SUMMARYInhibitory effects of more than 300 analogues of griseofulvin against six dermatophytic fungi and eight plant pathogenic fungi were determined in an investigation of relations between chemical structure and biological activity. The influence of chemical structure on physical properties of the analogues appeared dominant, but optimum requirements for in vitro performance were somewhat different from those required in vivo for effective control of plant pathogenic or dermatophytic fungi.
Lone parents and their children are the biggest group at risk of living in poverty in Ireland, and activation is regarded as the solution to this problem by policymakers. While workfare requirements are now placed on lone parents whose youngest child is aged 14 or over, we question the capacity of the current activation policy to deliver an adequate income for these families. Drawing on evidence from other countries and the current Irish context, we argue that the absence of tailored support for lone parents, low levels of educational attainment, difficulties with childcare, the efficacy of financial supports to provide income adequacy and the failure to take into consideration their parenting responsibility mean that the implementation of the policy is fraught with difficulty.
Six dogs and six cats were given a single oral tableted dose containing approximately 15 mg/kg bodyweight of the semisynthetic cephalosporin antibiotic, cephalexin. Three dogs and four cats were similarly dosed using a liquid preparation of the same antibiotic. At intervals after dosing, blood samples were taken and the level of antibiotic in the serum was determined by bioassay. After fitting the results to a mathematical model the calculated peak serum level of antibiotic was found to be about 15 micrograms/ml and to occur between one and two hours after dosing. Results agree with the performance of the antibiotic in human medicine.
The issue of post separation abuse is a significant problem for women. This qualitative research examines Irish women's experiences of domestic abuse in cases of separation and divorce. Findings show that methods of abuse change upon separation and perpetrators can utilise institutions of the state to continue their abusive behaviour in a new forum and can continue long after marital dissolution is finalised. Such behaviour is legitimised by the state's non-action and enabled through women's previous experiences of institutional processes associated with separation and divorce which resulted in feelings fear and distress.
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