaged sites [ 106 , 108 ]. Such results may indicate a great regenerative accelerating potential of NS and TQ mediators if administered adjunctively to periodontal therapy.…”

Section: Modes Of Action Of Nigella Sativa and mentioning

confidence: 99%

Nigella sativa and Thymoquinone: A Natural Blessing for Periodontal Therapy

2020

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Thymoquinone (TQ), the chief active constituent of Nigella sativa (NS), shows very valuable biomedical properties such as antioxidant, antimicrobial, anticancer, anti-inflammatory, antihypertensive, hypoglycemic, antiparasitic and anti-asthmatic effects. Several studies have examined the pharmacological actions of TQ in the treatment of oral diseases but its potential role in periodontal therapy and regeneration is not yet fully defined. The present investigation has been designed to review the scientific studies about the effects of TQ as an adjunct to periodontal treatment to promote healing and periodontal regeneration. Along with clinical experiments, in vitro studies exhibit the beneficial effects of TQ during periodontal therapy. Nevertheless, additional comprehensive clinical and preclinical studies at cellular and molecular levels are essential to examine the particular action mechanisms of Nigella sativa and its elements, particularly TQ, during periodontal treatment or regeneration.

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Section: Modes Of Action Of Nigella Sativa and mentioning

confidence: 99%

Nigella sativa and Thymoquinone: A Natural Blessing for Periodontal Therapy

2020

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“…Only one paper had results on the antimicrobial analysis of the black seeds. Information extracted from Sallehuddin et al (2020) and Rajabian & Hosseinzadeh (2020) will be used in the discussion because these two papers only described the research that other researches had done.…”

Section: / / Resultsmentioning

confidence: 99%

“…In the paper written by Sallehuddin et al (2020), the author had mentioned the black seeds contained TQ that had many medicinal benefits such as antioxidant, antiinflammatory, antibacterial, and providing protection for the renal as well as for the nerve function. The black seeds also had several good outcomes when they are used as the agent for wound healing.…”

Section: Discussionmentioning

confidence: 99%

“…Besides that, some of the papers reported that the black seeds lower down the number of white blood cells and reduce the extent of tissue damage and a bacterial infection. Sallehuddin et al (2020) also included many relevant papers that depicted the action of black seeds in wound treatments. One of the papers included in the study written by Selçuk et al (2013) used TQ extracted from the black seeds to treat burn wounds.…”

Section: Discussionmentioning

confidence: 99%

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review of black seed extract as an agent in the wound healing process

Zaid

Hanafi

Haris

2021

JoP

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Introduction: Nigella Sativa or Black Cumin is an annual flowering plant that can be used for wound treatment. In the treatment for wound healing, this plant contains many beneficial components that can help with the treatment but this plant utilisation in the medical field is still limited. This review will provide an overview of the advantages when this plant is used in the wound healing treatment. Method: The review was based on the ROSES protocol, and the databases used were ScienceDirect, PubMed, and Google Scholar. After the search, only 11 papers had been chosen to be included in the results and they were divided into four main themes that were used for the analysis of the results. Results: The themes were gross analysis, microscopic analysis, biochemical analysis and antimicrobial analysis. Conclusion: In conclusion, the black seed extract contains several valuable properties, such as antimicrobial and antioxidant properties, which help improve the wound healing process. Further study needs to be done to discover more potential of Nigella Sativa in treating the wound.

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“…The usage of natural products increases when prescribed medicines were ineffective in the treatment of chronic diseases. The identification of potential drugs to effectively inhibit the progression of AD is crucial, thus many natural plants including Nigella sativa (NS) are also being proposed for its phytopharmaceuticals in the treatment of AD (7)(8)(9) .…”

Section: Introductionmentioning

confidence: 99%

In Silico Prediction of Potential Compounds of Nigella sativa as Aromatase Agonists and Ability to Cross the Blood-Brain Barrier for treatment of Alzheimer’s Disease

Andriana¹,

Nurdiana²,

Barlıanto³

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Background: Alzheimer's disease (AD), is a chronic neurodegenerative disease which condition is characterized by a decline in memory, thinking skills, and the ability to perform basic activities of daily living. Study showed that postmenopausal women with AD had a lower aromatase activity (p450 aromatase) in the brain compared to menopausal women without AD. To improve cognitive function in AD patients, Nigella sativa (NS) was found to have a protective effect on memory, and cognitive function. This study therefore, aimed to investigate in silico prediction of potential compounds of Nigella sativa as aromatase agonists and ability to cross the Blood-Brain Barrier (BBB) for treatment of Alzheimer's Disease. Methods: The data sets used in this study were collected from databases KnapSack Kanaya, PubChem, and PASS server Way2Drug. HitPick and Autodock Vina was performed. Additionally, the systematic analysis involved ADMET, LMMD, and SWISS ADME. Results and Discussions: In silico test results revealed the most promising constituents in 36 active NS compounds that may have potential to reduce the severity of the AD, owing to its anti-inflammatory, cytochrome p450 stimulants, free radical scavengers, antioxidants, and immunomodulators. The ability of NS to cross the BBB was proven by admetSAR LMMD with an analysis average value of 0.91 (from the highest value of 1). Further, NS can trigger cytochrome P450 aromatase activity via Quercetin 3-(6'' ''-feruloylglucosyl)-(1->2)-galactosyl-(1->2)-glucoside which has a better binding affinity value than its control (androstenedione). NS through oleic acid compounds may bind to peroxisome proliferator-activated receptor gamma (PPRAG), similar to Rosiglitazone which may affect transcription and activation regulation of PPARG. Conclusion: To be concluded, Nigella sativa could be used as a potential medicinal plant for the treatment of Alzheimer's disease.

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Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review

Cited by 52 publications

References 69 publications

Nigella sativa and Thymoquinone: A Natural Blessing for Periodontal Therapy

Nigella sativa and Thymoquinone: A Natural Blessing for Periodontal Therapy

review of black seed extract as an agent in the wound healing process

In Silico Prediction of Potential Compounds of Nigella sativa as Aromatase Agonists and Ability to Cross the Blood-Brain Barrier for treatment of Alzheimer’s Disease

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