The aim of the present study was to investigate the potential clinical application of the genetic marker microRNA (miRNA)-210 in the cerebrospinal fluid (CSF) and serum of patients with Alzheimer’s disease (AD). The enrolled patients were divided into the mild cognitive impairment (MCI) and AD groups. Healthy individuals were used as the controls. The mRNA and protein expression of vascular endothelial growth factor (VEGF) in the CSF and serum samples was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis, respectively. The expression of miRNA-210 in the CSF and serum was detected by RT-qPCR. The results revealed that the mRNA and protein expression levels of VEGF in the CSF and serum were decreased in the MCI and AD groups compared with those in the control group. The greater the severity of the dementia, the lower the mRNA and protein expression of VEGF. Similar to the trend observed for VEGF, the miRNA-210 expression in the CSF and serum decreased as the severity of the AD increased. miRNA-210 is thus not only indicative of AD pathogenesis, but may also provide novel insights into the prevention and treatment of the disease.
Bi2223 multifilamentary tapes with enhanced transverse resistivity by introducing Ca2CuO3 and SrZrO3 as interfilamentary barriers were prepared and their AC loss properties were examined under AC external magnetic field. To improve the deformation properties of these oxide powders, 20-30wt% Bi2212 powders were mixed with them. The mixed oxide powders were introduced among the twisted Bi2223 filaments by using dip-coating method. AC loss properties under AC parallel or perpendicular field were measured and compared with the results for the tape without barriers. The loss measurements were carried out by changing both the amplitude and the frequency of external field. Based on the experimental results, the effect of barrier introduction on the loss reductions was discussed.
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