SUMMARYInhibitory effects of more than 300 analogues of griseofulvin against six dermatophytic fungi and eight plant pathogenic fungi were determined in an investigation of relations between chemical structure and biological activity. The influence of chemical structure on physical properties of the analogues appeared dominant, but optimum requirements for in vitro performance were somewhat different from those required in vivo for effective control of plant pathogenic or dermatophytic fungi.

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The antifungal protection afforded by streptomycin‐copper chelate in vivo in greenhouse tests against Phytophthora infestans on tomato was found to be of the order of six times greater than that of streptomycin sulphate. The copper chelate also showed much greater resistance to simulated rainfall. Similar tests showed that streptomycin‐copper chelate (in terms of streptomycin content) was from 2 1/2 to 5 times more effective as an antifungal prophylactic spray than zinc ethylene‐bis(dithiocarbamate) (zineb), and some fifty times more active than copper oxychloride formulated as a commercial 50% wettable powder. These three materials showed roughly similar resistance to weathering by ‘rainfall’ and it was assumed therefore that 250 i.u./ml. streptomycin as streptomycin‐copper chelate might be expected to give the same degree of protection against Phytophthora infestans in the field as would the usual field rates of usage of zineb and copper oxychloride.

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