Characterization and miRNA-mediated posttranscriptional regulation of vitelline membrane outer layer protein I in the adult chicken oviduct

Lee, Sang In; Ji, Mi-Ran; Jang, Yejin; Jeon, Mi-Hyang; Kim, Jeom Sun; Park, Jin-Ki; Jeon, Ik Soo; Byun, Sung June

doi:10.1007/s11626-014-9826-2

Cited by 8 publications

(2 citation statements)

References 27 publications

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“…It has been found in a previous study that the expression of VEGF is altered in the occurrence and development of AD, which may be associated with the disease process ( 4 ). Recently, the role of microRNA (miRNA) in post-transcriptional gene regulation has been uncovered ( 5 ). VEGF has been observed to be one of the targets of miRNA-210 ( 6 ), and a previous study has shown that the upregulation of miRNA-210 can increase the expression of VEGF in kidney tissue ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Quantification of microRNA-210 in the cerebrospinal fluid and serum: Implications for Alzheimer’s disease

Zhu

Sun

et al. 2015

Experimental and Therapeutic Medicine

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The aim of the present study was to investigate the potential clinical application of the genetic marker microRNA (miRNA)-210 in the cerebrospinal fluid (CSF) and serum of patients with Alzheimer’s disease (AD). The enrolled patients were divided into the mild cognitive impairment (MCI) and AD groups. Healthy individuals were used as the controls. The mRNA and protein expression of vascular endothelial growth factor (VEGF) in the CSF and serum samples was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis, respectively. The expression of miRNA-210 in the CSF and serum was detected by RT-qPCR. The results revealed that the mRNA and protein expression levels of VEGF in the CSF and serum were decreased in the MCI and AD groups compared with those in the control group. The greater the severity of the dementia, the lower the mRNA and protein expression of VEGF. Similar to the trend observed for VEGF, the miRNA-210 expression in the CSF and serum decreased as the severity of the AD increased. miRNA-210 is thus not only indicative of AD pathogenesis, but may also provide novel insights into the prevention and treatment of the disease.

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Section: Introductionmentioning

confidence: 99%

Quantification of microRNA-210 in the cerebrospinal fluid and serum: Implications for Alzheimer’s disease

Zhu

Sun

et al. 2015

Experimental and Therapeutic Medicine

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“…As Klinge (2009, 2012) reviewed the role of the estrogen-regulated miRNA expression, E2 regulates selective miRNA expressions in female mammalian reproductive tissues. A recent study reported the E2-mediated regulation of miRNA in the chicken oviduct (In Lee et al, 2015). Therefore, the miRNA of the miRCN created in this study can be suggested to be the estrogen-mediated regulation factors in the induction of molting.…”

Section: Resultsmentioning

confidence: 99%

Rapid Communication: MicroRNA co-expression network reveals apoptosis in the reproductive tract during molting in laying hens1,2

Kim

Lim

Bazer

et al. 2017

Journal of Animal Science

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The aim of this study was to determine the regulatory mechanisms of molting and recrudescence via studying the micro-RNA (miRNA) expression in the oviduct of laying hens. We performed a cDNA microarray analysis in the magnum tissue from the oviduct to identify the whole miRNA profiles through the molting and recrudescence periods. A total of 35 laying hens (47-wk-old) were divided into 7 groups (0 d: a control group; 6 and 12 d: 2 molting-period groups fed on a high-zinc diet; and 20, 25, 30, and 35 d: 4 recrudescence-period groups fed on a normal diet after a 12-d period on a high-zinc diet). An miRNA co-expression network (miRCN) was generated using the differentially expressed miRNA (DEM) according to the entire data integration. The significantly co-expressed miRNA ( = 111) were highly differentially expressed from 12 to 20 d, which was a transition period between molting and recrudescence, while their expression patterns were contrary to the estrogen changes. The targets of highly connected miRNA ( = 12) indicated the significant biological pathways and gene ontology (GO) terms, such as MAPK and Wnt signaling and magnesium-ion binding, which are associated with apoptotic activities. These results suggest that the miRNA of the miRCN might play a role in the apoptotic progression of the reproductive tract during molting.

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Female Reproductive System and Immunology

Yoshimura

Barua

2017

Advances in Experimental Medicine and Biology

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Health of the reproductive organs is essential for formation and production of high quality and hygienic eggs. It is of importance to review the structures and functions of female reproductive system for better understanding of the mechanism by which the eggs are formed. The unique functions of ovarian cells for follicular growth and differentiation as well as steroidogenesis and oocyte maturation are regulated by gonadotropins and gonadal steroids. The oviduct is responsible for egg formation, while the unique function to store sperms for a prolonged period takes place in the specific tissue of this organ. The unique innate and adaptive immuno-defense systems that play essential role to prevent infection are developed in the ovary and oviduct. Toll-like receptors (TLRs) that recognize the molecular pattern of microbes and initiate the immunoresponse are expressed in those organs. Avian β-defensins (AvBDs), a member of antimicrobial peptides, are synthesized by the ovarian and oviductal cells. Challenge of those cells by TLR ligands upregulates the expression of proinflammatory cytokines, which in turn stimulate the expression of AvBDs. The adaptive immune system in the ovary and oviduct is also unique, since the migration of lymphocytes is enhanced by estrogens. In contrast to the development of immuno-defense system, spontaneous ovarian cancer and uterine fibroids appear more frequently in chickens than in mammals, and thus chickens could be used as a model for studying these diseases. Thus the avian reproductive organs have unique functions not only for egg formation but also for the immuno-defense system, which is essential for prevention of infection and production of hygienic eggs.

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Characterization and miRNA-mediated posttranscriptional regulation of vitelline membrane outer layer protein I in the adult chicken oviduct

Cited by 8 publications

References 27 publications

Quantification of microRNA-210 in the cerebrospinal fluid and serum: Implications for Alzheimer’s disease

Quantification of microRNA-210 in the cerebrospinal fluid and serum: Implications for Alzheimer’s disease

Rapid Communication: MicroRNA co-expression network reveals apoptosis in the reproductive tract during molting in laying hens1,2

Female Reproductive System and Immunology

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