245. Griseofulvin analogues. Part V. Infrared absorption

Page, J. E.; Staniporth, Susan E.

doi:10.1039/jr9620001292

Cited by 15 publications

(16 citation statements)

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“…Following successful clinical use of griseofulvin, a more extensive series of griseofulvin analogues, prepared for an investigation of relations between structure and biological activity, was described (Arkley, Attenburrow, Gregory & Walker, 1963;Gregory, Holton, Robinson & Walker, 1962 ;Stephenson, Walker, Warburton & Webb, 1962;Page & Staniforth, 1962;Goodall, Gregory & Walker, 1963;Page & Staniforth, 1963). We now report some biological results with these compounds against six dermatophytic and eight plant pathogenic fungi in vitro together with observations on antifungal action following upon foliage application of selected 4-2 R. CROSSE, R. MCWILLIAM AND A. RHODES analogues in vivo against Botrytis cinerea on tomatoes, Erysiphc!…”

Section: Introductionmentioning

confidence: 98%

Some Relations between Chemical Structure and Antifungal Effects of Griseofulvin Analogues

Crosse¹,

McWilliam²,

Rhodes³

1964

Journal of General Microbiology

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SUMMARYInhibitory effects of more than 300 analogues of griseofulvin against six dermatophytic fungi and eight plant pathogenic fungi were determined in an investigation of relations between chemical structure and biological activity. The influence of chemical structure on physical properties of the analogues appeared dominant, but optimum requirements for in vitro performance were somewhat different from those required in vivo for effective control of plant pathogenic or dermatophytic fungi.

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Section: Introductionmentioning

confidence: 98%

Some Relations between Chemical Structure and Antifungal Effects of Griseofulvin Analogues

Crosse¹,

McWilliam²,

Rhodes³

1964

Journal of General Microbiology

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“…Furthermore, Figure 1c shows clear GF features, including (C=O) absorption bands at 1710 and 1664 cm −1 and the (C=C) absorption band at 1625 cm −1 for spectra obtained in the particle regions. 35 It also shows a complete absence of these features for spectra obtained outside the particle regions (in the HPMC matrix).…”

Section: Resultsmentioning

confidence: 94%

Atomic Force Microscope Infrared Spectroscopy of Griseofulvin Nanocrystals

et al. 2013

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The goal of this work was to evaluate the ability of photothermal induced resonance (PTIR) to measure the local infrared absorption spectra of crystalline organic drug nanoparticles embedded within solid matrices. Herein, the first reports of the chemical characterization of sub-100 nm organic crystals are described; infrared spectra of 90 nm griseofulvin particles were obtained, confirming the chemical resolution of PTIR beyond the diffraction limit. Additionally, particle size distributions via dynamic light scattering and PTIR image analysis were found to be similar, suggesting that the PTIR measurements are not significantly affected by inhomogeneous infrared absorptivity of this system. Thus as medical applications increasingly emphasize localized drug delivery via micro/nano-engineered structures, PTIR can be used to unambiguously chemically characterize drug formulations at these length scales.

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“…The spectra were compared with those obtained with chloroform solutions of authentic griseofulvin and spectral assignments were made according to the interpretation of Page and Staniforth (4).…”

Section: Resultsmentioning

confidence: 99%